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Discs, large homolog 2

PSD-93, chapsyn-110, DLG2
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008] (from NCBI)
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Papers using PSD-93 antibodies
Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
Supplier
Uversky Vladimir N., In PLoS ONE, 1996
... mouse anti-CHK from BD BioSciences, mouse anti-Src (clone GD11) from Upstate (Lake Placid, NY), rabbit anti-PSD93 from Alomone Labs Ltd., rabbit anti-c-Src (Y215) ...
Papers on PSD-93
Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.
GeneRIF
Wollmuth et al., Stony Brook, United States. In J Comp Neurol, 2011
Membrane-associated guanylate kinase homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.
In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.
GeneRIF
Grant et al., United Kingdom. In J Neurosci, 2010
These data show critical roles for psd-93 and interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes.
Effect of PSD-95/SAP90 and/or PSD-93/chapsyn-110 deficiency on the minimum alveolar anesthetic concentration of halothane in mice.
GeneRIF
Johns et al., Baltimore, United States. In Anesthesiology, 2010
PSD-93 deficiency in knock-out mice results in a decrease in the minimum alveolar anesthetic concentration of halothane.
Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity.
GeneRIF
Xu et al., Nanjing, China. In Neuroscience, 2010
Since NMDARs, Ca(2+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders.
Structure of the first PDZ domain of human PSD-93.
GeneRIF
Gajhede et al., Copenhagen, Denmark. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition
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