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Polypyrimidine tract binding protein 1

PTB, Heterogeneous-Nuclear Ribonucleoprotein, Polypyrimidine Tract-Binding Protein
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, AGE
Papers using PTB antibodies
Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells.
Supplier
Ryu Wang-Shick, In PLoS ONE, 2005
... Antisera for western blot to hnRNP I (PTB) was purchased from Santa Cruz Biotechnology, mouse monoclonal antibodies to ...
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
Supplier
Tarn Woan-Yuh et al., In The Journal of Cell Biology, 2003
... The His-tagged PTB expression vector was constructed by cloning the human PTB-coding region into pET-32a (QIAGEN).
Papers on PTB
The Clathrin Adaptor Proteins ARH, Dab2 and Numb Play Distinct Roles in NPC1L1- versus LDL Receptor-mediated Cholesterol Uptake.
New
Song et al., China. In J Biol Chem, 20 Nov 2014
The ARH, Dab2 and Numb contain a homogeneous phosphotyrosine binding (PTB) domain that directly binds the endocytic motifs.
Src Homology 2 Domain Containing Protein 5 (SH2D5) Binds the Breakpoint Cluster Region Protein, BCR, and Regulates Levels of Rac1-GTP*
New
Pawson et al., Toronto, Canada. In J Biol Chem, 20 Nov 2014
UNLABELLED: SH2D5 is a mammalian-specific, uncharacterized adaptor-like protein that contains an N-terminal phosphotyrosine binding (PTB) domain and a C-terminal Src Homology 2 (SH2) domain.
Inhibition of Host Protein Synthesis by Sindbis Virus: Correlation with Viral Rna Replication and Release of Nuclear Proteins to the Cytoplasm.
New
Carrasco et al., Madrid, Spain. In Cell Microbiol, 20 Nov 2014
Exit of nuclear proteins including TIA-1 and PTB is clearly detected in SINV-infected cells, but not upon the expression of nsPs, even when the defective replicon was complemented.
RBM24 Is a Major Regulator of Muscle-Specific Alternative Splicing.
New
Braun et al., Bad Nauheim, Germany. In Dev Cell, 13 Nov 2014
Furthermore, we demonstrate that binding of RBM24 to an intronic splicing enhancer (ISE) is essential and sufficient to overcome repression of exon inclusion by an exonic splicing silencer (ESS) containing PTB and hnRNP A1/A2 binding sites.
Correlations between major risk factors and closely related Mycobacterium tuberculosis isolates grouped by three current enotyping procedures: a population-based study in northeast Mexico.
New
Said-Fernández/ et al., Mexico. In Mem Inst Oswaldo Cruz, 30 Sep 2014
Spearman's rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana- lysed.
Maternal nutrition interventions to improve maternal, newborn, and child health outcomes.
Review
New
Martorell et al., Atlanta, United States. In Nestle Nutr Inst Workshop Ser, Dec 2013
Maternal undernutrition affects a large proportion of women in many developing countries, but has received little attention as an important determinant of poor maternal, newborn, and child health (MNCH) outcomes such as intrauterine growth restriction, preterm birth (PTB), and maternal and infant morbidity and mortality.
Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.
Review
New
Pawson et al., Toronto, Canada. In Cold Spring Harb Perspect Biol, Dec 2013
Signaling effectors are recruited to these phosphotyrosine (pTyr) sites primarily through Src homology 2 (SH2) domains and pTyr-binding (PTB) domains.
Preterm birth and its long-term effects: methylation to mechanisms.
Review
New
Smith et al., Atlanta, United States. In Biology (basel), Dec 2013
This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
New
GeneRIF
Yoshida et al., Tokyo, Japan. In Cereb Cortex, Aug 2013
PTB depletion in the dorsal telencephalon is causally involved in the development of hydrocephalus. And PTB is important for the maintenance of Adherens Junctions in the neural stem cells of the dorsal telencephalon.
Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
New
Impact
Pawson et al., Toronto, Canada. In Nature, Aug 2013
Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 that contain phosphotyrosine (pTyr)-binding (PTB) domains.
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
New
Impact
Fu et al., Wuhan, China. In Cell, Feb 2013
Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Impact
Burge et al., Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.
The uterine myocyte as a target for prevention of preterm birth.
Review
Slater et al., Edmonton, Canada. In Facts Views Vis Obgyn, 2012
Preterm birth (PTB) remains the most common cause of neonatal morbidity and mortality as well as long-term disability.
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Impact
Lu et al., Houston, United States. In Nat Cell Biol, 2012
Nuclear PKM2 acts as a coactivator of β-catenin to induce c-Myc expression, resulting in the upregulation of GLUT1, LDHA and, in a positive feedback loop, PTB-dependent PKM2 expression.
Stem cell factor receptor/c-Kit: from basic science to clinical implications.
Review
Impact
Rönnstrand et al., Uppsala, Sweden. In Physiol Rev, 2012
Signaling proteins are recruited to activated c-Kit by certain interaction domains (e.g., SH2 and PTB) that specifically bind to phosphorylated tyrosine residues in the intracellular region of c-Kit.
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
GeneRIF
Holmberg et al., Umeå, Sweden. In Hum Mutat, 2012
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
GeneRIF
Black et al., Los Angeles, United States. In Nat Neurosci, 2012
The polypyrimidine tract binding proteins PTBP1 and PTBP2 repressed Psd-95 (also known as Dlg4) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.
GeneRIF
Hutvagner et al., Dundee, United Kingdom. In Plos One, 2011
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.
Preterm Cervical Ripening in humans.
Review
Dubicke et al., Stockholm, Sweden. In Facts Views Vis Obgyn, 2011
Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity.
Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.
GeneRIF
Yoshida et al., Tokyo, Japan. In Cell Cycle, 2011
PTB regulates the precise expression of CDK11(p58) through direct interaction with CDK11(p58) IRES and promotes M phase progression in ES cells.
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