Regulation of the expression and activity of Unr in mammalian cells.
Coventry, United Kingdom. In Biochem Soc Trans, Jan 2016
Translation of at least some unr transcripts can occur by internal initiation and is regulated in a cell-cycle-dependent manner; binding of PTB (polypyrimidine tract-binding protein) and Unr to the 5'-UTR inhibits translation, but these are displaced by heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNPC1/C2) during mitosis to stimulate translation.
A critical role of interleukin-1 in preterm labor.
Montréal, Canada. In Cytokine Growth Factor Rev, Dec 2015
UNASSIGNED: Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.