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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Pentraxin 3, long

PTX3, pentraxin 3, Pitx3
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: C-reactive protein, HAD, CAN, AGE, Interleukin-6
Papers on PTX3
PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition.
Review
New
Mantovani et al., Milano, Italy. In Curr Opin Immunol, Feb 2016
PTX3 is a fluid patter recognition molecule (PRM) with antibody-like properties.
Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.
New
Wizenmann et al., München, Germany. In Development, Feb 2016
We detected striking differences in the expression patterns of the chick orthologs of the mouse mdDA marker genes Pitx3 and Aldh1a1, which suggests important differences between the species in the generation/generating of these cells.
Niche Regulation of Limbal Epithelial Stem Cells: Relationship between Inflammation and Regeneration.
Review
New
Chen et al., Miami, United States. In Ocul Surf, Feb 2016
HC-HA complex is covalently formed by hyaluronan (HA) and heavy chain 1 (HC1) of inter-α-trypsin inhibitor by the catalytic action of tumor necrosis factor-stimulated gene-6 (TSG-6) and are tightly associated with pentraxin 3 (PTX3) to form HC-HA/PTX3.
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.
Review
New
Chavakis et al., Philadelphia, United States. In Curr Opin Hematol, Jan 2016
Furthermore, several endogenous inhibitory mechanisms of leukocyte recruitment have been identified, including the secreted molecules Del-1, PTX3, and GDF-15, which block distinct steps of the leukocyte adhesion cascade, as well as novel regulatory signaling pathways, involving the protein kinase AKT1 and IFN-λ2/IL-28A.
Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling.
New
D'Amico et al., Monza, Italy. In J Invest Dermatol, Jan 2016
Because a nonredundant role of pentraxin 3 (PTX3) in tissue repair and remodeling has been recently described, here we sought to determine whether MSC-derived PTX3 might play a role in wound healing.
Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis.
New
Ferreira et al., Belo Horizonte, Brazil. In Plos One, Dec 2015
Pre-treatment with the conventional biological Etanercept, an inhibitor of TNF action, ameliorated the nociception and the acute joint inflammation dominated by neutrophils, and markedly improved many of the altered systemic metabolites (glucose and lipids), adipocytokines and PTX3.
Brain diseases and tumorigenesis: The good and bad cops of pentraxin3.
Review
New
Vecchione et al., Pisa, Italy. In Int J Biochem Cell Biol, Dec 2015
The prototype of long pentraxins, Pentraxin 3 (PTX3), is an evolutionarily conserved multifunctional, pattern-recognition protein constituted by a cyclic multimeric structure.
Laboratory markers predicting severity of acute pancreatitis.
Review
New
Nebiker et al., Basel, Switzerland. In Crit Rev Clin Lab Sci, Dec 2015
Most other markers, including acute phase proteins (LBP, SAA, PTX3), cytokines (Il-8, TNF-a, MIF), activation peptides of pancreatic proteases (TAP, CAPAP, PLAP), antiproteases (AAT, a2M), adhesion molecules (ICAM-1, selectins, E-cadherin) and leukocyte-derived enzymes (PA2, PMN-E) have shown some promising results but have not been routinely implemented.
Beyond Cholesterol - New Cardiovascular Biomarkers.
New
Mangge, In Nestle Nutr Inst Workshop Ser, Dec 2015
New biomarkers in these mechanisms include pentraxin 3, calprotectins S100A8/S100A9, myeloperoxidase, adiponectin, interleukins, and chemokines.
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
New
Impact
Presta et al., Brescia, Italy. In Cancer Cell, Sep 2015
The soluble pattern recognition receptor long-pentraxin 3 (PTX3) acts as a multi-FGF antagonist.
[Clinical study of Pentraxin 3 in diagnosing the severity and cardiovascular function of the children with sepsis].
New
Zhang et al., In Zhonghua Er Ke Za Zhi, Aug 2015
OBJECTIVE: To study the value of Pentraxin 3 (PTX3) in diagnosing the severity and cardiovascular function of the critically ill children.
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
New
Impact
Mantovani et al., Milano, Italy. In Cell, Mar 2015
PTX3 is an essential component of the humoral arm of innate immunity, playing a nonredundant role in resistance against selected microbes and in the regulation of inflammation.
The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Impact
Mantovani et al., Milano, Italy. In Immunity, 2014
We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs.
Peeing pentraxins.
Impact
Abraham et al., Durham, United States. In Immunity, 2014
In this issue of Immunity, Jaillon et al. (2014) describe a role for pentraxin 3 molecules in complementing the host's cellular innate immune responses to uropathogens.
Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.
Impact
Carvalho et al., Aş Şanamayn, Syria. In N Engl J Med, 2014
BACKGROUND: The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity.
Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.
GeneRIF
Liu et al., Toronto, Canada. In Lab Invest, 2012
PTX3 deficiency enhanced early infiltration of neutrophils and macrophages in the lung. PTX3 bound to MHV-1 and MHV-3 and reduced MHV-1 infectivity in vitro
Plasma pentraxin-3 levels are associated with coronary plaque vulnerability and are decreased by statin.
GeneRIF
Saku et al., Fukuoka, Japan. In Coron Artery Dis, 2012
The plasma level of PTX3 may be a useful biomarker for predicting the tissue characteristics of coronary plaque using integrated backscatter intravascular ultrasound. Statin therapy may have a beneficial effect with regard to the reduction of PTX3 levels.
Serum Fetuin-A and Pentraxin3 in hemodialysis and renal transplant patients.
GeneRIF
Meimand et al., Tabrīz, Iran. In Clin Biochem, 2012
Data show in the renal transplant (RT) recipients serum Pentraxin3 (PTX3) was significantly higher than the hemodialysis (HD) patients.
Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
GeneRIF
Gounni et al., Winnipeg, Canada. In Plos One, 2011
PTX3 expression is increased in asthmatic airways. HASMC can both produce and respond to PTX3. PTX3 is a potent inhibitor of HASMC migration induced by FGF-2 and can upregulate CCL11/eotaxin-1 release.
Pentraxin 3(PTX 3): an endogenous modulator of the inflammatory response.
Review
GeneRIF
Krejsek et al., Praha, Czech Republic. In Mediators Inflamm, 2011
Pentraxin 3(PTX 3) is an endogenous modulator of the inflammatory response [review]
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