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Polypyrimidine tract binding protein 1

PTB, Heterogeneous-Nuclear Ribonucleoprotein, Polypyrimidine Tract-Binding Protein
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, AGE
Papers using PTB antibodies
Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells.
Supplier
Ryu Wang-Shick, In PLoS ONE, 2005
... Antisera for western blot to hnRNP I (PTB) was purchased from Santa Cruz Biotechnology, mouse monoclonal antibodies to ...
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
Supplier
Tarn Woan-Yuh et al., In The Journal of Cell Biology, 2003
... The His-tagged PTB expression vector was constructed by cloning the human PTB-coding region into pET-32a (QIAGEN).
Papers on PTB
Interleukin 7 Upregulates CD95 on CD4+ T Cells by Affecting mRNA Alternative Splicing: Priming for a Synergistic Effect on HIV-1 Reservoir Maintenance.
New
Zhang et al., Xinhui, China. In J Biol Chem, 19 Dec 2014
Here, we observed that, through increasing microRNA-124 (miR-124), IL-7 downregulates the splicing regulator polypyrimidine tract binding protein (PTB), leading to inclusion of the transmembrane domain-encoding exon 6 of CD95 mRNA and subsequently, elevation of CD95 on memory CD4+ T cells.
Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5' splice site choice.
New
Makeyev et al., Singapore, Singapore. In Plos Genet, 30 Nov 2014
Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5' and 3' splice site (5'ss and 3'ss) usage in a large set of mammalian transcripts.
Intestinal Microbiota is Different in Women with Preterm Birth: Results from Terminal Restriction Fragment Length Polymorphism Analysis.
New
Saito et al., Toyama, Japan. In Plos One, Dec 2013
Using terminal restriction fragment length polymorphism (T-RFLP), we compared the levels of operational taxonomic units of both intestinal and vaginal flora among three groups: pregnant women who delivered term babies without preterm labor (non-PTL group) (n = 20), those who had preterm labor but delivered term babies (PTL group) (n = 11), and those who had preterm birth (PTB group) (n = 10).
A derived network-based interferon-related signature of human macrophages responding to Mycobacterium tuberculosis.
New
Fan et al., Shanghai, China. In Biomed Res Int, Dec 2013
TMtb-iNet correlated as strongly as THP1r2Mtb-induced signature on a public transcriptional dataset of patients with pulmonary tuberculosis (PTB).
Maternal nutrition interventions to improve maternal, newborn, and child health outcomes.
Review
New
Martorell et al., Atlanta, United States. In Nestle Nutr Inst Workshop Ser, Dec 2013
Maternal undernutrition affects a large proportion of women in many developing countries, but has received little attention as an important determinant of poor maternal, newborn, and child health (MNCH) outcomes such as intrauterine growth restriction, preterm birth (PTB), and maternal and infant morbidity and mortality.
Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.
Review
New
Pawson et al., Toronto, Canada. In Cold Spring Harb Perspect Biol, Dec 2013
Signaling effectors are recruited to these phosphotyrosine (pTyr) sites primarily through Src homology 2 (SH2) domains and pTyr-binding (PTB) domains.
Preterm birth and its long-term effects: methylation to mechanisms.
Review
New
Smith et al., Atlanta, United States. In Biology (basel), Dec 2013
This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.
PTB Binds to the 3' Untranslated Region of the Human Astrovirus Type 8: A Possible Role in Viral Replication.
New
De Nova-Ocampo et al., Mexico. In Plos One, Dec 2013
The 3' untranslated region (3'UTR) of human astroviruses (HAstV) consists of two hairpin structures (helix I and II) joined by a linker harboring a conserved PTB/hnRNP1 binding site.
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
New
GeneRIF
Yoshida et al., Tokyo, Japan. In Cereb Cortex, Aug 2013
PTB depletion in the dorsal telencephalon is causally involved in the development of hydrocephalus. And PTB is important for the maintenance of Adherens Junctions in the neural stem cells of the dorsal telencephalon.
Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
New
Impact
Pawson et al., Toronto, Canada. In Nature, Aug 2013
Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 that contain phosphotyrosine (pTyr)-binding (PTB) domains.
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
New
Impact
Fu et al., Wuhan, China. In Cell, Feb 2013
Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Impact
Burge et al., Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.
The uterine myocyte as a target for prevention of preterm birth.
Review
Slater et al., Edmonton, Canada. In Facts Views Vis Obgyn, 2012
Preterm birth (PTB) remains the most common cause of neonatal morbidity and mortality as well as long-term disability.
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Impact
Lu et al., Houston, United States. In Nat Cell Biol, 2012
Nuclear PKM2 acts as a coactivator of β-catenin to induce c-Myc expression, resulting in the upregulation of GLUT1, LDHA and, in a positive feedback loop, PTB-dependent PKM2 expression.
Stem cell factor receptor/c-Kit: from basic science to clinical implications.
Review
Impact
Rönnstrand et al., Uppsala, Sweden. In Physiol Rev, 2012
Signaling proteins are recruited to activated c-Kit by certain interaction domains (e.g., SH2 and PTB) that specifically bind to phosphorylated tyrosine residues in the intracellular region of c-Kit.
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
GeneRIF
Holmberg et al., Umeå, Sweden. In Hum Mutat, 2012
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
GeneRIF
Black et al., Los Angeles, United States. In Nat Neurosci, 2012
The polypyrimidine tract binding proteins PTBP1 and PTBP2 repressed Psd-95 (also known as Dlg4) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.
GeneRIF
Hutvagner et al., Dundee, United Kingdom. In Plos One, 2011
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.
Preterm Cervical Ripening in humans.
Review
Dubicke et al., Stockholm, Sweden. In Facts Views Vis Obgyn, 2011
Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity.
Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.
GeneRIF
Yoshida et al., Tokyo, Japan. In Cell Cycle, 2011
PTB regulates the precise expression of CDK11(p58) through direct interaction with CDK11(p58) IRES and promotes M phase progression in ES cells.
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