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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Nov 2014.

Trefoil factor 1

pS2, Presenilin-2, TFF1
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, APP, Estrogen Receptor, HAD
Papers using pS2 antibodies
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
Supplier
Shimizu Takahiko et al., In Journal of Biomedicine and Biotechnology, 2004
... We crossbred a Tg2576 male mouse with PS2 female mice using in vitro fertilization and embryo transfer techniques to generate PS2Tg2576 double transgenic mice born on the ...
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
Supplier
Mucke Lennart et al., In Nature neuroscience, 1999
... Alterations in behavior, amyloid β-42, caspase-3, and COX-2 in mutant PS2 transgenic mouse model of Alzheimer's ...
Papers on pS2
Trefoil Factor Expression in a Human Model of the Early Stages of Barrett's Esophagus.
New
Griffin et al., Newcastle upon Tyne, United Kingdom. In Dig Dis Sci, 26 Dec 2014
TFF1 and TFF2 were expressed by all samples in a similar pattern to that described in studies of sporadic Barrett's esophagus.
Development of cell-penetrating r7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.
New
Kurihara et al., Tokyo, Japan. In Bioconjug Chem, 19 Dec 2014
The R7-conjugated peptide 5 was able to enter ER-positive T47D cells efficiently, and treatment with 3 μM of 5 downregulated the mRNA expression of pS2 (an ER-mediated gene) by 87%.
The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer.
New
Noshiro et al., Saga, Japan. In Int J Oncol, 17 Dec 2014
UNLABELLED: The trefoil factor (TFF) family comprises three thermo-stable and protease-resistant proteins (TFF1, TFF2 and TFF3) and plays an essential role in gastrointestinal mucosa protection and regeneration, and TFFs have recently been found to be involved in the development and progression of various types of cancer.
Differences in expression of proliferation-associated genes and RANKL across the menstrual cycle in estrogen receptor-positive primary breast cancer.
New
Dowsett et al., London, United Kingdom. In Breast Cancer Res Treat, 30 Nov 2014
The purpose of this study is to determine if there are differences in the expression of estrogen-regulated genes (ERGs), proliferation-associated genes and the progesterone effector RANKL, in premenopausal ER+ breast cancer as a result of the major changes in hormone levels that occur through the menstrual cycle.
Genetic markers for diagnosis and pathogenesis of Alzheimer's disease.
Review
New
Cha et al., Pusan, South Korea. In Gene, Aug 2014
Mutations in the genes encoding amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) are responsible for early-onset autosomal dominant AD.
Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime.
Review
New
Nixon et al., United States. In Biochem Soc Trans, Dec 2013
Early-onset FAD (familial Alzheimer's disease) is caused by mutations of PS1 (presenilin 1), PS2 (presenilin 2) and APP (amyloid precursor protein).
Early molecular changes in Alzheimer disease: can we catch the disease in its presymptomatic phase?
Review
New
Bossers et al., Amsterdam, Netherlands. In J Alzheimers Dis, Dec 2013
While the familial, early onset form of AD is known to be caused by specific mutations in genes encoding presenilin 1, presenilin 2, or amyloid-β protein precursor, the underlying mechanisms leading to the development of sporadic AD are still not known.
The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.
Review
New
Brayne et al., Cambridge, United Kingdom. In Mol Neurobiol, Dec 2013
FAD is associated with various genetic mutations in the amyloid precursor protein (APP) and the presenilins (PS)1 and PS2.
Protein loop modeling using a new hybrid energy function and its application to modeling in inaccurate structural environments.
New
Seok et al., Seoul, South Korea. In Plos One, Dec 2013
Until recently, the majority of loop modeling methods have been developed and tested by reconstructing loops in frameworks of experimentally resolved structures.
A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.
Review
Adamski et al., Québec, Canada. In Curr Top Med Chem, 2012
Surprisingly, these multi-catalyses can combine synergistically in vitro and in vivo and their dysfunction may result in the stimulation of breast or prostate cancer.
Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients.
GeneRIF
Singleton et al., İstanbul, Turkey. In Neurobiol Aging, 2012
Here we report a frequency of 11.2% of mutations and variants in the known Alzheimer disease genes in the dementia cohort studied and 24% in the early onset subgroup of patients
Presenilin-2 polymorphisms and risk of sporadic AD: evidence from a meta-analysis.
GeneRIF
Yu et al., Chongqing, China. In Gene, 2012
analysis supports the hypothesis that the PSEN2 rs8383 polymorphism is associated with an enlarged risk of sporadic Alzheimer's disease
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
GeneRIF
Sisodia et al., Chicago, United States. In J Neurosci, 2012
transcriptome studies of presenilin knockout mise mouse brains reveal, for the first time, a role for presenilins in regulating lysosomal biogenesis
TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro.
GeneRIF
Wang et al., Shanghai, China. In Bosn J Basic Med Sci, 2012
Over-expression of TFF1 could promote apoptosis of three cell lines and inhibit proliferation but had no pronounced effect on cell cycle
[Familial Alzheimer disease].
GeneRIF
Tsuji et al., Tokyo, Japan. In Nihon Rinsho, 2011
Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women.
Impact
Dowsett et al., London, United Kingdom. In J Clin Oncol, 2010
Results The expression of many known estrogen-responsive genes and gene sets was highly significantly associated with plasma E2 levels (eg, TFF1/pS2, GREB1, PDZK1 and PGR; P < .005).
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.
Impact
Goldberg et al., Rochester, United States. In J Clin Oncol, 2009
Clinical trials typically enroll less than 10% of patients with a PS of 2 (PS2); thus, the benefit of systemic chemotherapy in PS2 patients is uncertain.
Nuclear signalling by tumour-associated antigen EpCAM.
Impact
Gires et al., München, Germany. In Nat Cell Biol, 2009
The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions.
Cyclical DNA methylation of a transcriptionally active promoter.
Impact
GeneRIF
Salbert et al., Rennes, France. In Nature, 2008
Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens
Transient cyclical methylation of promoter DNA.
Impact
Reid et al., Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.
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