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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PRP4 Prp4p

PRP4, Prp4p
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, ACID, CAN, STEP, PIF
Papers on PRP4
The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.
New
Messana et al., Cagliari, Italy. In J Proteomics, Oct 2015
Maturation process generates ten aPRPs (PRP-1, PRP-2, PIF-s, Db-s, Pa, PRP-3, PRP-4, PIF-f, Db-f, P-C), and at least 18 bPRPs (II-2, P-E, IB-6, Ps-1, Ps-2, IB-1, P-J, IB-8a, P-F, P-H, P-D, II-1, protein glycosylated A, CD-IIg, and Gl1-4).
Proteomics Differentiate Between Thyroid-Associated Orbitopathy and Dry Eye Syndrome.
New
Kahaly et al., Mainz, Germany. In Invest Ophthalmol Vis Sci, Apr 2015
proline-rich protein 4 (PRP4, P < 0.05), S10A8 (P = 0.004) and SMCA4 (P = 0.002) were downregulated in TAO.
Proteome-wide discovery of unknown ATP-binding proteins and kinase inhibitor target proteins using an ATP probe.
Tomonaga et al., Ibaraki, Japan. In J Proteome Res, 2015
We also found multiple ATP-competitive sites for several kinases, including epidermal growth factor receptor, serine/threonine-protein kinase PRP4 homologue, cyclin-dependent kinase 12, eukaryotic elongation factor 2 kinase, ribosomal protein S6 kinase alpha-1, and SRSF protein kinase 1.
Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
Huang et al., Vitry-sur-Seine, France. In J Biol Chem, 2013
PRP4 kinase is known for its roles in regulating pre-mRNA splicing and beyond.
Competition between pre-mRNAs for the splicing machinery drives global regulation of splicing.
Ares et al., Santa Cruz, United States. In Mol Cell, 2013
Downregulation of the RPG-dedicated transcription factor gene IFH1 genetically suppresses two spliceosome mutations, prp11-1 and prp4-1, and globally restores splicing efficiency in prp4-1 cells.
Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe.
Trakovicka et al., Nitra, Slovakia. In Acta Biochim Pol, 2012
The Schizosaccharomyces pombe Prp4 is an essential serine/threonine protein kinase, which belongs to the Clk/Sty family.
Proteomics of tear fluid in thyroid-associated orbitopathy.
Kahaly et al., Mainz, Germany. In Thyroid, 2012
They were identified as proline-rich protein 4 (PRP4) or as its variant nasopharyngeal carcinoma-associated PRP4.
LACHESIS-dependent egg-cell signaling regulates the development of female gametophytic cells.
Gross-Hardt et al., Tübingen, Germany. In Development, 2012
LIS codes for the Arabidopsis homolog of the pre-mRNA splicing factor PRP4 and shows a dynamic expression pattern in the maturing female gametophyte.
MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.
Holmberg et al., Copenhagen, Denmark. In Plos One, 2011
Genetic interactions are observed between 2 µm-MRN1 and the splicing deficient mutants snt309Δ, prp3, prp4, and prp22, and additional genetic analyses link MRN1, SNT309, NHP6A/B, SWI/SNF, and RSC supporting the notion of a role of chromatin structure in mRNA processing.
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
GeneRIF
Lührmann et al., Göttingen, Germany. In Nat Struct Mol Biol, 2010
The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes.
Changed profile of splicing regulator genes expression in response to exercise.
GeneRIF
Sakharov et al., Moscow, Russia. In Bull Exp Biol Med, 2009
Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: PRPF4B.
CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants.
Gross-Hardt et al., Tübingen, Germany. In Plant J, 2008
We have previously shown that, in lis mutants, which are defective for the splicing factor PRP4, accessory cells can differentiate gametic cell fate.
Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.
GeneRIF
Hornicek et al., Boston, United States. In Mol Cancer Ther, 2008
PRP-4 belongs to the serine/threonine protein kinase family, plays a role in pre-mRNA splicing and cell mitosis, and interacts with CLK1
Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A.
Kimura et al., Kyoto, Japan. In Genes Cells, 2008
We performed a comparative study of different SR kinases, including SRPK, Clk, PRP4 and DYRK, and found that only Clks efficiently altered 5' splice site selection of Adenovirus E1A.
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
GeneRIF
Giet et al., Rennes, France. In J Cell Biol, 2007
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.
GeneRIF
Krensky et al., Stanford, United States. In J Immunol, 2007
PRP4, a serine/threonine protein kinase, is identified as a Kruppel-like factor 13 (KLF13)-binding protein; PRP4 phosphorylates KLF13
A kinetic-dynamic model for regulatory RNA processing.
Review
Yu et al., Taipei, Taiwan. In J Biotechnol, 2007
The model was finally applied on time series data of yeast prp4-l mutant cells for determination of rates of RNA processing.
Pre-mRNA splicing in Schizosaccharomyces pombe: regulatory role of a kinase conserved from fission yeast to mammals.
Review
Käufer et al., Braunschweig, Germany. In Curr Genet, 2003
The focus is on Prp4p kinase, first discovered in fission yeast and also present in mammals, but absent in Sac.
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