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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

PRP4 Prp4p

PRP4, Prp4p
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PRP4
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
GeneRIF
Lührmann et al., Göttingen, Germany. In Nat Struct Mol Biol, 2010
The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes.
Changed profile of splicing regulator genes expression in response to exercise.
GeneRIF
Sakharov et al., Moscow, Russia. In Bull Exp Biol Med, 2009
Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: PRPF4B.
Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.
GeneRIF
Hornicek et al., Boston, United States. In Mol Cancer Ther, 2008
PRP-4 belongs to the serine/threonine protein kinase family, plays a role in pre-mRNA splicing and cell mitosis, and interacts with CLK1
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
GeneRIF
Giet et al., Rennes, France. In J Cell Biol, 2007
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.
GeneRIF
Krensky et al., Stanford, United States. In J Immunol, 2007
PRP4, a serine/threonine protein kinase, is identified as a Kruppel-like factor 13 (KLF13)-binding protein; PRP4 phosphorylates KLF13
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