Extra-pulmonary tuberculosis: a biomarker analysis.
Madrid, Spain. In Infection, Aug 2014
INTRODUCTION: Studies on biomarkers in tuberculosis are focused on pulmonary forms of this disease (PTB), and only limited information is currently available on biomarkers of extra-pulmonary tuberculosis (EPTB).
Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling.
Stony Brook, United States. In Exp Hematol, Jun 2014
Using a Src homology 2/phosphotyrosine-binding (SH2/PTB) domain binding microarray, we identified novel c-Mpl binding partners for phosphorylated Y591, including Src homology region 2 domain-containing phosphatase-1 (SHP-1), spleen tyrosine kinase (SYK) and Bruton's tyrosine kinase (BTK).
The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.
New York City, United States. In Cold Spring Harb Perspect Biol, Mar 2013
As in prototypical RTKs, tyrosine phosphorylation in the juxtamembrane region of InsR creates recruitment sites for downstream signaling proteins (IRS [InsR substrate] proteins, Shc) containing a phosphotyrosine-binding (PTB) domain, and tyrosine phosphorylation in the kinase activation loop stimulates InsR's catalytic activity.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.
Defining the roles and interactions of PTB.
Cambridge, United Kingdom. In Biochem Soc Trans, 2012
PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains.