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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Trefoil factor 1

pS2, Presenilin-2, TFF1
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, APP, HAD, AGE
Papers using pS2 antibodies
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
Supplier
Shimizu Takahiko et al., In Journal of Biomedicine and Biotechnology, 2004
... We crossbred a Tg2576 male mouse with PS2 female mice using in vitro fertilization and embryo transfer techniques to generate PS2Tg2576 double transgenic mice born on the ...
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
Supplier
Mucke Lennart et al., In Nature neuroscience, 1999
... Alterations in behavior, amyloid β-42, caspase-3, and COX-2 in mutant PS2 transgenic mouse model of Alzheimer's ...
Papers on pS2
Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest.
New
Czuczwar et al., Warsaw, Poland. In Pharmacol Rep, 29 Feb 2016
Consequently, we have examined quantitative changes in both presenilin 1 and 2 genes in the medial temporal lobe cortex following 10-min global brain ischemia in rats.
Effects of different limestone particle sizes in the diet of broiler breeders post molting on their performance, egg quality, incubation results, and pre-starter performance of their progeny.
New
Maiorka et al., Curitiba, Brazil. In Poult Sci, 14 Feb 2016
In total, 640 broiler breeder females, 73-week-old and sixty-four 27-week-old cockerels, Cobb 500, were evaluated during 10 weeks, according to a randomized block design composed of 4 treatments with 8 replicates each.
Mechanics of an Asymmetric Hard-Soft Lamellar Nanomaterial.
New
Creton et al., In Acs Nano, 13 Feb 2016
UNASSIGNED: Nano-layered lamellae are common structures in nanoscience and nanotechnology, but most are nearly symmetric in layer thickness.
Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol.
New
Sreeja et al., Thiruvananthapuram, India. In Iubmb Life, 12 Feb 2016
Our recent research shed light on the possible SERM-like property of methanol extract of pericarp of pomegranate (PME) by using human breast (MCF-7, MDA-MB-231), endometrial (HEC-1A), cervical (SiHa, HeLa), ovarian (SKOV3) cancer cell lines, normal breast fibroblasts (MCF-10A) and also by in vivo models (ovariectomized Swiss albino mice).
Exemestane use in postmenopausal women at high risk for invasive breast cancer: evaluating biomarkers of efficacy and safety.
New
Eng-Wong et al., Georgetown, Guyana. In Cancer Prev Res (phila), 12 Feb 2016
Secondary outcomes included change in serum steroid hormones as well as change in trefoil protein 1 (TFF1) and proliferating cell nuclear antigen (PCNA) in breast tissue.
"Hemin/G-quadruplex structure and activity alteration induced by magnesium cations".
New
Juskowiak et al., Poznań, Poland. In Int J Biol Macromol, 08 Feb 2016
It has been demonstrated that G-quadruplex based on PS2.M sequence under these conditions formed parallel topology, which exhibited lower activity than that observed in standard potassium-containing solution.
Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.
New
Xu et al., Knoxville, United States. In J Neurochem, 30 Jan 2016
UNASSIGNED: The γ-secretase complex is composed of at least four components: presenilin (PS1 or PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (pen-2).
SWOG S0709: Randomized Phase II Trial of Erlotinib Versus Erlotinib Plus Carboplatin/Paclitaxel in Patients with Advanced Non-Small Cell Lung Cancer and Impaired Performance Status as Selected by a Serum Proteomics Assay.
New
Gandara et al., Sacramento, United States. In J Thorac Oncol, 24 Jan 2016
In light of the potential role for serum proteomics in predicting the benefit of erlotinib beyond that of epidermal growth factor receptor gene (EGFR) mutational status, we conducted a trial in which the Veristrat proteomics assay was used for data enrichment when selecting a cohort of patients with NSCLC and PS2 to receive erlotinib with and without chemotherapy.
Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice.
New
Kondo et al., Fujisawa, Japan. In Brain Res, 17 Jan 2016
UNASSIGNED: Mutations in presenilin 1 (PS1) and presenilin 2 (PS2) are known to cause early onset of Alzheimer׳s disease (AD).
Simultaneous measurements of photocurrents and H2O2 evolution from solvent exposed photosystem 2 complexes.
Rögner et al., Bochum, Germany. In Biointerphases, 2014
In plants, algae, and cyanobacteria, photosystem 2 (PS2) catalyzes the light driven oxidation of water.
Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients.
GeneRIF
Singleton et al., İstanbul, Turkey. In Neurobiol Aging, 2012
Here we report a frequency of 11.2% of mutations and variants in the known Alzheimer disease genes in the dementia cohort studied and 24% in the early onset subgroup of patients
Presenilin-2 polymorphisms and risk of sporadic AD: evidence from a meta-analysis.
GeneRIF
Yu et al., Chongqing, China. In Gene, 2012
analysis supports the hypothesis that the PSEN2 rs8383 polymorphism is associated with an enlarged risk of sporadic Alzheimer's disease
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
GeneRIF
Sisodia et al., Chicago, United States. In J Neurosci, 2012
transcriptome studies of presenilin knockout mise mouse brains reveal, for the first time, a role for presenilins in regulating lysosomal biogenesis
TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro.
GeneRIF
Wang et al., Shanghai, China. In Bosn J Basic Med Sci, 2012
Over-expression of TFF1 could promote apoptosis of three cell lines and inhibit proliferation but had no pronounced effect on cell cycle
[Familial Alzheimer disease].
GeneRIF
Tsuji et al., Tokyo, Japan. In Nihon Rinsho, 2011
Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women.
Impact
Dowsett et al., London, United Kingdom. In J Clin Oncol, 2010
Results The expression of many known estrogen-responsive genes and gene sets was highly significantly associated with plasma E2 levels (eg, TFF1/pS2, GREB1, PDZK1 and PGR; P < .005).
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.
Impact
Goldberg et al., Rochester, United States. In J Clin Oncol, 2009
Clinical trials typically enroll less than 10% of patients with a PS of 2 (PS2); thus, the benefit of systemic chemotherapy in PS2 patients is uncertain.
Nuclear signalling by tumour-associated antigen EpCAM.
Impact
Gires et al., München, Germany. In Nat Cell Biol, 2009
The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions.
Transient cyclical methylation of promoter DNA.
Impact
Reid et al., Heidelberg, Germany. In Nature, 2008
We reported previously that the proximal region of the trefoil factor 1 (TFF1, also known as pS2) and oestrogen receptor alpha (ERalpha) promoters could be partially methylated by treatment with deacetylase inhibitors, suggesting the possibility of dynamic changes in DNA methylation.
Cyclical DNA methylation of a transcriptionally active promoter.
Impact
GeneRIF
Salbert et al., Rennes, France. In Nature, 2008
Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens
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