RBM24 Is a Major Regulator of Muscle-Specific Alternative Splicing.
Bad Nauheim, Germany. In Dev Cell, 13 Nov 2014
Furthermore, we demonstrate that binding of RBM24 to an intronic splicing enhancer (ISE) is essential and sufficient to overcome repression of exon inclusion by an exonic splicing silencer (ESS) containing PTB and hnRNP A1/A2 binding sites.
Maternal nutrition interventions to improve maternal, newborn, and child health outcomes.
Atlanta, United States. In Nestle Nutr Inst Workshop Ser, Dec 2013
Maternal undernutrition affects a large proportion of women in many developing countries, but has received little attention as an important determinant of poor maternal, newborn, and child health (MNCH) outcomes such as intrauterine growth restriction, preterm birth (PTB), and maternal and infant morbidity and mortality.
Preterm birth and its long-term effects: methylation to mechanisms.
Atlanta, United States. In Biology (basel), Dec 2013
This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.