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Pregnancy specific beta-1-glycoprotein 3

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] (from NCBI)
Top mentioned proteins: PSG, CD45, ACID, PSG11, CEA
Papers on PSG3
A novel regulator of human villous trophoblast fusion: the Krüppel-like factor 6.
Panzetta-Dutari et al., Córdoba, Argentina. In Mol Hum Reprod, Apr 2015
Interestingly, the expression of two trophoblast biochemical differentiation markers, βhCG and PSG3, were not reduced after KLF6 silencing in differentiating trophoblast cells.
Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome.
Masuzaki et al., Nagasaki, Japan. In Prenat Diagn, 2014
RESULTS: From 50 PP mRNAs, nine [human placental lactogen (hPL); pregnancy-specific glycoproteins 2 (PSG2); human pregnancy-specific glycoproteins 3 (PSG3); syncytin; syncytin 2; retinoic acid-induced 14; A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12); chorionic glycoprotein hormones, alpha polypeptide; and chorionic glycoprotein hormones, and beta polypeptide] were selected as target mRNAs.
Occurrence of rapid eye movement sleep deprivation after surgery under regional anesthesia.
Steinfeldt et al., Mainz, Germany. In Anesth Analg, 2013
METHODS: Ambulatory polysomnography (PSG) was performed on 3 nights: the night before surgery (PSG1), the first night after surgery (PSG2), and the fifth postoperative night (PSG3).
A convenient expiratory positive airway pressure nasal device for the treatment of sleep apnea in patients non-adherent with continuous positive airway pressure.
Schweitzer et al., Chesterfield, United States. In Sleep Med, 2011
Patients meeting prespecified efficacy criteria underwent PSG3 after about 5 weeks of EPAP treatment.
Krüppel-like factor 6 expression changes during trophoblast syncytialization and transactivates ßhCG and PSG placental genes.
Panzetta-Dutari et al., Córdoba, Argentina. In Plos One, 2010
Moreover, KLF6 transactivated βhCG5, PSG5 and PSG3 gene promoters.
Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells.
Panzetta-Dutari et al., Córdoba, Argentina. In Placenta, 2010
Among them, PSG1, PSG3 and PSG5 genes achieve high mRNA levels while PSG7 and PSG9 are poorly expressed.
Effect of maternal tobacco smoke exposure on the placental transcriptome.
Brdicka et al., Praha, Czech Republic. In Placenta, 2010
Abundant levels of transcripts were found for genes encoding placental hormones (CSH1, CSHL1), pregnancy-specific proteins (PSG3, PSG4, PAPPA), and hemoglobins (HBB, HBG, HBA).
Differential display RT-PCR analysis of human choriocarcinoma cell lines and normal term trophoblast cells: identification of new genes expressed in placenta.
Castrillo et al., Madrid, Spain. In Placenta, 2004
The other 17 sequences showed high similarity to known human genes (like PSG3, FN1, PAI-2).
Effect of pregnancy-specific beta 1-glycoprotein on the development of preimplantation embryo.
Chan et al., Washington, D.C., United States. In Proc Soc Exp Biol Med, 1999
cDNA encoding two members of the PSG family, namely PSG1 and PSG3, were expressed in Chinese Hamster Ovary (CHO) cells with the expression vector pH beta APr-1-neo.
Specific cross-reaction of IgG anti-phospholipid antibody with platelet glycoprotein IIIa.
Inoue et al., Tokyo, Japan. In Thromb Haemost, 1996
We identified an IgG anti-PL mAb, designated PSG3, which cross-reacted specifically with glycoprotein (GP) IIIa in human platelets and inhibited platelet aggregation.
Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region.
Hammarström et al., Livermore, United States. In Genomics, 1994
Detailed restriction mapping and hybridization with gene-specific probes indicated that the order of the 11 Previously identified PSG genes is cen-PSG3-PSG8-PSG12-PSG1-PSG6-PSG7-+ ++PSG13-PSG2-PSG5-PSG4-PSG11-tel.
Subtle differences in human pregnancy-specific glycoprotein gene promoters allow for differential expression.
Chou et al., Bethesda, United States. In J Biol Chem, 1994
We now show that PSG1-I and PSG3 are also members of class 1 genes.
Distinction of highly homologous pregnancy-specific glycoprotein (PSG) isoforms by differential absorption of antisera with recombinant PSG fusion protein domains.
Neumaier et al., Hamburg, Germany. In J Immunol Methods, 1994
The N-terminal domain of PSG1 (PSG1-N) and PSG3 (PSG3-N) were chosen since PSG3-N, but not PSG1-N, contains an RGD sequence.
Effective induction of anti-phospholipid and anticoagulant antibodies in normal mouse.
Inoue et al., Japan. In Thromb Res, 1991
One mAb of the IgG2b subclass, named PSG3, which had been produced 10 days after the immunization, was shown to have a strong lupus anticoagulant, dsDNA binding, and HUVEC binding activities.
Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.
Hammarström et al., Umeå, Sweden. In Biochem Biophys Res Commun, 1990
SG5 is identical to PSG3, and SG9 to PSG1d, while SG8 most probably corresponds to PSG2.
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