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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Nov 2015.

Trefoil factor 1

pS2, Presenilin-2, TFF1
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, APP, HAD, AGE
Papers using pS2 antibodies
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
Shimizu Takahiko et al., In Journal of Biomedicine and Biotechnology, 2004
... We crossbred a Tg2576 male mouse with PS2 female mice using in vitro fertilization and embryo transfer techniques to generate PS2Tg2576 double transgenic mice born on the ...
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
Mucke Lennart et al., In Nature neuroscience, 1999
... Alterations in behavior, amyloid β-42, caspase-3, and COX-2 in mutant PS2 transgenic mouse model of Alzheimer's ...
Papers on pS2
Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review).
Obasaju et al., Houston, United States. In Int J Oncol, 29 Nov 2015
Our search identified a total of ten pemetrexed studies in PS2 patients.
Novel CARM1 Interacting Protein, DZIP3, is a Transcriptional Coactivator of Estrogen Receptor alpha.
Lee et al., Royal Oak, United States. In Mol Endocrinol, 27 Nov 2015
Depletion of DZIP3 by siRNA in MCF7 cells reduced estradiol induced gene expression of ERα target genes, GREB1 and pS2, and DZIP3 was recruited to the estrogen response elements of the same ERα target genes.
Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer.
Yang et al., Hengyang, China. In Clin Chim Acta, 23 Nov 2015
Trefoil factor family (TFF), composed of TFF1, TFF2, and TFF3, is a cluster of secreted peptides characterized by trefoil domain (s) and C-terminal dimerization domain.
Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants.
Synofzik et al., Tübingen, Germany. In Neurobiol Aging, 30 Oct 2015
These included 2 presenilin 2 (PSEN2) variants (p.N141I-previously denoted as a Volga German variant, observed in 2 index subjects; and p.L238P), 1 amyloid precursor protein (p.I716M), and 1 presenilin 1 (ΔE9).
What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis.
Russo et al., Palermo, Italy. In Crit Rev Oncol Hematol, Sep 2015
This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients.
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways.
St George-Hyslop et al., Toronto, Canada. In Mol Cell Neurosci, May 2015
Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of Aβ produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD).
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation.
Ehrlich et al., Chicago, United States. In Bmc Cancer, Dec 2014
RESULTS: Most of the assayed gene regions displayed hypermethylation in cancer vs. adjacent tissue but the TFF1 and MAGEA1 regions were significantly hypomethylated (p ≤0.001).
Mutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disorders.
Kim et al., South Korea. In Clin Interv Aging, Dec 2014
Mutations in the genes encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein have been identified as the main genetic causes of familial AD.
Autosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical AD.
Fagan et al., Saint Louis, United States. In Front Neurol, Dec 2014
Mutations in the genes coding for amyloid precursor protein (APP), presenilin 1 (PSEN-1), and presenilin 2 (PSEN-2) cause over-production of the amyloid-β peptide (Aβ) leading to early deposition of Aβ in the brain, which in turn is hypothesized to initiate a cascade of processes, resulting in neuronal death, cognitive decline, and eventual dementia.
Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain.
Wang et al., San Diego, United States. In Bmc Res Notes, Dec 2014
A number of CTD-binding proteins have been identified and the crystal structures of several protein-CTD complexes have demonstrated considerable conformational flexibility of the heptad repeats in those interactions.
Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients.
Singleton et al., İstanbul, Turkey. In Neurobiol Aging, 2012
Here we report a frequency of 11.2% of mutations and variants in the known Alzheimer disease genes in the dementia cohort studied and 24% in the early onset subgroup of patients
Presenilin-2 polymorphisms and risk of sporadic AD: evidence from a meta-analysis.
Yu et al., Chongqing, China. In Gene, 2012
analysis supports the hypothesis that the PSEN2 rs8383 polymorphism is associated with an enlarged risk of sporadic Alzheimer's disease
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Sisodia et al., Chicago, United States. In J Neurosci, 2012
transcriptome studies of presenilin knockout mise mouse brains reveal, for the first time, a role for presenilins in regulating lysosomal biogenesis
TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro.
Wang et al., Shanghai, China. In Bosn J Basic Med Sci, 2012
Over-expression of TFF1 could promote apoptosis of three cell lines and inhibit proliferation but had no pronounced effect on cell cycle
[Familial Alzheimer disease].
Tsuji et al., Tokyo, Japan. In Nihon Rinsho, 2011
Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women.
Dowsett et al., London, United Kingdom. In J Clin Oncol, 2010
Results The expression of many known estrogen-responsive genes and gene sets was highly significantly associated with plasma E2 levels (eg, TFF1/pS2, GREB1, PDZK1 and PGR; P < .005).
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.
Goldberg et al., Rochester, United States. In J Clin Oncol, 2009
Clinical trials typically enroll less than 10% of patients with a PS of 2 (PS2); thus, the benefit of systemic chemotherapy in PS2 patients is uncertain.
Nuclear signalling by tumour-associated antigen EpCAM.
Gires et al., München, Germany. In Nat Cell Biol, 2009
The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions.
Cyclical DNA methylation of a transcriptionally active promoter.
Salbert et al., Rennes, France. In Nature, 2008
Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens
Transient cyclical methylation of promoter DNA.
Reid et al., Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.
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