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GINS complex subunit 1

Psf1, GINS1, CDC101
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: Psf2, CAN, HAD, POLYMERASE, MHC
Papers on Psf1
Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors.
Takakura et al., Suita, Japan. In Exp Cell Res, Jul 2015
Previously, we found that haploinsufficiency of PSF1, a DNA replication factor, led to attenuation of the bone marrow (BM) HSC pool size and lack of acute proliferation after 5-FU ablation.
Knockdown of PSF1 expression inhibits cell proliferation in lung cancer cells in vitro.
Liu et al., Xi'an, China. In Tumour Biol, Mar 2015
Partner of sld five 1 (PSF1) is a member of the heterotetrameric complex termed GINS.
Evaluation of PSF1 as a prognostic biomarker for prostate cancer.
Takakura et al., Suita, Japan. In Prostate Cancer Prostatic Dis, Mar 2015
BACKGROUND: Partner of SLD5 1 (PSF1) is an evolutionarily conserved DNA replication factor.
Overexpression of PSF1 is correlated with poor prognosis in hepatocellular carcinoma patients.
Xu et al., Xi'an, China. In Int J Biol Markers, 2015
BACKGROUND: PSF1 is a subunit of the GINS complex which is essential for establishment of DNA replication forks, and the progression of the replisome.
Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast.
Fijalkowska et al., Warsaw, Poland. In Mol Microbiol, 2014
One of such component is the GINS complex (comprising the Psf1, Psf2, Psf3 and Sld5 subunits), which participates in both initiation and elongation of DNA replication.
DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells.
Takakura et al., Suita, Japan. In Plos One, 2013
SLD5 is a member of the GINS complex composed of PSF1, PSF2, PSF3 and SLD5, playing a critical role in the formation of the DNA replication fork with CDC45 in yeast.
Partner of Sld five 3: a potential prognostic biomarker for colorectal cancer.
Wang et al., Yantai, China. In Diagn Pathol, 2013
BACKGROUND: Partner of Sld five 3 (PSF3) is a member of the evolutionarily conserved heterotetrameric complex "Go-Ichi-Ni-San" (GINS), which consists of SLD5, PSF1, PSF2, and PSF3.
Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects.
Bird et al., Seattle, United States. In Hum Mutat, 2013
Targeted comparative genomic hybridization detected a 59-kb deletion that encompasses exon 1 of ABHD12 and exons 1-4 of an adjacent gene, GINS1, and includes the promoters of both genes.
Possible role of mural cell-covered mature blood vessels in inducing drug resistance in cancer-initiating cells.
Takakura et al., Ōsaka, Japan. In Am J Pathol, 2013
We analyzed whether CICs acquire drug resistance after cancer drug treatment in a tumor cell allograft model in which we could identify and isolate living CICs by detecting a higher level of transcriptional activity of the PSF1 gene promoter.
Gene expression signatures of angiocidin and darapladib treatment connect to therapy options in cervical cancer.
Wiese et al., Bonn, Germany. In J Cancer Res Clin Oncol, 2013
Seven of these probes are induced in all cervical cancer stages: they are GINS1, PAK2, DTL, AURKA, PRKDC, NEK2 and CEP55.
[Expression of PSF1 in colon cancer tissues and its effect on the proliferation of colon cancer cells].
Wei et al., Guangzhou, China. In Zhonghua Wei Chang Wai Ke Za Zhi, 2013
OBJECTIVE: To detect the expression of PSF1 (partner of Sld five 1) in colon cancer specimens, and to explore the effect of RNA interference targeting PSF1 on the proliferation of colon cancer cells and its mechanism.
Requirement of SLD5 for early embryogenesis.
Takakura et al., Suita, Japan. In Plos One, 2012
SLD5 forms a GINS complex with PSF1, PSF2 and PSF3, which is essential for the initiation of DNA replication in lower eukaryotes.
[Expression and clinical significance of GINS complex in colorectal cancer].
Zhang et al., Guangzhou, China. In Zhonghua Wei Chang Wai Ke Za Zhi, 2011
METHODS: The expression level of GINS complex including PSF1, PSF2, PSF3 and SLD5 in CRC specimens (n=76) were detected by real-time fluorescent quantitative polymerase chain reaction.
GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding.
Kaplan et al., Nashville, United States. In J Biol Chem, 2011
GINS (Psf1, Psf2, Psf3, and Sld5) and Sld3 compete with one another for Mcm2-7 and Cdc45 binding
Up-regulation of PSF1 promotes the growth of breast cancer cells.
Ohta et al., Tokyo, Japan. In Genes Cells, 2010
These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth.
PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.
Takakura et al., Ōsaka, Japan. In Cancer Res, 2010
Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target.
Structure of the human GINS complex and its assembly and functional interface in replication initiation.
Hanaoka et al., Wako, Japan. In Nat Struct Mol Biol, 2007
the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity
A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.
Yoshida et al., Kawasaki, Japan. In Genomics Proteomics Bioinformatics, 2006
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1
Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.
Townsend et al., London, United Kingdom. In Nature, 1992
which lacks the RING4/PSF1 protein.
Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer.
DeMars et al., Boston, United States. In Nature, 1992
This pathway may depend on a transporter (PSF1) to mediate entry of the cytosolic peptides into a pre-Golgi compartment where they bind to class I heavy chains and promote their stable assembly with beta 2-microglobulin.
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