Molecular Mechanisms Underlying Pituitary Pathogenesis.
Buenos Aires, Argentina. In Biochem Genet, Jan 2016
Pituitary tumor transforming gene (PTTG) is an oncogene involved in early stages of pituitary tumor development, and also triggers a senescence response by activating DNA-damage signaling pathway.
Gene expression profiling of lung adenocarcinoma in Xuanwei, China.
Kunming, China. In Eur J Cancer Prev, Jan 2016
The tendency of changes in the expression of 12 selected DEGs (five downregulated genes, PIK3R1, RARB, HGF, MAPK11, and SESN1, and seven upregulated genes, PAK1, E2F1, CCNE1, EGF, CDC25A, PTTG1, and UHRF1) in RTq-PCR was consistent with the expression profiling data.
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese.
Beijing, China. In Sci Rep, 2014
Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4.
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Oklahoma City, United States. In Nat Genet, 2013
We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
The genetics of psoriasis and psoriatic arthritis.
Toronto, Canada. In Clin Rev Allergy Immunol, 2013
The susceptibility genes identified include HLA-C, IL13, IL4, TNFAIP3, IL23A, IL23R, IL28RA, REL, IFIH1, ERAP, TRAF3IP2, NFKBIA, TYK2, ZNF313, NOS2, FBXL19 and NFKBIA in subjects of European ethnicity and HLA-C, IL12B, LCE3D, ERAP1, TNIP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A in subjects of Chinese ethnicity.
The pituitary tumor transforming gene in thyroid cancer.
Birmingham, United Kingdom. In J Endocrinol Invest, 2012
The pituitary tumor transforming gene (PTTG) is a multifunctional proto-oncogene that is over-expressed in various tumors including thyroid carcinomas, where it is a prognostic indicator of tumor recurrence.
Pituitary tumor-transforming gene: physiology and implications for tumorigenesis.
Los Angeles, United States. In Endocr Rev, 2007
Pituitary tumor-transforming gene-1 (PTTG1) is overexpressed in a variety of endocrine-related tumors, especially pituitary, thyroid, breast, ovarian, and uterine tumors, as well as nonendocrine-related cancers involving the central nervous, pulmonary, and gastrointestinal systems.