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Proline-serine-threonine phosphatase interacting protein 1

PSTPIP1, Papas, CD2BP1, def2, PSTPIP
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, SET, ACID, Gli3, OUT
Papers on PSTPIP1
Theoretical modeling of the L2,3-edge X-ray absorption spectra of Mn(acac)2 and Co(acac)2 complexes.
Casarin et al., Padova, Italy. In Phys Chem Chem Phys, Feb 2016
In addition to the agreement between experiment and theory, the combined use of the B3LYP exchange-correlation functional and the def2-TZVP(-f) basis set provided useful information about the coordinative geometry around the M(ii) ions as well as about the nature and the strength of the Mn-O and Co-O interaction.
1,1,2,2-Tetracyanocyclopropane (TCCP) as supramolecular synthon.
Mooibroek et al., Palma, Spain. In Phys Chem Chem Phys, Feb 2016
Complexes of TCCP with common small molecules, anions, aromatics like fullerenes, amino acids and nucleobases were computed at the DFT BP86-D3/def2-TZVP level of theory.
Modeling the Detection of Organic and Inorganic Compounds using Iodide-Based Chemical Ionization.
Kurtén et al., In J Phys Chem A, Feb 2016
Systematic configurational sampling of the free molecules and clusters was carried out at the B3LYP/6-31G* level, followed by subsequent calculations at the PBE/SDD and CCSD(T)/def2-QZVPP//PBE/aug-cc- pVTZ-PP levels.
The stacking interactions of bipyridine complexes: the influence of the metal ion type on the strength of interactions.
Zarić et al., Doha, Qatar. In J Mol Model, Jan 2016
The strength of the stacking interactions in the bipy complexes of nickel, palladium, and platinum, [M(CN)2 bipy]2 (M = Ni, Pd, Pt), was calculated using the ωB97xD/def2-TZVP method.
PSTPIP1 Gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) Syndrome.
Cañueto et al., Salamanca, Spain. In Br J Dermatol, Jan 2016
(2) PSTPIP1 gene mutations affecting proteins of the inflammasome complex or proteins that regulate it's function, responsible for the inflammatory pathway, are associated with AIDs.
Matrix-isolation and ab initio study of HKrCCCl and HXeCCCl.
Khriachtchev et al., Helsinki, Finland. In J Chem Phys, Jan 2016
The assignments of the new noble-gas molecules are supported by deuteration experiments and quantum chemical calculations at the MP2(full) and CCSD(T) levels of theory with the def2-TZVPPD basis set.
Successful treatment of PASH syndrome with infliximab, cyclosporine and dapsone.
Leverkus et al., Heidelberg, Germany. In J Eur Acad Dermatol Venereol, Nov 2015
We performed genetic analysis for PSTPIP1 mutations associated with PAPA syndrome.
Monogenic autoinflammatory diseases: Cytokinopathies.
Masters et al., Australia. In Cytokine, Aug 2015
These include syndromes where the production of IL-1 is increased by mutation of innate immune sensors such as NLRP3, upstream signalling molecules such as PSTPIP1 and receptors or downstream signalling molecules, such as IL-1Ra.
CT and MRI of congenital nasal lesions in syndromic conditions.
Robson et al., Chicago, United States. In Pediatr Radiol, Jul 2015
Congenital malformations of the nose can be associated with a variety of syndromes, including solitary median maxillary central incisor syndrome, CHARGE syndrome, Bosma syndrome, median cleft face syndrome, PHACES association, Bartsocas-Papas syndrome, Binder syndrome, duplication of the pituitary gland-plus syndrome and syndromic craniosynsotosis (e.g., Apert and Crouzon syndromes) among other craniofacial syndromes.
Pyoderma gangrenosum: pathogenetic oriented treatment approaches.
Tchernev et al., Dresden, Germany. In Wien Med Wochenschr, 2014
Mutations in the PSTPIP1 gene have been identified in patients with pyogenic arthritis, pyoderma gangrenosum and acne syndrome.
Crystal structure determination of the nonclassical 2-norbornyl cation.
Krossing et al., Freiburg, Germany. In Science, 2013
All three structures agree very well with quantum chemical calculations at the MP2(FC)/def2-QZVPP level of theory.
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
Dixit et al., San Francisco, United States. In Science, 2013
Receptor-interacting protein kinase 4 (RIPK4) is required for epidermal differentiation and is mutated in Bartsocas-Papas syndrome.
Rare hereditary autoinflammatory disorders: towards an understanding of critical in vivo inflammatory pathways.
Kanazawa, Wakayama, Japan. In J Dermatol Sci, 2012
Inflammasomopathies are diseases with dysregulated NLRP3 inflammasome activation, and include CAPS with NLRP3, FMF with MEFV, and PAPAS with PSTPIP1 mutations.
Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum.
Glant et al., Chicago, United States. In Clin Exp Dermatol, 2011
novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum
Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene.
Koltun et al., In Inflamm Bowel Dis, 2011
non-mutated gene and pyoderma gangrenosum in IBD unresponsive to anakinra treatment
Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients.
Creveaux et al., Clermont-Ferrand, France. In Dig Dis Sci, 2010
The CCTG repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease.
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome): report of a sporadic case without an identifiable mutation in the CD2BP1 gene.
Chiu et al., In J Am Acad Dermatol, 2009
PAPA syndrome occurs without identifiable mutation in CD2BB1
Pyrin Modulates the Intracellular Distribution of PSTPIP1.
Gumucio et al., Ann Arbor, United States. In Plos One, 2008
demonstrate that pyrin can recruit PSTPIP1 into aggregations (specks) of ASC, another pyrin binding protein. ASC specks are associated with inflammasome activity
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse.
Siminovitch et al., Toronto, Canada. In Immunity, 2003
PSTPIP1 acts downstream of CD2/CD2AP to link CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation.
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