Mitochondria-associated ER membranes in Alzheimer disease.
New York City, United States. In Mol Cell Neurosci, Jul 2013
We recently showed that presenilin-1 (PS1), presenilin-2 (PS2), and γ-secretase activity, which processes the amyloid precursor protein (APP) to generate Aβ, are located predominantly in a specialized subcompartment of the endoplasmic reticulum (ER) that is physically and biochemically connected to mitochondria, called mitochondria-associated ER membranes (MAM).
CSF Presenilin-1 complexes are increased in Alzheimer's disease.
San Juan de Alicante, Spain. In Acta Neuropathol Commun, Dec 2012
The γ-secretase components, APH-1 (anterior pharynx-defective 1) and PEN-2 (presenilin enhancer 2), as well as presenilin-2 (PS2) fragments, co-exist within these CSF complexes, while nicastrin is not detected.
Genetics of Alzheimer's disease.
Chiconcuac, Mexico. In Arch Med Res, Nov 2012
Mutations in the genes encoding amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) are responsible for early-onset autosomal dominant AD.
Transient cyclical methylation of promoter DNA.
Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.