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Patched 2

This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: RET, PTC3, Shh, Gli, Smo
Papers on PTC2
Expression pattern of the Hedgehog signaling pathway in pituitary adenomas.
Yovos et al., Thessaloníki, Greece. In Neurosci Lett, 12 Feb 2016
We used a customized RT(2) Profiler PCR Array, to investigate the expression of genes related to Notch and Hedgehog signaling pathways (PTCH1, PTCH2, GLI1, GLI3, NOTCH3, JAG1, HES1, and HIP).
Molecular changes in endometriosis-associated ovarian clear cell carcinoma.
Ng et al., Boston, United States. In Eur J Cancer, Sep 2015
XRCC5, PTCH2, eEF1A2 and PPP1R14B were significantly overexpressed in OCCC and associated endometriosis, but not in benign endometriosis (p ⩽ 0.004).
Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.
Allen et al., Ann Arbor, United States. In J Cell Biol, Jul 2015
Vertebrate Hedgehog (HH) signaling is controlled by several ligand-binding antagonists including Patched-1 (PTCH1), PTCH2, and HH-interacting protein 1 (HHIP1), whose collective action is essential for proper HH pathway activity.
Identification of melanoma biomarkers based on network modules by integrating the human signaling network with microarrays.
Chen et al., Shanghai, China. In J Cancer Res Ther, 2014
Finally, we acquired six significant molecular biomarkers, namely, module 10 (CALM3, Ca 2+ , PKC, PDGFRA, phospholipase-g, PIB5PA, and phosphatidylinositol-3-kinase), module 14 (SRC, Src homology 2 domain-containing [SHC], SAM68, GIT1, transcription factor-4, CBLB, GRB2, VAV2, LCK, YES, PTCH2, downstream of tyrosine kinase [DOK], and KIT), module 16 (ELK3, p85beta, SHC, ZFYVE9, TGFBR1, TGFBR2, CITED1, SH3KBP1, HCK, DOK, and KIT), module 45 (RB, CCND3, CCNA2, CDK4, and CDK6), module 75 (PCNA, CDK4, and CCND1), and module 114 (PSD93, NMDAR, and FYN).
Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study.
Hui et al., New Haven, United States. In Hum Pathol, 2014
Genes mapping to the regions of loss include CHEK2, EWS, NF2, PDGFB, and MAP3K7IP1 on chromosome 22q, HEI10 on chromosome 14q, and succinate dehydrogenase subunit B, E2F2, ARID1A KPNA6, EIF3S2 , PTCH2, and PIK3R3 on chromosome 1p.
SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties.
Toledo et al., São Paulo, Brazil. In Childs Nerv Syst, 2014
METHODS: We quantified, by qPCR in 40 MB tumor samples, the expression of genes in HH (PTCH1, PTCH2, and GLI1), WNT (APC, CTNNB1, WIF1, and DKK2), and NOTCH pathways (NOTCH2 and HES1), which have a crucial role in development, and genes as MYCC, MYCN, and TERT, correlating this findings to patient's clinicopathological characteristics.
Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.
Zaphiropoulos et al., Huddinge, Sweden. In Mol Oncol, 2014
Conversely, GLI1AS overexpression decreased the levels of GLI1, its target genes PTCH1 and PTCH2, and cellular proliferation.
Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia.
Rogler et al., In Hum Mol Genet, 2014
Pathway analysis identified regulated genes that function in skeletal development, hair development and hematopoietic cell differentiation including PTCH2 and SOX4 among others, linked to major CHH phenotypes.
Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.
Miyashita et al., Chiba, Japan. In Fam Cancer, 2013
Recently, a Chinese family with NBCCS carrying a missense mutation in PTCH2, a close homolog of PTCH1, was reported.
Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning.
Allen et al., Ann Arbor, United States. In Development, 2013
Unique to vertebrates are two additional HH-binding antagonists that are induced by HH signaling, HHIP1 and the PTCH1 homologue PTCH2.
Heat-shock-mediated conditional regulation of hedgehog/gli signaling in zebrafish.
Karlstrom et al., Amherst Center, United States. In Dev Dyn, 2013
A ptch2 promoter element was used to generate new reporter lines that allow clear visualization of Hh responding cells throughout the life cycle, including graded Hh responses in the embryonic central nervous system.
Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features.
Sakamoto et al., Tokyo, Japan. In Plos One, 2012
PTCH2 and SUFU participate in the occurrence of GS-associated tumors, but their roles in KCOT development are unknown.
The effect of dietary supplementation with phytase transgenic maize and different concentrations of non-phytate phosphorus on the performance of laying hens.
Wang et al., Beijing, China. In Br Poult Sci, 2012
The layers in the control group (control) were given a basal diet with 0.36% non-phytate P (NPP), while the treatment groups received diets containing 360 U of exogenous phytase/kg with 0.26% NPP (EP) or 360 phytase U of PTC/kg diet with 0.26% (PTC1), 0.21% (PTC2) or 0.16% (PTC3) NPP. 3. The results showed that there was no significant difference in egg production, average daily feed intake, feed efficiency, rate of broken or soft-shell egg production or egg mass among the treatments.
Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish.
Ingham et al., Tianjin, China. In Biol Open, 2012
Using a null allele of the gli2a gene induced by targeted mutagenesis, we show that Gli2a is completely dispensable in the fish but acts redundantly with Gli1 to regulate expression of known Hh targets, such as ptch2, prdm1a and eng2a, in the myotome and neural tube.
Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.
Roehl et al., Sheffield, United Kingdom. In Mech Dev, 2011
The Hedgehog co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.
A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation.
Wang et al., Beijing, China. In Am J Med Genet A, 2009
A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported.
Expanded progenitor populations, vitreo-retinal abnormalities, and Müller glial reactivity in the zebrafish leprechaun/patched2 retina.
Gross et al., Austin, United States. In Bmc Dev Biol, 2008
Results indicate that Patched2-dependent Hh signaling does not likely play an integral role in neuronal cell fate decisions in the zebrafish retina.
A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese family.
Wang et al., Beijing, China. In J Med Genet, 2008
PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS, resulting in the loss of PTCH2 inhibitory function in the Shh signalling pathway.
Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.
van Eeden et al., Utrecht, Netherlands. In Bmc Dev Biol, 2007
The generation and characterization of the ptc1;ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway.
Loss of function effect of RET mutations causing Hirschsprung disease.
Bocciardi et al., Quarto, Italy. In Nat Genet, 1995
We have introduced three Hirschsprung (HSCR) mutations localized in the tyrosine kinase domain of RET into the RET/PTC2 chimaeric oncogene which is capable of transforming NIH3T3 mouse fibroblasts and of differentiating pC12 rat pheochromocytoma cells.
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