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Protein tyrosine phosphatase, receptor type, G

PTPRG, RPTPgamma
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RPTPbeta, CAN, HAD, FHIT, Pts
Papers on PTPRG
Expression analysis of four long noncoding RNAs in breast cancer.
New
Ghafouri-Fard et al., Tehrān, Iran. In Tumour Biol, Oct 2015
In this study, we analyzed expression of four long noncoding RNAs (lncRNAs) namely SOX2OT, PTPRG-AS1, ANRASSF1, and ANRIL in 38 breast cancer tissues and their adjacent noncancerous tissues (ANCTs).
De novo mutations from sporadic schizophrenia cases highlight important signaling genes in an independent sample.
New
Malaspina et al., New York City, United States. In Schizophr Res, Aug 2015
First, whole exome sequencing was conducted to identify disruptive de novo mutations in 14 complete parent-offspring trios with sporadic schizophrenia from Jerusalem, which identified 5 sporadic cases with de novo gene mutations in 5 different genes (PTPRG, TGM5, SLC39A13, BTK, CDKN3).
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.
New
COMPASS and METASTROKE Consortia et al., Seattle, United States. In Stroke, Aug 2015
Nominal associations (P<10(-6)) for total or ischemic stroke were observed for 18 variants in or near genes implicated in cell cycle/mRNA presplicing (PTPRG, CDC5L), platelet function (HPS4), blood-brain barrier permeability (CLDN17), immune response (ELTD1, WDFY4, and IL1F10-IL1RN), and histone modification (HDAC9).
Unsupervised explorative data analysis of normal human leukocytes and BCR/ABL positive leukemic cells mid-infrared spectra.
New
Sorio et al., Verona, Italy. In Analyst, Aug 2015
We analyzed by microFTIR human polymorphonuclear neutrophil (PMNs) leukocytes, mouse-derived parental Ba/F3 cells (Ba/F3#PAR), Ba/F3 cells transfected with p210(BCR/ABL) (Ba/F3#WT) and expressing high levels of protein tyrosine kinase (PTK), and human-derived BCR/ABL positive K562 leukemic cell sub-clones engineered to differently express receptor-type tyrosine-protein phosphatase gamma (PTPRG).
Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers.
New
Sjöblom et al., Uppsala, Sweden. In Am J Pathol, Jun 2015
In addition to known vascular and stromal markers such as PDGFRB, we observed stromal expression of PTK6 and TNS1 and vascular expression of INSR, PTPRF, PTPRG, PTPRU, and TNS1, of which INSR emerged as a tumor-specific vessel marker.
PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma.
New
Lung et al., Hong Kong, Hong Kong. In Oncotarget, Jun 2015
Protein Tyrosine Phosphatase, Receptor Type G (PTPRG) was identified as a candidate tumor suppressor gene in nasopharyngeal carcinoma (NPC).
Genome-wide gene pathway analysis of psychotic illness symptom dimensions based on a new schizophrenia-specific model of the OPCRIT.
New
Fanous et al., United States. In Schizophr Res, May 2015
Of particular interest are findings for PTPRG and WBP1L, both of which were previously implicated by the Psychiatric Genomics Consortium study of SCZ; results from this study suggest that variants in these genes might also act as modifiers of SCZ symptoms.
Carbonic anhydrase related proteins: molecular biology and evolution.
Review
Parkkila et al., Tampere, Finland. In Subcell Biochem, 2013
The CA-like domains of receptor-type protein tyrosine phosphatases (PTPR) are found only in PTPRG and PTPRZ.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
GeneRIF
Sheriff et al., Princeton, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
found that the RPTP-gamma, RPTP-gamma(V948I, S970T) and RPTP-gamma(C858S, S970T) proteins could be stored at 193 K in their respective crystallization buffers without affecting crystallization or crystal quality
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
GeneRIF
Boer et al., Leiden, Netherlands. In Eur J Hum Genet, 2011
Tumor-specific methylation of the first intron of the receptor protein-tyrosine phosphatase gamma gene was found in both sporadic and Lynch syndrome colorectal cancers.
Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer.
Review
Sasiadek et al., Wrocław, Poland. In Acta Biochim Pol, 2010
Mutational analysis of the tyrosine phosphatome in CRCs has identified somatic mutations in PTPRG, PTPRT, PTPN3, PTPN13 and PTPN14.
Protein tyrosine phosphatase receptor type {gamma} is a functional tumor suppressor gene specifically downregulated in chronic myeloid leukemia.
GeneRIF
Sorio et al., Verona, Italy. In Cancer Res, 2010
Downregulation of Protein tyrosine phosphatase receptor type {gamma} is associated with chronic myeloid leukemia.
E2-2 protein and Fuchs's corneal dystrophy.
Impact
Edwards et al., Rochester, United States. In N Engl J Med, 2010
Alleles in the gene encoding protein tyrosine phosphatase receptor type G (PTPRG) were associated with FCD (P=4.0x10(-7)), but the association did not reach genomewide significance.
Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.
GeneRIF
Lin et al., Columbus, United States. In Anticancer Res, 2010
PTPRG inhibited breast tumor formation in vivo; PTPRG may up-regulate p21(cip) and p27(kip) proteins through the ERK1/2 pathway.
The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.
GeneRIF
Watkins et al., Kansas City, United States. In Proc Natl Acad Sci U S A, 2010
findings implicate PTPRG, PTPRZ and CNTNs as a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Impact
Knapp et al., Oxford, United Kingdom. In Cell, 2009
We propose a "head-to-toe" dimerization model for RPTPgamma/zeta that is distinct from the "inhibitory wedge" model and that provides a molecular basis for inhibitory regulation.
Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.
Impact
GeneRIF
Tensen et al., Leiden, Netherlands. In J Clin Oncol, 2005
Promoter hypermethylation of PTPRG is associated with cutaneous T-cell lymphoma
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Impact
Velculescu et al., Baltimore, United States. In Science, 2004
A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and gastric cancers.
Protein tyrosine phosphatase beta, a receptor for Helicobacter pylori vacA toxin.
Review
Hirayama, Nagasaki, Japan. In Keio J Med, 2002
The overexpression of RPTP beta conferred VacA sensitivity on BHK-21 cells transfected with the RPTP beta cDNA, consistent with RPTP gamma acting as a receptor for VacA.
Hot spots for molecular genetic alterations in lung cancer.
Review
Bepler et al., Durham, United States. In In Vivo, 1998
Candidate genes in these regions include the von Hippel-Lindau (VHL) gene at 3p25, the ubiquitin-activating enzyme homologue (UBE1L at 3p21, the genes for the dinucleoside polyphosphate hydrolase FHIT and receptor protein-tyrosine phosphatase gamma PTPRG at 3p14.2, the genes for tropomyosin beta (TM1) and a talin homologue (talin) at 9p21, and the H-ras gene at 11p15.
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