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Polymerase I and transcript release factor

PTRF, Cavin, polymerase I and transcript release factor, cav-p60
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: caveolin-1, POLYMERASE, Insulin, CAN, HAD
Papers using PTRF antibodies
Connecting lipid droplet biology and the metabolic syndrome
Dugail Isabelle et al., In Journal of Lipid Research, 2008
... Antibodies used in this study were purchased from the following sources: anti-caveolin-1, anti-caveolin-2, anti-PTRF (BD Biosciences), anti-Glut4 (Cell Signaling), anti-perilipin ...
Papers on PTRF
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
Watanabe et al., Japan. In Oncotarget, Jan 2016
CRL and MDAMB453 cells were identified as PB-sensitive, while MDAMB231 cells were PB-resistant.RAB25 and ESRP1 were identified as key regulators of PB sensitivity, while ANKD1, ETS1, PTRF, IFI16 and KIAA1199 acted as PB resistance-related genes.
Molecular Determinants of the Cellular Entry of Asymmetric Peptide Dendrimers and Role of Caveolae.
Parat et al., Australia. In Plos One, Dec 2015
Caveola formation and functions require membrane proteins of the caveolin family, and cytoplasmic proteins of the cavin family.
Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL.
Yu et al., Shanghai, China. In Sci Rep, Dec 2015
Four major driver-genes (KRAS, TP53, CDKN2A/p16, and SMAD4/DPC4) that are associated with PDAC and five critical molecules (cavin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened by immunohistochemistry in tumor tissue microarrays.
Identification of novel therapeutic target genes in acquired lapatinib-resistant breast cancer by integrative meta-analysis.
Kim et al., Seoul, South Korea. In Tumour Biol, Oct 2015
By integrative analysis of two systemic networks, we condensed the total number of DEGs to six common genes (LGALS1, PRSS23, PTRF, FHL2, TOB1, and SOCS2).
The caveolin-cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle.
Parton et al., Brisbane, Australia. In J Cell Biol, Oct 2015
Caveola-deficient cavin-1(-/-) muscle fibers showed a striking loss of sarcolemmal organization, aberrant T-tubule structures, and increased sensitivity to membrane tension, which was rescued by muscle-specific Cavin-1 reexpression.
Cavin family proteins and the assembly of caveolae.
Collins et al., Brisbane, Australia. In J Cell Sci, May 2015
However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as essential coat components and regulators of caveola biogenesis.
Cavin Family: New Players in the Biology of Caveolae.
Parat et al., Australia. In Int Rev Cell Mol Biol, 2014
Two essential protein families are required for caveola formation: membrane caveolin proteins and cytoplasmic cavin proteins.
Emerging role of polymerase-1 and transcript release factor (PTRF/ Cavin-1) in health and disease.
Nicholson et al., Dunedin, New Zealand. In Cell Tissue Res, 2014
Polymerase-1 and release transcript factor (PTRF) was initially reported to be involved in the termination of the transcription process.
Cavin-1: caveolae-dependent signalling and cardiovascular disease.
Palmer et al., Glasgow, United Kingdom. In Biochem Soc Trans, 2014
Cavin-1 is an essential peripheral component of caveolae that stabilizes caveolin-1, the main structural/integral membrane protein of caveolae.
Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.
Nolis, Canada. In J Hum Genet, 2014
The major genetic factors in the generalized forms of the lipodystrophies, particularly Congenital generalized lipodystrophy (CGL)-Berardinelli-Seip syndrome, are the AGPAT2, BSCL2, caveolin 1 (CAV1) and polymerase-I-and-transcriptrelease factor (PTRF) genes.
[Cavins: new sights of caveolae-associated protein].
Zou et al., In Sheng Wu Gong Cheng Xue Bao, 2013
It's worth noting that Cavin-1 could cooperate with Caveolin-1 to accommodate the structural integrity and function of caveolae.
Down-regulation of the cavin family proteins in breast cancer.
Cong et al., Beijing, China. In J Cell Biochem, 2012
The cavin family protein Polymerase 1 and transcript release factor, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue.
PTRF/cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics.
Fresno Vara et al., Madrid, Spain. In Plos One, 2011
Data show that two proteins, PTRF/cavin-1 and MIF, which are differentially expressed between normal lung and non-small cell lung cancer.
A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients.
Clarke et al., Sydney, Australia. In Neuromuscul Disord, 2011
This study identified no pathogenic mutations in BAG3, MATR3, PTRF or TCAP in Australian muscular dystrophy.
Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence.
Galbiati et al., Pittsburgh, United States. In J Biol Chem, 2011
PTRF/cavin-1 is a novel regulator of oxidative stress-induced premature senescence by acting as a link between free radicals and activation of the p53/p21(Waf1/Cip1) pathway.
Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1.
Cong et al., Beijing, China. In Cell Res, 2011
PTRF expression is increased in senescent human fibroblasts.
Cavin fever: regulating caveolae.
Nabi, In Nat Cell Biol, 2009
SDPR is a new regulator of caveolae biogenesis.
SDPR induces membrane curvature and functions in the formation of caveolae.
Nichols et al., Cambridge, United Kingdom. In Nat Cell Biol, 2009
The mechanism by which caveolae are generated is not fully understood, but both caveolin proteins and PTRF (polymerase I and transcript release factor, also known as cavin) are important.
Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.
Pilch et al., Boston, United States. In Cell Metab, 2008
We show here by means of targeted gene disruption in mice that a distinct caveolae-associated protein, Cavin/PTRF, is an essential component of caveolae.
PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function.
Parton et al., Brisbane, Australia. In Cell, 2008
We conclude that PTRF-Cavin is required for caveola formation and sequestration of mobile caveolin into immobile caveolae.
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