MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.
Copenhagen, Denmark. In Plos One, 2011
Genetic interactions are observed between 2 µm-MRN1 and the splicing deficient mutants snt309Δ, prp3, prp4, and prp22, and additional genetic analyses link MRN1, SNT309, NHP6A/B, SWI/SNF, and RSC supporting the notion of a role of chromatin structure in mRNA processing.
Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.
Praha, Czech Republic. In J Cell Biochem, 2009
Using a synthetic lethality screen, we found that prp45(1-169) genetically interacts with alleles of NTC members SYF1, CLF1/SYF3, NTC20, and CEF1, and 2nd step splicing factors SLU7, PRP17, PRP18, and PRP22.
Functional domains of the yeast splicing factor Prp22p.
New York City, United States. In J Biol Chem, 2001
Here we delineate a minimal functional domain, Prp22(262-1145), that suffices for the activity of Prp22p in vivo when expressed under the natural PRP22 promoter and for pre-mRNA splicing activity in vitro.