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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphoserine aminotransferase 1

The protein encoded by this gene is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, phosphoserine phosphatase, HAD, Glycine Hydroxymethyltransferase
Papers on PSAT
Two new cases of serine deficiency disorders treated with l-serine.
de Lonlay et al., Paris, France. In Eur J Paediatr Neurol, Jan 2016
OBJECTIVE AND PATIENTS: We report on two new cases of serine deficiency due respectively to 3-phosphoglycerate dehydrogenase (PHGDH) deficiency (Patient 1) and phosphoserine aminotransferase (PSAT1) deficiency (Patient 2), presenting with congenital microcephaly (<3rd centile at birth) and encephalopathy with spasticity.
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Cantley et al., New York City, United States. In Nat Genet, Dec 2015
We found that NRF2 controls the expression of the key serine/glycine biosynthesis enzyme genes PHGDH, PSAT1 and SHMT2 via ATF4 to support glutathione and nucleotide production.
Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.
Kang et al., Taegu, South Korea. In Oncology, Nov 2015
Phosphoglycerate dehydrogenase (PHGDH), pyruvate dehydrogenase kinase (PDK) 1, PDK2, pyruvate kinase M2 (PKM2), and phosphoserine aminotransferase (PSAT) expression were investigated by immunohistochemical staining (IHC) in TT and pNT.
Prostate-specific antigen kinetic profiles during androgen deprivation therapy as prognostic factors in castration-resistant prostate cancer.
Kwak et al., Seoul, South Korea. In Urol Oncol, May 2015
The parameters evaluated as prognostic factors were as follows: age, body mass index, Gleason score, clinical TNM stage, prior radical prostatectomy, prior radiation therapy, performance status, presence of pain, laboratory results at the start of DCT, and prostate-specific antigen (PSA) kinetics during prior androgen deprivation therapy (ADT), including PSA level at the start of ADT (PSA-ADT), PSA half-time (PSAT1/2), time to nadir, PSA level at nadir (PSA-Nadir), duration of nadir, PSA doubling time (PSADT), and PSA level at the start of DCT (PSA-DCT).
Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3.
Guo et al., Shanghai, China. In Diabetes, May 2015
Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis.
Molecular cloning and expression of phosphoglycerate dehydrogenase and phosphoserine aminotransferase in the serine biosynthetic pathway from Acanthamoeba castellanii.
Cheng et al., Shanghai, China. In Parasitol Res, Apr 2015
This study characterised phosphoglycerate dehydrogenase (PGDH) and phosphoserine aminotransferase (PSAT) in the phosphorylated serine biosynthetic pathway of Acanthamoeba castellanii.
PSAT1 regulates cyclin D1 degradation and sustains proliferation of non-small cell lung cancer cells.
Guan et al., Guangzhou, China. In Int J Cancer, Mar 2015
Our current study found that phosphoserine aminotransferase 1 (PSAT1), an enzyme catalyzing serine biosynthesis, was significantly up-regulated in non-small cell lung cancer (NSCLC) and was involved in the regulation of E2F activity.
Electro-hyperthermia inhibits glioma tumorigenicity through the induction of E2F1-mediated apoptosis.
Lee et al., Seoul, South Korea. In Int J Hyperthermia, 2014
The transcriptomic analysis of differential gene expression under mEHT showed that the anti-proliferative effects were induced through a subset of molecular alterations, including the up-regulation of E2F1 and CPSF2 and the down-regulation of ADAR and PSAT1.
MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1.
Mao et al., Shanghai, China. In Cell Physiol Biochem, 2014
PSAT1 was identified as a direct target of miR-340 and its ectopic expression partially reversed the miR-340 mediated inhibition of viability, invasion and EMT in ESCC cells.
Bioinformatics analysis of the serine and glycine pathway in cancer cells.
Amelio et al., Roma, Italy. In Oncotarget, 2014
Employing 3 subsequent enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), phosphoserine aminotransferase 1 (PSAT1), 3-phosphoglycerate from glycolysis can be converted in serine, which in turn can by converted in glycine by serine methyl transferase (SHMT).
Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.
Wu et al., Wanxian, China. In World J Gastroenterol, 2014
The identified down-regulated proteins in CAPE-treated colorectal cancer cells were Triosephosphate Isomerase (Tim), Proteasome subunit alpha 4 (PSMA4) protein, Guanine nucleotide binding protein beta, Phosphoserine aminotransferase 1 (PSAT1), PSMA1, Myosin XVIIIB and Tryptophanyl-tRNA synthetase.
Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.
Zenker et al., Nijmegen, Netherlands. In Am J Hum Genet, 2014
Furthermore, we mapped an overlapping homozygous chromosome 9 region containing PSAT1 in four consanguineous families.
Site-specific metabolic phenotypes in metastatic breast cancer.
Koo et al., Seoul, South Korea. In J Transl Med, 2013
It was subject to immunohistochemical staining of the following proteins: Glycolysis-related: Glut-1, hexolinase II, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4; glutaminolysis-related: glutaminase (GLS) 1, glutamate dehydrogenase (GDH), and amino acid transporter (ASCT) 2; mitochondrial metabolism-related: ATP synthase, succinate dehydrogenase (SDH)A, and SDHB; and serine/glycine metabolism related: phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT), phosphoserine phosphatase (PSPH), glycine decarboxylase (GLDC), and serine hydroxymethyltransferase (SHMT).
Control of nutrient stress-induced metabolic reprogramming by PKCĪ¶ in tumorigenesis.
Moscat et al., Los Angeles, United States. In Cell, 2013
PKCĪ¶ represses the expression of two key enzymes of the pathway, PHGDH and PSAT1, and phosphorylates PHGDH at key residues to inhibit its enzymatic activity.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression.
Sawa et al., Japan. In Neurosci Res, 2011
we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions.
Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells.
Gongora et al., Montpellier, France. In Mol Cancer, 2007
Overexpression of phosphoserine aminotransferase is associated with colorectal cancer development
Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis.
Kim et al., Taegu, South Korea. In Biochem J, 2003
nucleotide sequence and enzymatic activity of two isoforms generated by alternative splicing; differential expression depending upon tissue specificity and cellular proliferation status
Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana.
Saito et al., Chiba, Japan. In Amino Acids, 2000
The 3-phosphoglycerate pathway (phosphorylated pathway) involves three enzymes catalyzing three sequential reactions: 3-phosphoglycerate dehydrogenase (PGDH), 3-phosphoserine aminotransferase (PSAT) and 3-phosphoserine phosphatase (PSP).
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