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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PAX interacting

PTIP, PAXIP1
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, PAX2, Atm, CAN, 53BP1
Papers on PTIP
A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
New
Daniel et al., Copenhagen, Denmark. In Genes Dev, Feb 2016
Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-associated DNA damage and is promoted by the BRCT domain-containing PTIP (Pax transactivation domain-interacting protein).
Kabuki syndrome: expanding the phenotype to include microphthalmia and anophthalmia.
New
Reardon et al., Manchester, United Kingdom. In Clin Dysmorphol, Oct 2015
We postulate that Kabuki syndrome may produce this type of ocular phenotype as a result of extensive interaction between KMT2D, WAR complex proteins and PAXIP1.
Critical Function of γH2A in S-Phase.
New
Russell et al., Los Angeles, United States. In Plos Genet, Sep 2015
These requirements for γH2A were traced to its role in docking with Brc1, which is a 6-BRCT-domain protein that is structurally related to budding yeast Rtt107 and mammalian PTIP.
MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.
New
Impact
Jacobs et al., Amsterdam, Netherlands. In Nature, Jun 2015
End resection blocks NHEJ while committing to homology-directed repair, and is under the control of 53BP1, RIF1 and PTIP.
A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.
New
Coppola et al., New Brunswick, United States. In Jama Neurol, Apr 2015
In addition, 2 suggestive candidate genes, DYSF (P=5.53×10(-5)) and PAXIP1 (P=2.26×10(-4)), were highlighted in patients with AD and differentially expressed in AD brain.
The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.
New
Patel et al., Ann Arbor, United States. In J Biol Chem, Apr 2015
PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation.
The PTIP-Associated Histone Methyltransferase Complex Prevents Stress-Induced Maladaptive Cardiac Remodeling.
Dandar et al., Kalamazoo, United States. In Plos One, 2014
To demonstrate the importance of the epigenome in HF, we targeted the PTIP-associated histone methyltransferase complex in adult cardiac myocytes.
Mechanisms of gene activation and repression by Pax proteins in the developing kidney.
Review
Dressler et al., Ann Arbor, United States. In Pediatr Nephrol, 2014
Through interactions with the adaptor Pax transactivation-domain interacting protein (PTIP), Pax proteins can recruit members of the Trithorax family of histone methyltransferases to imprint activating epigenetic marks on chromatin.
53BP1: pro choice in DNA repair.
Review
de Lange et al., New York City, United States. In Trends Cell Biol, 2014
Here we review these aspects of 53BP1 and discuss new data revealing how 53BP1 is loaded onto chromatin and uses its interacting factors Rif1 and PTIP to promote NHEJ and inhibit HDR.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Impact
Nussenzweig et al., Bethesda, United States. In Cell, 2013
53BP18A recruits RIF1 but fails to recruit the DDR protein PTIP to DSBs, and disruption of PTIP phenocopies 53BP18A.
Brc1 links replication stress response and centromere function.
Review
Russell et al., Los Angeles, United States. In Cell Cycle, 2013
This compact arrangement of localization domains may be a shared feature of other γH2A-binding proteins, including Rtt107, PTIP and Mdc1.
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Impact
Nussenzweig et al., Bethesda, United States. In Immunity, 2013
Here we have shown that PAXIP1 (also known as PTIP), a protein associated with MLL3 and MLL4 methyltransferase and the DNA damage response, regulates RAG-mediated cleavage and repair during V(D)J recombination in CD4(+) CD8(+) DP thymocytes.
Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway.
GeneRIF
Li et al., Hefei, China. In Febs Lett, 2012
a new clue to identify the role of PTIP in DNA damage pathway
Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.
GeneRIF
Dressler et al., Ann Arbor, United States. In Mol Cell Biol, 2011
PTIP stabilizes the Pax5 DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination.
Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.
GeneRIF
Dressler et al., Ann Arbor, United States. In Plos Genet, 2010
Data show that loss of PTIP resulting in subtle changes in gene expression patterns and lower H3K4 methylation.
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Impact
GeneRIF
Nussenzweig et al., Bethesda, United States. In Science, 2010
PTIP accumulation at double stranded breaks contributes to class switch recombination and genome stability independently of Igh switch transcription
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.
Impact
GeneRIF
Ge et al., Bethesda, United States. In Cell Metab, 2009
PTIP controls expression of PPARgamma and C/EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis.
Control of histone methylation and genome stability by PTIP.
Review
Rouse et al., Dundee, United Kingdom. In Embo Rep, 2009
PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication.
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