GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Trefoil factor 1
pS2, Presenilin-2, TFF1
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
pS2
antibodies
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
Supplier
In Journal of Biomedicine and Biotechnology, 2004
... We crossbred a Tg2576 male mouse with PS2 female mice using in vitro fertilization and embryo transfer techniques to generate PS2Tg2576 double transgenic mice born on the ...
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
Supplier
In Nature neuroscience, 1999
... Alterations in behavior, amyloid β-42, caspase-3, and COX-2 in mutant PS2 transgenic mouse model of Alzheimer's ...
Papers on
pS2
Let-7: A regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells.
New
Xi'an, China. In Oncol Rep, 06 Apr 2013
In additional experiments, we transfected a plasmid expressing let-7a into SP cells isolated from the MCF-7 and T47-D cell lines in order to observe changes in the expression of downstream genes (cyclin D1 and pS2).
ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis.
New
Taipei, Taiwan. In New Phytol, 25 Mar 2013
From a screen of mutants defective in genes that showed lower transcript abundance in per2 relative to wild-type roots on low Pi medium, we identified four putative downstream targets of AL6, namely ETC1, NPC4, SQD2 and PS2, all of which were critical in root hair elongation of Pi-deficient plants.
Quantitative measurements of trefoil factor family peptides: possibilities and pitfalls.
New
Århus, Denmark. In Scand J Clin Lab Invest, 08 Mar 2013
The trefoil factor family (TFF) peptides TFF1, TFF2, and TFF3 are produced and secreted by mucous membranes throughout the body.
EpCAM-associated claudin-7 supports lymphatic spread and drug-resistance in rat pancreatic cancer.
New
Heidelberg, Germany. In Int J Cancer, 06 Mar 2013
This requires cld7 phosphorylation and formation of an EpC-cld7-tetraspanin-alpha6beta4 complex in glycolipid-enriched membrane domains (GEM), where cld7 associates via the tetraspanin-alpha6beta4 complex with phosphorylated ezrin.
Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model.
New
Winston-Salem, United States. In Menopause, 04 Mar 2013
OBJECTIVE: Concerns of breast cancer risk in postmenopausal women taking combined estrogen + progestin therapy have generated interest in the use of selective estrogen receptor modulators (SERMs) as potential progestin alternatives.
Early-onset familial Alzheimer's disease (EOFAD).
Review
New
Canada. In Can J Neurol Sci, Jul 2012
To date, 230 mutations in presenilin (PS1, PS2) and amyloid precursor protein (APP) genes have been identified in EOFAD.
Review of theoretical studies for prediction of neurodegenerative inhibitors.
Review
New
Santiago de Compostela, Spain. In Mini Rev Med Chem, Jun 2012
While familial AD (FAD) is caused by autosomal dominant mutations in either amyloid precursor protein (APP) or the presenilin (PS1, PS2) genes.
Time sequence of oxidative stress in the brain from transgenic mouse models of Alzheimer's disease related to the amyloid-β cascade.
Review
New
Canada. In Free Radic Biol Med, Mar 2012
Rare early-onset forms of AD are associated with autosomal dominant mutations in the amyloid precursor protein gene, presenilin 1 gene, or presenilin 2 gene.
Characterization of nectin processing mediated by presenilin-dependent γ-secretase.
GeneRIF
Washington, D.C., United States. In J Neurochem, 2011
Presenilin 2 has the ability to regulate nectin-1 processing.
Review of synthesis, assay, and prediction of β and γ-secretase inhibitors.
Review
Santiago de Compostela, Spain. In Curr Top Med Chem, 2011
While familial AD (FAD) is caused by autosomal dominant mutations in either amyloid precursor protein (APP) or the presenilin (PS1, PS2) genes.
p53, a pivotal effector of a functional cross-talk linking presenilins and Pen-2.
Review
France. In Neurodegener Dis, 2011
This complex is composed of at least four distinct entities, namely presenilin-1 (PS1) or PS2, anterior pharynx defective-1, presenilin enhancer-2 (Pen-2) and nicastrin.
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
GeneRIF
Jena, Germany. In J Biol Chem, 2011
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and gamma-secretase complex stabilization
Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis.
GeneRIF
Houston, United States. In Pancreas, 2011
documented the extent and timing of TFF1 expression in pancreatic ductal adenocarcinoma
Loss of TFF1 is associated with activation of NF-κB-mediated inflammation and gastric neoplasia in mice and humans.
GeneRIF
Nashville, United States. In J Clin Invest, 2011
loss of TFF1 leads to activation of IKK complex-regulated NF-kappaB transcription factors and is an important event in shaping the NF-kappaB-mediated inflammatory response during the progression to gastric tumorigenesis
Trefoil factors: tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma.
GeneRIF
Khon Kaen, Thailand. In World J Gastroenterol, 2011
TFF mRNA/protein expression is indicative of cholangiocarcinoma progression, but not predictive for histological sub-type or survival time.
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women.
Impact
London, United Kingdom. In J Clin Oncol, 2010
Results The expression of many known estrogen-responsive genes and gene sets was highly significantly associated with plasma E2 levels (eg, TFF1/pS2, GREB1, PDZK1 and PGR; P < .005).
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.
Impact
Rochester, United States. In J Clin Oncol, 2009
Clinical trials typically enroll less than 10% of patients with a PS of 2 (PS2); thus, the benefit of systemic chemotherapy in PS2 patients is uncertain.
Nuclear signalling by tumour-associated antigen EpCAM.
Impact
München, Germany. In Nat Cell Biol, 2009
The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions.
Cyclical DNA methylation of a transcriptionally active promoter.
Impact
GeneRIF
Rennes, France. In Nature, 2008
Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens
Transient cyclical methylation of promoter DNA.
Impact
Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.
