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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

PAX interacting

PTIP, PAXIP1
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PTIP
Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway.
GeneRIF
Li et al., Hefei, China. In Febs Lett, 2012
a new clue to identify the role of PTIP in DNA damage pathway
Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.
GeneRIF
Dressler et al., Ann Arbor, United States. In Mol Cell Biol, 2011
PTIP stabilizes the Pax5 DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination.
Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.
GeneRIF
Dressler et al., Ann Arbor, United States. In Plos Genet, 2010
Data show that loss of PTIP resulting in subtle changes in gene expression patterns and lower H3K4 methylation.
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Impact
GeneRIF
Nussenzweig et al., Bethesda, United States. In Science, 2010
PTIP accumulation at double stranded breaks contributes to class switch recombination and genome stability independently of Igh switch transcription
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.
Impact
GeneRIF
Ge et al., Bethesda, United States. In Cell Metab, 2009
PTIP controls expression of PPARgamma and C/EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis.
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