Genomic profiling of invasive melanoma cell lines by array comparative genomic hybridization.
Debrecen, Hungary. In Melanoma Res, Jan 2016
Invasive primary cell lines showed high frequencies of CNAs, including the loss of 7q and gain of 12q chromosomal regions targeting PTPN12, ADAM22, FZD1, TFPI2, GNG11, COL1A2, SMURF1, VGF, RELN and GLIPR1 genes.
Uncovering a tumor suppressor for triple-negative breast cancers.
Boston, United States. In Cell, 2011
Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.