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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Discs, large homolog 4

PSD-95, postsynaptic density-95, postsynaptic density protein 95
a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, Synaptophysin, ACID, ZO-1
Papers using PSD-95 antibodies
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
Supplier
Ginsberg Stephen D., In PLoS ONE, 2010
... Rabbit polyclonal antibody against PSD-95 was from Synaptic Systems (Göttingen, Germany) ...
Pre and post-natal exposure to ambient level of air pollution impairs memory of rats: the role of oxidative stress.
Supplier
Finch Caleb E. et al., In Environmental Health Perspectives, 2009
... (glutamate receptor subunit 1; 1:3,000, rabbit; Abcam, Cambridge, MA), anti-GluA2 (1:2,000, rabbit; Millipore, Billerica, MA), anti-PSD95 (1:1,000, mouse; Abcam), anti-synaptophysin (1:5,000, mouse; Stressgene; ...
Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage
Supplier
Gahmberg Carl G. et al., In The Journal of Cell Biology, 2003
... The anti-L1CAM mAb, anti–MAP-2 mAb, and the anti-PSD95 mAb and pAb were obtained from Abcam.
Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors.
Supplier
Gottardi Cara, In PLoS ONE, 2000
... Postsynaptic density-95 (PSD-95) monoclonal antibody was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Supplier
Nguyen Trung P. et al., In Journal of Neuroimmune Pharmacology, 1998
... PSD95Cell Signaling ...
more suppliers
Papers on PSD-95
Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.
New
Kaddoumi et al., Monroe, United States. In Biochim Biophys Acta, Feb 2016
Moreover, rivastigmine demonstrated a P-gp expression dependent neuroprotective effect that was highest in APP(+)/mdr1(+/+)>APP(+)/mdr1(+/-)>APP(+)/mdr1(-/-) as determined by expression of synaptic markers PSD-95 and SNAP-25 using Western blot analysis.
LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.
New
Ko et al., Seoul, South Korea. In Cell Rep, Feb 2016
Here, we focus on LRRTM3, showing that two distinct LRRTM3 variants generated by alternative splicing regulate LRRTM3 interaction with PSD-95, but not its excitatory synapse-promoting activity.
Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
New
Hague et al., Seattle, United States. In Pharmacol Res, Feb 2016
At least 30 human GPCRs contain a Type I PSD-95/DLG/Zo-1 (PDZ) ligand in their distal C-terminal domain; this four amino acid motif of X-[S/T]-X-[φ] sequence facilitates interactions with PDZ domain-containing proteins.
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.
New
Ivarsson et al., Marseille, France. In Febs Lett, Jan 2016
Its closely linked postsynaptic density-95, discs large 1, zonula occludens-1 (PDZ) domains typically interact with C-terminal ligands.
A PDZ-Like Motif in the Biliary Transporter ABCB4 Interacts with the Scaffold Protein EBP50 and Regulates ABCB4 Cell Surface Expression.
New
Aït-Slimane et al., Paris, France. In Plos One, Dec 2015
The stability of several ABC transporters is regulated through their binding to PDZ (PSD95/DglA/ZO-1) domain-containing proteins.
Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1.
New
Huang et al., Wollongong, Australia. In Sci Rep, Dec 2015
PCP reduced protein and mRNA expressions of synaptophysin (24.9% and 23.2%, respectively) and PSD95 (31.5% and 21.4%, respectively), and the protein expression of p-Akt (26.7%) and p-GSK3β (35.2%).
Schizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology.
Review
New
Zukin et al., Dallas, United States. In Neuroscience, Dec 2015
Subfield-specific hippocampal molecular pathology exists in human psychosis tissue which could underlie this neuronal hyperactivity, including increased GluN2B-containing NMDA receptors in hippocampal CA3, along with increased postsynaptic density protein-95 (PSD-95) along with augmented dendritic spines on the pyramidal neuron apical dendrites.
Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 Proteins.
Review
New
Impact
Friedman et al., Pittsburgh, United States. In Pharmacol Rev, Jul 2015
Several clinically significant drug transporters possess a recognition sequence that binds to PSD-95/Drosophila discs large/ZO-1 (PDZ) proteins.
Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling.
Review
New
Ferguson et al., London, Canada. In Mol Endocrinol, Jun 2015
This review focuses on GPCR interacting PSD95-disc large-zona occludens domain containing scaffolds in the regulation of endocrine receptor signaling as well as their potential role as therapeutic targets for the treatment of endocrinopathies.
Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis.
Review
Lu et al., Wuhan, China. In Regen Med Res, 2014
Accumulated evidences show NMDA receptor downstream effectors, such as PSD-95, DAPK1, and ERK, had been revealed to be linked with neuronal damage.
RASSF6; the Putative Tumor Suppressor of the RASSF Family.
Review
Hata et al., Tokyo, Japan. In Cancers (basel), 2014
RASSF6 additionally harbors the PSD-95/Discs large/ZO-1 (PDZ)-binding motif.
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Impact
Dolmetsch et al., Stanford, United States. In Nature, 2013
IGF1 treatment promotes formation of mature excitatory synapses that lack SHANK3 but contain PSD95 and N-methyl-D-aspartate (NMDA) receptors with fast deactivation kinetics.
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.
Impact
Huber et al., Dallas, United States. In Cell, 2013
Upon MEF2 activation, PSD-95 is ubiquitinated by the ubiquitin E3 ligase murine double minute 2 (Mdm2) and then binds to Pcdh10, which links it to the proteasome for degradation.
The spatial architecture of protein function and adaptation.
Impact
Ranganathan et al., Dallas, United States. In Nature, 2012
Using a PDZ domain (PSD95(pdz3)) model system, we show that sector positions are functionally sensitive to mutation, whereas non-sector positions are more tolerant to substitution.
Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.
Impact
ENACT trial investigators et al., Calgary, Canada. In Lancet Neurol, 2012
BACKGROUND: Neuroprotection with NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95 protein, has been shown in a primate model of stroke.
Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.
GeneRIF
Alberch et al., Barcelona, Spain. In Exp Neurol, 2012
30-week-old BDNF/ mice displayed increased TrkB levels in the hippocampus but not in the motor neocortex
Therapeutic testosterone administration preserves excitatory synaptic transmission in the hippocampus during autoimmune demyelinating disease.
GeneRIF
Voskuhl et al., Los Angeles, United States. In J Neurosci, 2012
PSD-95 appears to be a neuropathological substrate to impaired synaptic transmission in the hippocampus during autoimmune demyelinating disease.
The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).
GeneRIF
Zhang et al., United States. In J Biol Chem, 2012
a role of PAR-1 in spine morphogenesis in hippocampal neurons through phosphorylating PSD-95.
Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1.
GeneRIF
Ivarsson et al., Leuven, Belgium. In Febs Lett, 2012
study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization
Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95.
GeneRIF
Stephenson et al., London, United Kingdom. In J Biol Chem, 2012
These findings provide a molecular basis for the differential association of NMDA receptor subtypes with PSD-95 MAGUK scaffold proteins.
More papers using PSD-95 antibodies
In vivo protein transduction: delivery of a biologically active protein into the mouse
Supplier
Dickenson Anthony H et al., In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 (1:1,000, ab18258; Abcam, Cambridge, UK), rabbit anti-nNOS ...
Chronic myeloid leukemia
Supplier
Combs Colin K et al., In Journal of Neuroinflammation, 1998
... Anti-PSD95 and anti-pSrc (Tyr416) antibodies were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
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