DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival.
In Breast Cancer Res, 07 Nov 2014
Genes relatively hypermethylated in HR+, luminal A, or p53 wildtype breast cancers included FABP3, FGF2, FZD9, GAS7, HDAC9, HOXA11, MME, PAX6, POMC, PTGS2, RASSF1, RBP1, and SCGB3A1, while those more highly methylated in HR-, basal-like or p53 mutant tumors included BCR, C4B, DAB2IP, MEST, RARA, SEPT5, TFF1, THY1 and SERPINA5.
Disease-related mutations among Caribbean Hispanics with familial dementia.
Santiago de los Caballeros, Dominican Republic. In Mol Genet Genomic Med, 30 Sep 2014
Pathogenic mutations in the three known genes - the amyloid precursor protein (APP), presenilin 1 (PSEN1), presenilin 2 (PSEN2) - are known to cause familial Alzheimer's disease (AD) and tend to be associated with early-onset AD.
[Familial Alzheimer disease].
Tokyo, Japan. In Nihon Rinsho, 2011
Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.
Transient cyclical methylation of promoter DNA.
Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.