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Polypyrimidine tract binding protein 1

PTB, Heterogeneous-Nuclear Ribonucleoprotein, Polypyrimidine Tract-Binding Protein
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, POLYMERASE
Papers using PTB antibodies
Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells.
Supplier
Ryu Wang-Shick, In PLoS ONE, 2005
... Antisera for western blot to hnRNP I (PTB) was purchased from Santa Cruz Biotechnology, mouse monoclonal antibodies to ...
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
Supplier
Tarn Woan-Yuh et al., In The Journal of Cell Biology, 2003
... The His-tagged PTB expression vector was constructed by cloning the human PTB-coding region into pET-32a (QIAGEN).
Papers on PTB
Polymorphisms in NR5A2, gene encoding Liver Receptor Homolog-1 are associated with Preterm Birth.
New
Murray et al., Buenos Aires, Argentina. In Pediatr Res, Feb 2016
BACKGROUND: Preterm birth (PTB) is a major cause of neonatal mortality and morbidity.
Differential expression of HLA-G and ILT-2 receptor in human tuberculosis: Localized versus disseminated disease.
New
Kanga et al., New Delhi, India. In Hum Immunol, Feb 2016
We investigated the expression profile of soluble and membrane bound HLA-G in pulmonary TB (PTB), TB pleural effusion (TB-PE, localized disease) and Miliary TB (disseminated form).
Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone.
New
Gomez-Lopez et al., Detroit, United States. In J Immunol, Feb 2016
UNASSIGNED: Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide.
IRGM gene polymorphisms and haplotypes associate with susceptibility of pulmonary tuberculosis in Chinese Hubei Han population.
New
Li et al., Wuhan, China. In Tuberculosis (edinb), Jan 2016
The objective of the study was to determine the association between IRGM polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in Chinese Hubei Han population.
Regulation of the expression and activity of Unr in mammalian cells.
Review
New
Catnaigh et al., Coventry, United Kingdom. In Biochem Soc Trans, Jan 2016
Translation of at least some unr transcripts can occur by internal initiation and is regulated in a cell-cycle-dependent manner; binding of PTB (polypyrimidine tract-binding protein) and Unr to the 5'-UTR inhibits translation, but these are displaced by heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNPC1/C2) during mitosis to stimulate translation.
A critical role of interleukin-1 in preterm labor.
Review
New
Chemtob et al., Montréal, Canada. In Cytokine Growth Factor Rev, Dec 2015
UNASSIGNED: Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden.
Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: updated meta-analysis.
Review
New
He et al., Nanning, China. In Int J Tuberc Lung Dis, Jul 2015
BACKGROUND: Studies indicate that human leukocyte antigen (HLA) gene polymorphisms are implicated in the risk of pulmonary tuberculosis (PTB).
Genetic polymorphisms of CCL1 rs2072069 G/A and TLR2 rs3804099 T/C in pulmonary or meningeal tuberculosis patients.
He et al., Shijiazhuang, China. In Int J Clin Exp Pathol, 2014
This study was to evaluate the possible association between CCL1 rs2072069 G/A or/and TLR2 rs3804099 T/C (T597C) polymorphisms and pulmonary tuberculosis (PTB) or/and tuberculous meningitis (TBM) in a sample of the Chinese adult population.
Gestational tissue transcriptomics in term and preterm human pregnancies: a systematic review and meta-analysis.
Review
Rokas et al., Nashville, United States. In Bmc Med Genomics, 2014
BACKGROUND: Preterm birth (PTB), or birth before 37 weeks of gestation, is the leading cause of newborn death worldwide.
Insights into genetic susceptibility in the etiology of spontaneous preterm birth.
Review
Smith et al., Atlanta, United States. In Appl Clin Genet, 2014
Preterm birth (PTB; <37 weeks of gestation) is a complex disorder, whose etiology is influenced by a variety of factors.
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
GeneRIF
Yoshida et al., Tokyo, Japan. In Cereb Cortex, 2013
PTB depletion in the dorsal telencephalon is causally involved in the development of hydrocephalus. And PTB is important for the maintenance of Adherens Junctions in the neural stem cells of the dorsal telencephalon.
Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
Impact
Pawson et al., Toronto, Canada. In Nature, 2013
Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 that contain phosphotyrosine (pTyr)-binding (PTB) domains.
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Impact
Fu et al., Wuhan, China. In Cell, 2013
Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Impact
Burge et al., Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Impact
Lu et al., Houston, United States. In Nat Cell Biol, 2012
Nuclear PKM2 acts as a coactivator of β-catenin to induce c-Myc expression, resulting in the upregulation of GLUT1, LDHA and, in a positive feedback loop, PTB-dependent PKM2 expression.
Stem cell factor receptor/c-Kit: from basic science to clinical implications.
Review
Impact
Rönnstrand et al., Uppsala, Sweden. In Physiol Rev, 2012
Signaling proteins are recruited to activated c-Kit by certain interaction domains (e.g., SH2 and PTB) that specifically bind to phosphorylated tyrosine residues in the intracellular region of c-Kit.
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
GeneRIF
Holmberg et al., Umeå, Sweden. In Hum Mutat, 2012
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
GeneRIF
Black et al., Los Angeles, United States. In Nat Neurosci, 2012
The polypyrimidine tract binding proteins PTBP1 and PTBP2 repressed Psd-95 (also known as Dlg4) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.
GeneRIF
Hutvagner et al., Dundee, United Kingdom. In Plos One, 2011
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.
Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.
GeneRIF
Yoshida et al., Tokyo, Japan. In Cell Cycle, 2011
PTB regulates the precise expression of CDK11(p58) through direct interaction with CDK11(p58) IRES and promotes M phase progression in ES cells.
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