gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Trefoil factor 1

pS2, Presenilin-2, TFF1
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, APP, Estrogen Receptor, AGE
Papers using pS2 antibodies
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
Supplier
Shimizu Takahiko et al., In Journal of Biomedicine and Biotechnology, 2004
... We crossbred a Tg2576 male mouse with PS2 female mice using in vitro fertilization and embryo transfer techniques to generate PS2Tg2576 double transgenic mice born on the ...
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
Supplier
Mucke Lennart et al., In Nature neuroscience, 1999
... Alterations in behavior, amyloid β-42, caspase-3, and COX-2 in mutant PS2 transgenic mouse model of Alzheimer's ...
Papers on pS2
Redox hydrogels with adjusted redox potential for improved efficiency in Z-scheme inspired biophotovoltaic cells.
New
Rögner et al., Bochum, Germany. In Phys Chem Chem Phys, 20 Apr 2014
The anode is based on photosystem 2 (PS2) integrated in a phenothiazine modified redox hydrogel with a formal potential of -1 mV vs. SHE, which is 59 mV more positive than the QB acceptor site in PS2.
Slow overmethylation of housekeeping genes in the body mucosa is associated with the risk for gastric cancer.
New
Hong et al., South Korea. In Cancer Prev Res (phila), 20 Apr 2014
pylori) infection increases age-related diverse overmethylation in gene-control regions, which increases the risk of gastric cancer.
Familial Alzheimer's disease sustained by presenilin 2 mutations: Systematic review of literature and genotype-phenotype correlation.
Review
New
Bruno et al., Roma, Italy. In Neurosci Biobehav Rev, 01 Apr 2014
Overall, the mutations involving the PSEN2 gene represent an extremely rare cause of FAD, having been reported to date in less than 200 cases.
Mutational analysis in early-onset familial Alzheimer's disease in Mainland China.
New
Shen et al., Changsha, China. In Neurobiol Aging, 20 Mar 2014
UNLABELLED: Mutations of 3 causative genes, namely presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP), have been identified as the major causes of early-onset familial Alzheimer's disease (EOFAD).
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
New
Sood et al., Houston, United States. In Nat Commun, Dec 2013
We find enhanced potency stems from an unforeseen increase in siRNA loading to the RNA-induced silencing complex, likely due to the unique interaction mediated by 2'-OMe and PS2.
Early Onset Alzheimer's Disease and Oxidative Stress.
Review
New
Campos-Peña et al., Mexico. In Oxid Med Cell Longev, Dec 2013
Mutations in APP, PS1, and PS2 genes are causes for early onset AD.
Gene expression markers in circulating tumor cells may predict bone metastasis and response to hormonal treatment in breast cancer.
New
Wang et al., Rochester, United States. In Mol Clin Oncol, Nov 2013
Among the genes that constitute this signature, trefoil factor 1 (TFF1) was identified as the most differentially expressed gene associated with bone metastasis.
Quantitative measurements of trefoil factor family peptides: possibilities and pitfalls.
Review
New
Samson, Århus, Denmark. In Scand J Clin Lab Invest, Apr 2013
The trefoil factor family (TFF) peptides TFF1, TFF2, and TFF3 are produced and secreted by mucous membranes throughout the body.
A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.
Review
Adamski et al., Québec, Canada. In Curr Top Med Chem, 2012
Surprisingly, these multi-catalyses can combine synergistically in vitro and in vivo and their dysfunction may result in the stimulation of breast or prostate cancer.
Genetics of familial and sporadic Alzheimer's disease.
Review
Sorbi et al., Florence, Italy. In Front Biosci (elite Ed), 2012
The familial form is due to mutations in three major genes (amyloid precursor protein (APP) gene, presenilin1 (PSEN1) gene and presenilin 2 (PSEN2) gene).
Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients.
GeneRIF
Singleton et al., İstanbul, Turkey. In Neurobiol Aging, 2012
Here we report a frequency of 11.2% of mutations and variants in the known Alzheimer disease genes in the dementia cohort studied and 24% in the early onset subgroup of patients
Presenilin-2 polymorphisms and risk of sporadic AD: evidence from a meta-analysis.
GeneRIF
Yu et al., Chongqing, China. In Gene, 2012
analysis supports the hypothesis that the PSEN2 rs8383 polymorphism is associated with an enlarged risk of sporadic Alzheimer's disease
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
GeneRIF
Sisodia et al., Chicago, United States. In J Neurosci, 2012
transcriptome studies of presenilin knockout mise mouse brains reveal, for the first time, a role for presenilins in regulating lysosomal biogenesis
TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro.
GeneRIF
Wang et al., Shanghai, China. In Bosn J Basic Med Sci, 2012
Over-expression of TFF1 could promote apoptosis of three cell lines and inhibit proliferation but had no pronounced effect on cell cycle
[Familial Alzheimer disease].
GeneRIF
Tsuji et al., Tokyo, Japan. In Nihon Rinsho, 2011
Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women.
Impact
Dowsett et al., London, United Kingdom. In J Clin Oncol, 2010
Results The expression of many known estrogen-responsive genes and gene sets was highly significantly associated with plasma E2 levels (eg, TFF1/pS2, GREB1, PDZK1 and PGR; P < .005).
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.
Impact
Goldberg et al., Rochester, United States. In J Clin Oncol, 2009
Clinical trials typically enroll less than 10% of patients with a PS of 2 (PS2); thus, the benefit of systemic chemotherapy in PS2 patients is uncertain.
Nuclear signalling by tumour-associated antigen EpCAM.
Impact
Gires et al., München, Germany. In Nat Cell Biol, 2009
The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions.
Cyclical DNA methylation of a transcriptionally active promoter.
Impact
GeneRIF
Salbert et al., Rennes, France. In Nature, 2008
Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens
Transient cyclical methylation of promoter DNA.
Impact
Reid et al., Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.
share on facebooktweetadd +1mail to friends