γ-Secretase inhibitors and modulators.
Gainesville, United States. In Biochim Biophys Acta, 2013
γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is now being considered as a therapeutic target for a number of diseases.
(Make) stick and cut loose--disintegrin metalloproteases in development and disease.
Leuven, Belgium. In Birth Defects Res C Embryo Today, 2006
A common denominator of ADAM-mediated proteolysis is the ectodomain shedding of a broad spectrum of substrates, including paracrine growth factors like epidermal growth factor receptor (EGFR) ligands, cell adhesion molecules like CD44 or cadherins, and the initiation of regulated intramembrane proteolysis (RIP), whereby the transmembrane fragment of the respective substrate is further cleaved by an intramembrane cleaving protease to release an intracellular domain acting as a nuclear transcription regulator.
The pea lectin gene family contains only one functional gene.
Paris, France. In Plant Mol Biol, 1987
Four positive recombinant phages, λI 101, λI 52, λIII 51 and λIV 22, were isolated and the DNA sequences of the subclones, designated respectively PSL1, PSL2, PSL3 and PSL4, were determined.