Dietary modulation of the microbiome affects autoinflammatory disease.
Memphis, United States. In Nature, 2015
Pstpip2(cmo) mice, which express a homozygous Leu98Pro missense mutation in the Pombe Cdc15 homology family protein PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2), spontaneously develop osteomyelitis that resembles chronic recurrent multifocal osteomyelitis in humans.
Autoinflammatory bone disorders.
Iowa City, United States. In Curr Opin Rheumatol, 2007
The genes responsible for Majeed syndrome (LPIN2), murine chronic multifocal osteomyelitis (pstpip2), and cherubism (SH3BP2 and possibly PTPN11) have been identified.