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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Patched 2

PTC2, PTCH2
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: RET, PTC3, Shh, Gli, Smo
Papers on PTC2
Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study.
New
Hui et al., New Haven, United States. In Hum Pathol, 30 Sep 2014
Genes mapping to the regions of loss include CHEK2, EWS, NF2, PDGFB, and MAP3K7IP1 on chromosome 22q, HEI10 on chromosome 14q, and succinate dehydrogenase subunit B, E2F2, ARID1A KPNA6, EIF3S2 , PTCH2, and PIK3R3 on chromosome 1p.
SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties.
New
Toledo et al., São Paulo, Brazil. In Childs Nerv Syst, Jul 2014
METHODS: We quantified, by qPCR in 40 MB tumor samples, the expression of genes in HH (PTCH1, PTCH2, and GLI1), WNT (APC, CTNNB1, WIF1, and DKK2), and NOTCH pathways (NOTCH2 and HES1), which have a crucial role in development, and genes as MYCC, MYCN, and TERT, correlating this findings to patient's clinicopathological characteristics.
Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.
New
Zaphiropoulos et al., Huddinge, Sweden. In Mol Oncol, Jul 2014
Conversely, GLI1AS overexpression decreased the levels of GLI1, its target genes PTCH1 and PTCH2, and cellular proliferation.
Early-onset acral basal cell carcinomas in Gorlin syndrome.
New
Haple et al., Madrid, Spain. In Br J Dermatol, Jun 2014
GS is due to mutations in the genes PTCH1, PTCH2 and SUFU involved in the hedgehog pathway (4-6).
Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia.
New
Rogler et al., In Hum Mol Genet, Feb 2014
Pathway analysis identified regulated genes that function in skeletal development, hair development and hematopoietic cell differentiation including PTCH2 and SOX4 among others, linked to major CHH phenotypes.
Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning.
New
Allen et al., Ann Arbor, United States. In Development, Aug 2013
Unique to vertebrates are two additional HH-binding antagonists that are induced by HH signaling, HHIP1 and the PTCH1 homologue PTCH2.
The effect of dietary supplementation with phytase transgenic maize and different concentrations of non-phytate phosphorus on the performance of laying hens.
Wang et al., Beijing, China. In Br Poult Sci, 2012
The layers in the control group (control) were given a basal diet with 0.36% non-phytate P (NPP), while the treatment groups received diets containing 360 U of exogenous phytase/kg with 0.26% NPP (EP) or 360 phytase U of PTC/kg diet with 0.26% (PTC1), 0.21% (PTC2) or 0.16% (PTC3) NPP. 3. The results showed that there was no significant difference in egg production, average daily feed intake, feed efficiency, rate of broken or soft-shell egg production or egg mass among the treatments.
Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish.
Ingham et al., Tianjin, China. In Biol Open, 2012
Using a null allele of the gli2a gene induced by targeted mutagenesis, we show that Gli2a is completely dispensable in the fish but acts redundantly with Gli1 to regulate expression of known Hh targets, such as ptch2, prdm1a and eng2a, in the myotome and neural tube.
Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features.
Sakamoto et al., Tokyo, Japan. In Plos One, 2012
PTCH2 and SUFU participate in the occurrence of GS-associated tumors, but their roles in KCOT development are unknown.
Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.
GeneRIF
Roehl et al., Sheffield, United Kingdom. In Mech Dev, 2011
The Hedgehog co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Review
Katoh et al., Japan. In Curr Mol Med, 2009
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin.
A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation.
GeneRIF
Wang et al., Beijing, China. In Am J Med Genet A, 2009
A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported.
Expanded progenitor populations, vitreo-retinal abnormalities, and Müller glial reactivity in the zebrafish leprechaun/patched2 retina.
GeneRIF
Gross et al., Austin, United States. In Bmc Dev Biol, 2008
Results indicate that Patched2-dependent Hh signaling does not likely play an integral role in neuronal cell fate decisions in the zebrafish retina.
A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese family.
GeneRIF
Wang et al., Beijing, China. In J Med Genet, 2008
PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS, resulting in the loss of PTCH2 inhibitory function in the Shh signalling pathway.
Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.
GeneRIF
van Eeden et al., Utrecht, Netherlands. In Bmc Dev Biol, 2007
The generation and characterization of the ptc1;ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway.
Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).
Review
Katoh et al., Tokyo, Japan. In Int J Mol Med, 2006
Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH) bind to PTCH1/PTCH or PTCH2 receptor to release Smoothened (SMO) signal transducer from Patched-dependent suppression.
Hedgehog signaling pathway and gastric cancer.
Review
Katoh et al., Japan. In Cancer Biol Ther, 2005
Human SHH, IHH, DHH (Hedgehog homologs), HHAT (Hedgehog acyltransferase), HHIP (Hedgehog-interacting protein), DISP1, DISP2, DISP3 (Dispatched homologs), PTCH1, PTCH2 (Patched homologs), SMO (Smoothened homolog), KIF27, KIF7 (Costal-2 homologs), STK36 (Fused homolog), SUFU (SuFu homolog), DZIP1 (Iguana homolog), GLI1, GLI2 and GLI3 (Cubitus interruptus homologs) are implicated in the Hedgehog signaling.
Carcinogenesis of basal cell carcinomas: genetics and molecular mechanisms.
Review
Lacour, Nice, France. In Br J Dermatol, 2002
Smoothened-activating mutations and PTCH2 mutations are also involved in BCC formation.
RET oncogene activation in papillary thyroid carcinoma.
Review
Asa et al., New Haven, United States. In Adv Anat Pathol, 2001
RET/PTC1 and RET/PTC3 are by far the most common rearrangements.
Loss of function effect of RET mutations causing Hirschsprung disease.
Impact
Bocciardi et al., Quarto, Italy. In Nat Genet, 1995
We have introduced three Hirschsprung (HSCR) mutations localized in the tyrosine kinase domain of RET into the RET/PTC2 chimaeric oncogene which is capable of transforming NIH3T3 mouse fibroblasts and of differentiating pC12 rat pheochromocytoma cells.
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