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Protein tyrosine phosphatase, receptor type, R

PTPRR, PTP-SL, PTPBR7
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Pts, MAPK, ERK, STEP, ERK1
Papers on PTPRR
Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.
New
Haiman et al., Los Angeles, United States. In Hum Mol Genet, Feb 2016
We identified 395 220 coding variants down to 0.05% frequency [57% non-synonymous (NS), 42% synonymous and 1% gain or loss of stop codon or splice site variant] in 16 751 genes with the strongest associations observed in SPARCL1 on 4q22.1 (rs13051, Ala49Asp, OR = 0.78, P = 1.8 × 10(-6)) and PTPRR on 12q15 (rs73341069, Val239Ile, OR = 1.62,
PTPRR regulates ERK dephosphorylation in depression mice model.
New
Zhang et al., Taiyuan, China. In J Affect Disord, Jan 2016
BACKGROUND: The Protein tyrosine phosphatase receptor type R (PTPRR), which regulates the dephosphorylation of the downstream mitogen-activated protein kinase (MAPK) steering cell proliferation, apoptosis and synaptic plasticity, may be involved in the pathogenesis of depression.
Protein tyrosine phosphatase receptor R and Z1 expression as independent prognostic indicators in oral squamous cell carcinoma.
New
Ziółkowski et al., Wrocław, Poland. In Head Neck, Dec 2015
Although substantial previous data have revealed the role of several protein tyrosine phosphatases (PTPs) in various cancers, the function of protein tyrosine phosphatase receptor R (PTPRR) and protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) proteins in oral cavity squamous cell carcinoma (SCC) has not been studied to date.
Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.
New
Inoko et al., Yokohama, Japan. In J Hum Genet, Oct 2015
These regions contained the HLA, TSPAN8 and PTPRR genes.
Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
Hendriks et al., Nijmegen, Netherlands. In Mol Brain, 2014
Here we report that the tyrosine-specific MAPK-phosphatase PTPRR plays a role in coordinating the activity of this regulatory loop.
Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells.
Elliott et al., Newcastle upon Tyne, United Kingdom. In Bmc Cancer, 2014
RESULTS: We find the PTGER4 and TSPYL2 genes are up-regulated by androgen stimulation and the ADCY1, OPKR1, TRIB1, SPRY1 and PTPRR are down-regulated by androgens.
Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions - a Taiwanese Gynecologic Oncology Group (TGOG) study.
Yu et al., Kao-hsiung, Taiwan. In Gynecol Oncol, 2014
OBJECTIVE: Our previous work revealed that host genes ZNF582, PTPRR, PAX1, and SOX1 are highly methylated in cervical intraepithelial neoplasias grade 3 or worse (CIN3(+)).
Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters.
Rujescu et al., Brescia, Italy. In Eur Arch Psychiatry Clin Neurosci, 2014
Our primary aim was to investigate the potential modulation of several single-nucleotide polymorphisms (SNPs) of the same previously investigated genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) on personality traits, as measured with the Temperament and Character Inventory (TCI), in a German sample composed of 287 healthy subjects (males: 123, 42.9 %; mean age: 45.2 ± 14.9 years) and in 111 psychiatric patients who attempted suicide (males: 43, 38.6 %; mean age: 39.2 ± 13.6 years).
Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory.
Van der Zee et al., Nijmegen, Netherlands. In Behav Brain Res, 2014
Mouse gene Ptprr encodes multiple protein tyrosine phosphatase receptor type R (PTPRR) isoforms that negatively regulate mitogen-activated protein kinase (MAPK) signaling pathways.
Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues.
Ziółkowski et al., Wrocław, Poland. In Histol Histopathol, 2014
These results are not in line with recently published data, showing that genetic coding for PTPRR and PTPRZ1 were hypermethylated in CRC's.
High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.
Lai et al., Taipei, Taiwan. In Int J Gynecol Cancer, 2014
OBJECTIVE: This study aimed to investigate the status of DNA methylation of 6 genes, LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582, previously found from squamous cell carcinomas in adenocarcinomas (ACs) of the uterine cervix.
Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells.
Hamid et al., Kepala Batas, Malaysia. In Int J Mol Med, 2014
The caspase 10, apoptosis-related cysteine peptidase (CASP10) gene was activated and the protein tyrosine phosphatase, receptor type, R (PTPRR) and myocyte enhancer factor 2C (MEF2C) genes were upregulated in the classical MAPK and p38 MAPK pathways.
Gender-specific role of the protein tyrosine phosphatase receptor type R gene in major depressive disorder.
GeneRIF
Xu et al., Beijing, China. In J Affect Disord, 2012
the protein tyrosine phosphatase receptor type R gene may play a role in conferring risk of major depressive disorder in females
PTPBR7 binding proteins in myelinating neurons of the mouse brain.
GeneRIF
Hendriks et al., Nijmegen, Netherlands. In Int J Biol Sci, 2010
Results support the suggested link between PTPRR isoforms and cerebellar calcium ion homeostasis, and suggest an additional role in the process of cell-cell adhesion
Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer.
Review
Sasiadek et al., Wrocław, Poland. In Acta Biochim Pol, 2010
Also, alterations in the expression of these genes, such as decreased expression of PTPRR, PTPRO, PTPRG and PTPRD, mediated by epigenetic mechanisms have been observed in a variety of tumors.
PTPRR, cerebellum, and motor coordination.
Review
Manto et al., Bonn, Germany. In Cerebellum, 2009
The protein products of the neuronal mouse gene PTPRR are physiological regulators of mitogen-activated protein kinase (MAPK) activities.
PTPRR protein tyrosine phosphatase isoforms and locomotion of vesicles and mice.
Review
Fransen et al., Nijmegen, Netherlands. In Cerebellum, 2009
In this review, we present current knowledge on the PTPRR subfamily of classical PTPs that is expressed in neuronal cells and comprises receptor-type (PTPBR7, PTP-SL) as well as cytosolic (PTPPBSgamma-37, PTPPBSgamma-42) isoforms.
The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.
GeneRIF
Marra et al., Zürich, Switzerland. In Mol Cancer, 2008
expression of the PTPRR-1 isoform was inactivated in colorectal cancer cells as a result of de novo CpG island methylation and enrichment of transcription-repressive histone-tail marks, mainly H3K27me3
Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity.
GeneRIF
Hendriks et al., Nijmegen, Netherlands. In Biochim Biophys Acta, 2008
PTP-SL, like PTPBR7, is a single membrane-spanning receptor-type protein tyrosine phosphatases.
Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice.
GeneRIF
Hendriks et al., Nijmegen, Netherlands. In J Neurochem, 2007
Ptprr-/- mice displayed ataxia characterized by defects in fine motor coordination and balance skills.
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