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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pumilio homolog 2

Top mentioned proteins: Pumilio, CAN, V1a, CPEB, miR
Papers on PUM2
Spermatogonial stem cells specific marker identification in channel catfish, Ictalurus punctatus and blue catfish, I. furcatus.
Dunham et al., Auburn, United States. In Fish Physiol Biochem, Dec 2015
Oct4, Id4, Gfrα2, Pum2 and Prdm14 genes showed different expression patterns in the testicular germ cells of channel and blue catfish.
Reduced Pumilio-2 expression in patients with temporal lobe epilepsy and in the lithium-pilocarpine induced epilepsy rat model.
Chen et al., Chongqing, China. In Epilepsy Behav, Sep 2015
OBJECTIVE: Drosophila Pumilio (Pum), a homolog of mammalian Pum2, plays an important role in translational regulation in the central nervous system (CNS), particularly for dendrite outgrowth and neuronal excitability.
Loss of preimplantation embryo resulting from a Pum1 gene trap mutation.
Xu et al., Nanjing, China. In Biochem Biophys Res Commun, Jul 2015
Two Pumilio genes, Pum1 and Pum2, have been identified in mammals and are found to be involved in sperm development, neuron development as well as human diseases such as neurodegeneration.
miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer.
Verde et al., Napoli, Italy. In Oncogene, Jun 2015
The miR-340-mediated inhibition of both Pumilio family RNA-binding proteins (PUM1 and PUM2), required for the miR-221/222 interaction with the p27 3'-UTR, antagonizes the miRNA-dependent downregulation of p27.
Regulation of membrane excitability: a convergence on voltage-gated sodium conductance.
Baines et al., Manchester, United Kingdom. In Mol Neurobiol, Feb 2015
Pum2-deficient mice exhibit spontaneous EEG abnormalities.
mRNA fragments in in vitro culture media are associated with bovine preimplantation embryonic development.
Khatib et al., Madison, United States. In Front Genet, 2014
To better understand the mechanisms of mRNA secretion into the media, the expression of a predicted RNA binding protein of POSTN, PUM2, was knocked down using an antisense oligonucleotide gapmer.
MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression.
Schratt et al., Marburg an der Lahn, Germany. In Embo J, 2014
Downregulation of the miR-134 target Pumilio-2 in response to chronic activity, which selectively occurs in the synapto-dendritic compartment, is required for miR-134-mediated homeostatic synaptic depression.
A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.
Fujita et al., Kyoto, Japan. In Plos Pathog, 2014
By expression cloning, we identified Pumilio proteins, PUM1 and PUM2, as candidate positive regulators of RIG-I signaling.
The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.
Goldstrohm et al., Ann Arbor, United States. In Rna, 2014
Furthermore, we show that repression by the human PUM2 RBD requires the pAbp ortholog, PABPC1.
Specificity factors in cytoplasmic polyadenylation.
de Moor et al., Denver, United States. In Wiley Interdiscip Rev Rna, 2013
In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1).
An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.
Miller et al., Toronto, Canada. In Cell Stem Cell, 2012
We show that the RNA-binding protein Staufen2 (Stau2) is apically localized in radial glial precursors of the embryonic cortex, where it forms a complex with other RNA granule proteins including Pumilio2 (Pum2) and DDX1, and the mRNAs for β-actin and mammalian prospero, prox1.
Pumilio facilitates miRNA regulation of the E2F3 oncogene.
Dyson et al., United States. In Genes Dev, 2012
human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)
A conserved PUF-Ago-eEF1A complex attenuates translation elongation.
Kimble et al., Madison, United States. In Nat Struct Mol Biol, 2012
Mammalian PUM2-Ago-eEF1A inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro.
Translational regulation of acetylcholinesterase by the RNA-binding protein Pumilio-2 at the neuromuscular synapse.
Rotundo et al., Miami, United States. In J Biol Chem, 2011
PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse.
NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.
Jaruzelska et al., Poznań, Poland. In Histochem Cell Biol, 2011
NANOS1-PUMILIO2 complex, together with GEMIN3 and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
Pumilio-2 function in the mouse nervous system.
Pera et al., Stanford, United States. In Plos One, 2010
Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges
Pumilio turns on microRNA function.
Gregory et al., In Nat Cell Biol, 2010
Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA.
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Tuschl et al., New York City, United States. In Cell, 2010
We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C.
Candidate mRNAs interacting with fertility protein PUMILIO2 in the human germ line.
Jaruzelska et al., Poznań, Poland. In Reprod Biol, 2005
PUMILIO mediated translational regulation may be universally used in developmental processes of the human body.
The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?
Jurecic et al., Miami, United States. In Iubmb Life, 2003
We also suggest that a conserved mechanism of PUF function extends to the newly described mammalian members of the PUF family (human PUM1 and PUM2, and mouse Pum1 and Pum2), that show extensive homology to Drosophila Pum, and could have an important role in cell development, fate specification and differentiation.
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