Critical Function of γH2A in S-Phase.
Los Angeles, United States. In Plos Genet, Sep 2015
These requirements for γH2A were traced to its role in docking with Brc1, which is a 6-BRCT-domain protein that is structurally related to budding yeast Rtt107 and mammalian PTIP.
53BP1: pro choice in DNA repair.
New York City, United States. In Trends Cell Biol, 2014
Here we review these aspects of 53BP1 and discuss new data revealing how 53BP1 is loaded onto chromatin and uses its interacting factors Rif1 and PTIP to promote NHEJ and inhibit HDR.