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Phosphatidic acid phosphatase type 2 domain containing 2

PSDP, PPAPDC2, Presqualene Diphosphate
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Top mentioned proteins: CAN, PIPP, iMpact, ACID, V1a
Papers on PSDP
Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes.
New
Kocarek et al., Wayne, United States. In Drug Metab Dispos, Jan 2016
The lipid phosphatase, phosphatidic acid phosphatase domain containing 2 (PPAPDC2), was recently reported to catalyze FPP dephosphorylation.
Putative regulatory factors associated with intramuscular fat content.
Coutinho et al., Piracicaba, Brazil. In Plos One, 2014
Candidate genes identified by PCIT include: ANKRD26, HOXC5 and PPAPDC2.
Design and synthesis of non-hydrolyzable homoisoprenoid α-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases.
Spielmann et al., Lexington, United States. In Bioorg Med Chem Lett, 2014
An efficient, diversity oriented synthesis of homoisoprenoid α-monofluorophosphonates utilizing electrophilic fluorination is presented along with their activity as inhibitors of PPAPDC2 family integral membrane lipid phosphatases.
Gene profiling of inflammatory genes in day 18 endometria from pregnant and non-pregnant mares.
Bruemmer et al., Fort Collins, United States. In Mol Reprod Dev, 2012
Quantitative, real-time RT-PCR confirmed the microarray results for three up-regulated genes homologous to TSC22D3, PPAPDC2, and KLF6, and three down-regulated genes homologous to ESR1, MARCKSL1, and EPSTI1 (P < 0.05).
Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.
Hurley et al., Bethesda, United States. In Embo J, 2011
The 1.85-Å crystal structure of interacting regions of the yeast ESCRT-0 and ESCRT-I complexes reveals that PSDP motifs of the Vps27 ESCRT-0 subunit bind to a novel electropositive N-terminal site on the UEV domain of the ESCRT-I subunit Vps23 centred on Trp16.
Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.
GeneRIF
Morris et al., Lexington, United States. In J Biol Chem, 2010
PDP1/PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate.
GeneRIF
Levy et al., Boston, United States. In Biochemistry, 2009
PDP1 can serve as a new checkpoint for polyisoprenyl phosphate remodeling during cell activation.[PDP1]
Lipid mediators as agonists for the resolution of acute lung inflammation and injury.
Review
Levy et al., Montpellier, France. In Am J Respir Cell Mol Biol, 2007
Presqualene diphosphate (PSDP) is a polyisoprenyl phosphate in human neutrophils that is rapidly converted to presqualene monophosphate (PSMP) upon cell activation.
Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury.
Levy et al., Boston, United States. In J Exp Med, 2006
Here, we establish presqualene diphosphate (PSDP) as an endogenous PIPP regulator of phosphatidylinositol 3-kinase (PI3K).
Identification and functional characterization of a presqualene diphosphate phosphatase.
GeneRIF
Levy et al., Boston, United States. In J Biol Chem, 2006
findings indicate that PPAPDC2 in human PMN is the first lipid phosphate phosphohydrolase identified for PSDP; regulation of this activity of the enzyme may have important roles for PMN activation in innate immunity
Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo.
Serhan et al., Boston, United States. In Br J Pharmacol, 2005
The IC(50) for a (Z)-isomer of endogenous presqualene diphosphate (PSDP) was 100 nM.
Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.
Piper et al., Iowa City, United States. In J Cell Biol, 2003
Vps27 also bound Vps23 directly via two PSDP motifs present within the Vps27 COOH terminus.
Polyisoprenyl phosphates: natural antiinflammatory lipid signals.
Review
Serhan et al., Boston, United States. In Cell Mol Life Sci, 2002
We recently uncovered a novel role for polyisoprenyl phosphates, in particular presqualene diphosphate (PSDP), as natural down-regulatory signals in human neutrophils that directly inhibit phospholipase D and superoxide anion generation.
A novel polyisoprenyl phosphate signaling cascade in human neutrophils.
Review
Serhan et al., Boston, United States. In Ann N Y Acad Sci, 2000
Activation of the leukotriene B4 receptor initiated a rapid (within seconds) decrement in presqualene disphosphate (PSDP), activation of PLD and production of superoxide anions.
Polyisoprenyl phosphates in intracellular signalling.
Impact
Serhan et al., Boston, United States. In Nature, 1997
Structural analysis of biologically active fractions gave four major phosphorylated lipids: most abundant was presqualene diphosphate (PSDP).
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