Oxidative stress and mitochondrial dysfunction in sepsis: a potential therapy with mitochondria-targeted antioxidants.more suppliers
In PLoS ONE, 2008
... phospho-Akt (Ser473), p38 MAPK, phospho-p38 MAPK (Thr180/Tyr182), JNK, phospho-JNK (Thr183/Tyr185), ERK1/2, phospho-ERK1/2 (Thr185/Tyr187), PTEN, and phospho-PTEN (Ser380) were purchased from Cell Signaling Technology, Inc ...
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling.
Leuven, Belgium. In Biochim Biophys Acta, Feb 2016
An important aspect of this is the identification of several major oncogenes, including Bcl-2, Bcl-XL, Mcl-1, PKB/Akt, and Ras, and tumor suppressors, such as p53, PTEN, PML, BRCA1, and Beclin 1, as direct and critical regulators of Ca(2+)-transport systems located at the ER membranes, including IP3 receptors and SERCA Ca(2+) pumps.
Reaching the brain: Advances in optic nerve regeneration.
In Exp Neurol, Jan 2016
More recently, some degree of regeneration has been achieved through the optic nerve itself by factors associated with intraocular inflammation (oncomodulin) or by altering levels of particular transcription factors (Klf-4, -9, c-myc), cell-intrinsic suppressors of axon growth (PTEN, SOCS3), receptors to cell-extrinsic inhibitors of axon growth (Nogo receptor, LAR, PTP-σ) or the intracellular signaling pathway activated by these receptors (RhoA).
The critical roles of miR-21 in anti-cancer effects of curcumin.
Australia. In Ann Transl Med, Dec 2015
Several downstream pathways of miR-21 have been identified including phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), programmed cell death protein 4 (PDCD4) and NF-κB pathways.
The Role of PTEN in Myeloid Malignancies.
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Orbassano, Italy. In Hematol Rep, Dec 2015
PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor suppressor in the development of myeloid malignancies, in particular acute myeloid leukemia and myeloproliferative disorders.