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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Nuclear receptor coactivator 4

PTC3, ARA70, ELE1, RFG
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009] (from NCBI)
Papers using PTC3 antibodies
Thyroid tumorigenesis
Supplier
Franc B et al., In British Journal of Cancer, 1993
... RET/PTC3, E7 transgenic and C57Bl/6 wild-type mice ...
Papers on PTC3
Promoter variants in the MSMB gene associated with prostate cancer regulate MSMB/NCOA4 fusion transcripts.
GeneRIF
Dean et al., Frederick, United States. In Hum Genet, 2012
Computational network analysis reveals that the MSMB gene is functionally connected to NCOA4 and the androgen receptor signaling pathway. The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects
Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer.
GeneRIF
Lee et al., New York City, United States. In Breast Cancer Res Treat, 2011
High ARA70alpha inhibited cell proliferation, and that ARA70beta promotes proliferation in breast cancer.
Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.
GeneRIF
Freedman et al., Boston, United States. In Plos Genet, 2010
Suppression of MSMB expression or NCOA4 overexpression promotes anchorage-independent growth of prostate epithelial cells.
Variable expression of nuclear receptor coactivator 4 (NcoA4) during mouse embryonic development.
GeneRIF
Brown et al., Toronto, Canada. In J Histochem Cytochem, 2010
Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor, during development.
Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer.
GeneRIF
Lee et al., New York City, United States. In Am J Pathol, 2010
ARA70alpha functions as a tumor suppressor gene
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