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G protein-coupled receptor 45

PSP24, GPR45, PSP24 alpha
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, LpA-I, GPCR, S1P1, GPCR
Papers on PSP24
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Globin gene expression in correlation with G protein-related genes during erythroid differentiation.
Schechter et al., Belgrade, Serbia. In Bmc Genomics, 2012
During ontogeny, GPR45 and ARRDC1 genes have the most prominent expression in FL-derived erythroid progenitor cells, GNL3 and GRP65 genes in CB-derived cells (high gamma-globin gene expression), GPR110 and GNG10 in BM-derived cells, GPR89C and GPR172A in PB-derived cells, and GPR44 and GNAQ genes in mPB-derived cells (high beta-globin gene expression).
Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.
GeneRIF
Prevot et al., Saint-Pierre-des-Corps, France. In J Neurosci, 2012
Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Review
Erickson et al., Houston, United States. In Cancer Treat Res, 2001
PSP24 has been shown to be responsive to LPA in Xenopus oocytes, however, its role in mammalian cells is unclear.
Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells.
Pyne et al., Glasgow, United Kingdom. In Br J Pharmacol, 2001
The de-acylated product of PA, lysophosphatidic acid (LPA), which binds to members of the endothelial differentiation gene (EDG) family of receptors also stimulated p42/p44 MAPK in a pertussis toxin sensitive manner, but with an approximately 100 - 1000 fold lower potency compared with the different molecular species of PA.
Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells.
Chun et al., San Diego, United States. In J Biol Chem, 2001
By contrast, an unrelated GPCR, PSP24, was reported to be a high affinity LPA receptor in Xenopus laevis oocytes, raising the possibility that Xenopus uses a very different form of LPA signaling.
Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading.
Saulnier-Blache et al., Toulouse, France. In J Biol Chem, 2001
EDG-2, EDG-4, EDG-7, and PSP24 genes encode distinct lysophosphatidic acid (LPA) receptors.
Identification of four novel human G protein-coupled receptors expressed in the brain.
O'Dowd et al., Toronto, Canada. In Brain Res Mol Brain Res, 2001
Sequence analysis of GPR63 and GPR77 revealed highest sequence identities in the TM regions with the oGPCR PSP24 (58%) and the anaphylatoxin C5a receptor (49%) respectively.
Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.
Shimizu et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2000
Xenopus PSP24 (xPSP24) is a G-protein-coupled receptor which was originally identified as a functional lysophosphatidic acid (LPA) receptor.
Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.
Shimizu et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2000
From mouse genomic libraries and human brain cDNA, we cloned three novel G-protein-coupled receptors (GPCRs), which have about 55-70% homologies with Xenopus PSP24 (xPSP24).
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Review
Mills et al., Houston, United States. In Ann N Y Acad Sci, 2000
PSP24 and members of the endothelial differentiation gene (EDG) family (EDG1, EDG2, EDG4, and EDG7) of G protein-coupled receptors mediate LPA signaling.
Pharmacological characterization of phospholipid growth-factor receptors.
Review
Parrill et al., Memphis, United States. In Ann N Y Acad Sci, 2000
Northern blot and RT-PCR results reinforce the coexpression of PSP24 alpha and different members of the EDG1-7 receptors in the same cell.
Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.
Berliner et al., Los Angeles, United States. In Lab Invest, 1999
We demonstrate that at least five potential LPA receptors are expressed by HAEC: Edg-1, -3, -4, and -5 as well as PSP24.
A 24 kDa parasitism-specific protein from the Caribbean fruit fly, Anastrepha suspensa: cDNA and deduced amino acid sequence.
Lawrence et al., Gainesville, United States. In Insect Biochem Mol Biol, 1999
A 24 kDa parasitism-specific protein (PSP24) was previously reported from the hemolymph of the Caribbean fruit fly, Anastrepha suspensa (Diptera: Tephritidae) after parasitization by the wasp Diachasmimorpha longicaudata (Hymenoptera: Braconidae).
Discovery of three novel orphan G-protein-coupled receptors.
O'dowd et al., Toronto, Canada. In Genomics, 1999
We have discovered three novel human genes, GPR34, GPR44, and GPR45, encoding family A G-protein-coupled receptors (GPCRs).
Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes.
Tigyi et al., Memphis, United States. In Mol Pharmacol, 1998
We provide evidence that the PSP24 receptor is selective for LPA and not activated by the other two PLGFs.
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