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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

6-pyruvoyltetrahydropterin synthase

Pts, 6-pyruvoyltetrahydropterin synthase, PTPS
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, V1a
Papers on Pts
Patients with Refractory Crohn's Disease Successfully Treated with Ustekinumab.
New
Schwartz et al., Baltimore, United States. In Inflamm Bowel Dis, Feb 2016
METHODS: A retrospective chart review was performed including patients (pts) from 2 academic medical centers with complicated, refractory CD started on ustekinumab between June 2011 and June 2014.
Expression of lipid metabolism-related proteins in breast phyllodes tumors.
New
Koo et al., In Neoplasma, Feb 2016
The numbers of benign, borderline, and malignant PTs were 151, 27, and 16, respectively.
Complex Regulation of Plant Phosphate Transporters and the Gap Between Molecular Mechanisms and Practical Application: What Are Missing?
Review
New
Xu et al., Nanjing, China. In Mol Plant, Jan 2016
The regulatory genes affect plant Pi homeostasis commonly through direct or indirect regulation of the abundance of PTs at different levels.
Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast.
New
Noguchi et al., Suita, Japan. In Oncol Rep, Jan 2016
UNASSIGNED: Loss of imprinting (LOI) of insulin-like growth factor 2 (IGF2) is thought to be implicated in the pathogenesis of some tumors by upregulating IGF2 mRNA but its role in the pathogenesis of fibroadenomas (FAs) and phyllodes tumors (PTs) of the breast is yet to be studied.
The Plant Ovule Secretome: A Different View toward Pollen-Pistil Interactions.
New
Matton et al., Montréal, Canada. In J Proteome Res, Dec 2015
After navigating through the stigma and the style, pollen tubes (PTs) reach their final destination, the ovule.
Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants.
New
Zhang et al., Shanghai, China. In Mol Plant, Nov 2015
In the biosynthesis of plant terpenoids, short-chain prenyltransferases (SC-PTs), together with terpene synthases (TPSs), play critical roles in determining terpenoid diversity.
The phosphate transporters LjPT4 and MtPT4 mediate early root responses to phosphate status in non mycorrhizal roots.
New
Bonfante et al., Torino, Italy. In Plant Cell Environ, Nov 2015
UNASSIGNED: Arbuscular mycorrhizal (AM) symbiosis improves host plant phosphorous (P) status and elicits the expression of AM-inducible phosphate transporters (PTs) in arbuscule-containing cells, where they control arbuscule morphogenesis and P release.
Mechanisms of chromium hexavalent-induced apoptosis in testis rats.
New
Rhouma et al., Bizerte, Tunisia. In Toxicol Ind Health, Oct 2015
The expression of Bax and Bcl-2 proteins (Pts) was also investigated.
Ashkin-Teller model and diverse opinion phase transitions on multiplex networks.
New
Kahng et al., Seoul, South Korea. In Phys Rev E Stat Nonlin Soft Matter Phys, Aug 2015
Our study shows that, depending on the interlayer coupling strength and a network topology, unconventional PT patterns can also emerge in interaction-based phenomena: continuous, discontinuous, successive, and mixed-order PTs and a continuous PT not satisfying the scaling relation.
Species differences in regulation of renal proximal tubule transport by certain molecules.
Review
New
Horita et al., Tokyo, Japan. In World J Nephrol, Jun 2015
Renal proximal tubules (PTs) play important roles in the regulation of acid/base, plasma volume and blood pressure.
D1 and D2 Inhibitions of the Soleus H-Reflex Are Differentially Modulated during Plantarflexion Force and Position Tasks.
Kohn et al., São Paulo, Brazil. In Plos One, 2014
A significant main effect for the type of the motor task (FT vs PT) (p = 0.005, η2p = 0.603) indicated that PTs were undertaken with lower levels of Ia PSI converging onto the soleus motoneuron pool.
Regulatory roles of nitric oxide and angiotensin II on renal tubular transport.
Review
Seki et al., Tokyo, Japan. In World J Nephrol, 2014
In PTs, NO seems to be involved in the inhibitory effect of AngII.
Roles of renal proximal tubule transport in acid/base balance and blood pressure regulation.
Review
Seki et al., Tokyo, Japan. In Biomed Res Int, 2013
Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance.
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Impact
Itoh et al., Tokyo, Japan. In Nat Med, 2013
We found that Sirt1 in proximal tubules (PTs) was downregulated before albuminuria occurred in streptozotocin-induced or obese (db/db) diabetic mice.
Role of renal proximal tubule transport in thiazolidinedione-induced volume expansion.
Review
Fujita et al., Tokyo, Japan. In World J Nephrol, 2012
However, this stimulation was not observed in mouse PTs where Src/EGFR is constitutively activated.
Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.
GeneRIF
Liu et al., Taipei, Taiwan. In J Hum Genet, 2012
A total of 43 mutations were identified in the PTS gene in a screen of East Asian populations, comprising 22 previously reported mutations and 21 new discovered mutations.
Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.
GeneRIF
Ichinose et al., Yokohama, Japan. In J Biol Chem, 2011
biopterin contents in the brains of these knock-out mice were moderately decreased from postnatal day 0 (P0) and remained constant up to P21
[Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency].
GeneRIF
Wang et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2008
The mutant characterization of PTPS gene was coincident with other early studies in Chinese. The novel mutation L127F was considered as a pathogenetic mutation and associated with severe clinical phenotype.
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
GeneRIF
Kohno et al., Chiba, Japan. In Brain Dev, 2008
We suggest that the serum prolactin level may be a more sensitive marker than the CSF HVA level to guide the dose adjustment of L-Dopa/carbidopa in the management of patients with PTPS deficiency.
Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis.
GeneRIF
Genschel et al., Freising, Germany. In Plant Mol Biol, 2008
panC transgene increased the total pantothenate synthase activity in leaves by up to 500-fold but did not affect the steady-state level of pantothenate, indicating that pantothenate synthase is essential but not limiting for pantothenate production
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