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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphatidylserine synthase 1

PSS-1, PSORS2, phosphatidylserine synthase-1, PSSI
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS1, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001 [PubMed 11084049]).[supplied by OMIM, May 2009] (from NCBI)
Top mentioned proteins: DAN, HAD, MEN, OUT, AGE
Papers on PSS-1
A randomized clinical trial of group cognitive processing therapy compared with group present-centered therapy for PTSD among active duty military personnel.
New
Peterson et al., Boston, United States. In J Consult Clin Psychol, Dec 2015
The Posttraumatic Stress Symptom Interview (PSS-1) was a secondary measure.
Is Pelvic Floor Muscle Training Effective for Men With Poststroke Lower Urinary Tract Symptoms? A Single-Blinded Randomized, Controlled Trial.
New
Jensen et al., Lund, Sweden. In Am J Mens Health, Nov 2015
The effect was evaluated by the DAN-PSS-1 (Danish Prostate Symptom Score) questionnaire, a voiding diary, and digital anal palpation of the pelvic floor muscle.
Lenz-Majewski hyperostotic dwarfism with hyperphosphoserinuria from a novel mutation in PTDSS1 encoding phosphatidylserine synthase 1.
New
Mumm et al., Saint Louis, United States. In J Bone Miner Res, Apr 2015
In 2014, a publication concerning five unrelated patients with LMHD disclosed that all carried one of three heterozygous missense mutations in PTDSS1 encoding phosphatidylserine synthase 1 (PSS1).
Clinical characteristics of pruritus in patients with scalp psoriasis and their relation with intraepidermal nerve fiber density.
Kim et al., Pusan, South Korea. In Ann Dermatol, 2014
OBJECTIVE: To determine the correlation among the clinical characteristics of pruritus, psoriasis scalp severity index (PSSI), and intraepidermal nerve fiber (IENF) density in psoriatic scalp lesions.
Network connectivity modulates power spectrum scale invariance.
Mujica-Parodi et al., Boulder, United States. In Neuroimage, 2014
Measures of complexity are sensitive in detecting disease, which has made them attractive candidates for diagnostic biomarkers; one complexity measure that has shown promise in fMRI is power spectrum scale invariance (PSSI).
Outcomes of medical and surgical treatment for lower urinary tract symptoms (benign prostatic obstruction)--a population-based cohort study.
Tammela et al., Tampere, Finland. In Int J Clin Pract, 2014
LUTS were evaluated using DAN-PSS-1 questionnaire.
Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome.
Impact
Moore et al., London, United Kingdom. In Nat Genet, 2014
By using whole-exome sequencing and selecting variants consistent with the predicted dominant de novo etiology of LMS, we identified causative heterozygous missense mutations in PTDSS1, which encodes phosphatidylserine synthase 1 (PSS1).
Phosphatidylserine metabolism modification precedes manganese-induced apoptosis and phosphatidylserine exposure in PC12 cells.
Buratta et al., Perugia, Italy. In Neurotoxicology, 2013
Evaluating the expression of two isoforms of PS-synthesizing enzyme (PSS), PSSII was increased both in cell lysate and TM, while PSSI was unchanged.
CARD14 expression in dermal endothelial cells in psoriasis.
Lowes et al., Bethesda, United States. In Plos One, 2013
Mutations in the caspase recruitment domain, family member 14 (CARD14) gene have recently been described in psoriasis patients, and explain the psoriasis susceptibility locus 2 (PSORS2).
Cellular and humoral immune responses against the Plasmodium vivax MSP-1₁₉ malaria vaccine candidate in individuals living in an endemic area in north-eastern Amazon region of Brazil.
Ferreira-da-Cruz et al., Rio de Janeiro, Brazil. In Malar J, 2012
Peripheral blood mononuclear cells were isolated and the cellular proliferation and activation was analysed in presence of 19 kDa fragment of MSP-1 (PvMSP-1₁₉) and Plasmodium falciparum PSS1 crude antigen.
N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells.
GeneRIF
Vance et al., Edmonton, Canada. In J Biol Chem, 2011
Site-directed mutagenesis of binding sites within the Pss1 promoter demonstrated that Sp and N-Myc synergistically activate Pss1 expression in astrocytes
Purification and characterization of human phosphatidylserine synthases 1 and 2.
GeneRIF
Kuge et al., Fukuoka, Japan. In Biochem J, 2009
Purification and characterization of human phosphatidylserine synthases 1 and 2.
Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice.
GeneRIF
Vance et al., Edmonton, Canada. In J Biol Chem, 2008
elimination of either PSS1 or PSS2, but not both, is compatible with mouse viability
Synthesis of phosphatidylserine by base exchange in Triton-insoluble floating fractions from rat cerebellum.
GeneRIF
Mozzi et al., Perugia, Italy. In J Neurochem, 2007
SBEE, synthesizing PS in the binding area for PKC, participates inn signal transduction. The capability of SBEE to utilize not only serine but also ethanolamine, as free exchanging base, suggests a mechanism for modulating in loco PS concentration.
Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein.
Impact
Birk et al., Beersheba, Israel. In Nat Genet, 2006
We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein.
PSORS2 markers are not associated with psoriatic arthritis in the Italian population.
GeneRIF
Novelli et al., Roma, Italy. In Hum Hered, 2005
PSORS2 alleles are not susceptibility factors in arthritis psoriatic patients of Italian origin
Phospholipid biosynthesis in mammalian cells.
Review
Vance et al., Edmonton, Canada. In Biochem Cell Biol, 2004
Finally, the two base-exchange enzymes, phosphatidylserine synthase-1 and phosphatidylserine synthase-2, that synthesize phosphatidylserine in mammalian cells are also discussed.
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis.
Impact
Bowcock et al., Saint Louis, United States. In Nat Genet, 2003
Psoriasis is associated with HLA class I alleles, and previous linkage analysis by our group identified a second psoriasis locus at 17q24-q25 (PSORS2; ref. 7).
Genetics of psoriasis: the potential impact on new therapies.
Review
Barker et al., Saint Louis, United States. In J Am Acad Dermatol, 2003
A number of genetic loci have been identified by genome wide linkage scans and two loci have been replicated: PSORS1 on chromosome 6, within the major histocompatibility complex, and PSORS2 on chromosome 17q.
Involvement of Rhizobium leguminosarum nodulation genes in gene expression in pea root hairs.
Bisseling et al., Wageningen, Netherlands. In Plant Mol Biol, 1989
Using R. leguminosarum mutants it was shown that the nodC gene is required for the induction and enhancement of expression of the RH-42 and RH-44 genes, respectively, while the Rhizobium chromosomal gene pss1, involved in exopolysaccharide synthesis, is not essential.
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