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Protein tyrosine phosphatase, non-receptor type 21

PTPD1, PTPN21, Protein-tyrosine phosphatase D1, PTP2E
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Pts, Src, PTPH1, Ezrin, Protein-Tyrosine-Phosphatase
Papers on PTPD1
Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic cell transplantation.
Huang et al., Hangzhou, China. In Oncotarget, Nov 2015
The relapsed samples were also enriched in signaling factor mutations, including KRAS, PTPN21, MYC and USP54.
Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Wang et al., Taipei, Taiwan. In Structure, May 2015
The WPD loop necessary for catalysis is present in all members but not PTPN21.
PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling.
Song et al., Hong Kong, Hong Kong. In Int J Biochem Cell Biol, Apr 2015
Here we combined eQTL and molecular analyses to identify an association between two seemingly non-associated genes in brain expression data from BXD inbred mice, namely Ptpn21 and Nrg3.
Identification of a novel stress regulated FERM domain containing cytosolic protein having PTP activity in Setaria cervi, a bovine filarial parasite.
Rathaur et al., Benares, India. In Biochem Biophys Res Commun, Mar 2015
The MALDI-MS/MS analysis of the purified protein revealed 16 peptide peaks showing nearest match to Brugia malayi Moesin/ezrin/radixin homolog 1 protein and one peptide showing significant similarity with a region lying in the catalytic domain of human PTPD1.
Comprehensive analysis of the whole transcriptomes from two different pig breeds using RNA-Seq method.
Oczkowicz et al., Bielsko-Biała, Poland. In Anim Genet, 2014
In PL pigs, we identified up-regulation of several genes that play crucial roles in reproduction: female gamete generation (BDP1, PTPN21, USP9X), fertilization (EGFR) and embryonic development (CPEB4).
Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.
Pei et al., Columbus, United States. In Biochemistry, 2014
The sequence selectivity of 14 classical protein-tyrosine phosphatases (PTPs) (PTPRA, PTPRB, PTPRC, PTPRD, PTPRO, PTP1B, SHP-1, SHP-2, HePTP, PTP-PEST, TCPTP, PTPH1, PTPD1, and PTPD2) was systematically profiled by screening their catalytic domains against combinatorial peptide libraries.
Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation.
Bastiaens et al., Madrid, Spain. In Plos One, 2013
Here, we have studied the intracellular dynamics of PTPD1, a FERM (four-point-one, ezrin, radixin, moesin) domain-containing PTP that is over expressed in cancer cells and potentiates EGFR signalling.
Polarity gene alterations in pure invasive micropapillary carcinomas of the breast.
Vincent-Salomon et al., In Breast Cancer Res, 2013
Whole-exome sequencing combined with RNA sequencing of IMPC allowed us to identify somatic mutations in genes involved in polarity, DNAH9 and FMN2 (8% and 2%, respectively) or ciliogenesis, BBS12 and BBS9 (2% each) or genes coding for endoplasmic reticulum protein, HSP90B1 and SPTLC3 (2% each) and cytoskeleton, UBR4 and PTPN21 (2% each), regardless of the genomic subset.
Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.
International Schizophrenia Consortium et al., Richmond, United States. In Schizophr Res, 2011
The results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted.
PTPD1 supports receptor stability and mitogenic signaling in bladder cancer cells.
Feliciello et al., Napoli, Italy. In J Biol Chem, 2011
PTPD1 is a novel component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells
Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells.
Chao et al., Taiwan. In Biochem Pharmacol, 2010
We identified nine genes (NAPA, CITED2, CABIN1, ADM, HIST1H1A, EHD1, MARK2, PTPN21, and MVD), which were consistently upregulated in two cisplatin-resistant HeLa cell lines.
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Klein et al., Bethesda, United States. In J Biol Chem, 2009
Expression of Ptpn21 decreases 8-fold at night in the rat pineal gland relative to day values. This appears to reflect negative effects of norepinephrine acting through a cyclic AMP mechanism.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Knapp et al., Oxford, United Kingdom. In Cell, 2009
Enzymatic assays revealed vast differences in PTP catalytic activity and identified PTPD1, PTPD2, and HDPTP as catalytically inert protein phosphatases.
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
Feliciello et al., Napoli, Italy. In J Biol Chem, 2008
PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
Gebert et al., Heidelberg, Germany. In Bmc Cancer, 2007
In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency; the highest mutation frequency among 16 PTP genes
Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.
Simmonds et al., Birmingham, United Kingdom. In Clin Endocrinol (oxf), 2006
PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-1, on chromosome 14q31.
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