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PRP21 Prp21p

PRP21, SF3a120, Prp21p, SPP91, SAP 114, SF3A1
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PRP9, PRP11, CAN, GAPDH, STEP
Papers on PRP21
SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer.
New
Wang et al., Beijing, China. In Oncotarget, Dec 2015
A two-stage case-control study was conducted to examine the association between six candidate U2-depedent spliceosome genes (SRSF1, SRSF2, SF3A1, SF3B1, SF1 and PRPF40B) and pancreatic cancer (PC).
[Research on the association between U2-dependent spliceosome gene and hepatocellular cancer].
New
Wang et al., Beijing, China. In Zhonghua Liu Xing Bing Xue Za Zhi, Jun 2015
RESULTS: The rs5994293 in SF3A1 gene showed a significant association with HCC in both screened population and combined population.
The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population.
Zhong et al., Wuhan, China. In Plos One, 2014
However, the role of SF3A1, one key component of the mRNA splicing machinery, on colorectal cancer (CRC) risk was still not elucidated.
The importance of reference gene analysis of formalin-fixed, paraffin-embedded samples from sarcoma patients - an often underestimated problem.
Sørensen et al., Århus, Denmark. In Transl Oncol, 2014
However, PPIA, SF3A1, and MRPL19 were stably expressed regardless of the histologic type included.
Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step.
Kay et al., Chicago, United States. In Int J Mol Sci, 2014
We demonstrate the utility of this approach by generating low nanomolar fibronectin type III (FN3) monobodies to five human proteins: ubiquitin-conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen-activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11).
Stable reference genes in granulosa cells of bovine dominant follicles during follicular growth, FSH stimulation and maternal aging.
Singh et al., In Reprod Fertil Dev, 2014
The mRNA levels of the two commonly used reference genes (GAPDH, ACTB) and four novel genes (UBE2D2, EIF2B2, SF3A1, RNF20) were analysed using cycle threshold values.
Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.
Black et al., Phoenix, United States. In Genes Dev, 2014
We show that U1-SL4 interacts with the SF3A1 protein of the U2 snRNP.
Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia.
Rasko et al., Australia. In Cancer Sci, 2014
Here, we examined promoter DNA hypermethylation of nine splicing factors, SF3B1, SRSF2, U2AF1, ZRSR2, SF3A1, HNRNPR, MATR3, ZFR, and YBX3 in 10 leukemic cell lines and 94 MDS or AML patient samples from the Australasian Leukemia and Lymphoma Group Tissue Bank.
Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells.
Prigent et al., Rennes, France. In Embo Rep, 2014
Inactivation of splicing factors SF3a120 and U2AF65 induces similar cohesion defects to Prp19 complex inactivation.
Validation of housekeeping genes for studying differential gene expression in the bovine myometrium.
Kotwica et al., Olsztyn, Poland. In Acta Vet Hung, 2013
NormFinder identified the best genes in the myometrium as C2orf29, MRPL12 and TBP, while the worst genes were 18S RNA, B2M and SF3A1.
Proteins associated with SF3a60 in T. brucei.
Levin et al., Buenos Aires, Argentina. In Plos One, 2013
The interactions with SF3a120, SF3a66 and SAP130 were confirmed by tandem affinity purification and mass spectrometry.
Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial.
Hellström-Lindberg et al., Stockholm, Sweden. In Blood Cancer J, 2013
Although no single mutation predicted for response, SF3A1 (n=3) and DNMT3A (n=4) were only observed in non-responders.
The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.
Review
Quintás-Cardama et al., Houston, United States. In Mol Cancer Res, 2013
UNLABELLED: Over the past few years, large-scale genomic studies of patients with myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have unveiled recurrent somatic mutations in genes involved in epigenetic regulation (DNMT3A, IDH1/2, TET2, ASXL1, EZH2 and MLL) and the spliceosomal machinery (SF3B1, U2AF1, SRSF2, ZRSR2, SF3A1, PRPF40B, U2AF2, and SF1).
High-throughput identification of reference genes for research and clinical RT-qPCR analysis of breast cancer samples.
Tonevitsky et al., Moscow, Russia. In J Clin Bioinforma, 2012
RESULTS: A set of five reference genes was identified: ACTB, RPS23, HUWE1, EEF1A1 and SF3A1.
Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.
GeneRIF
Krämer et al., Genève, Switzerland. In Mol Biol Cell, 2005
SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing
Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex.
Impact
Chapon et al., Paris, France. In Science, 1993
Protein-protein interactions have been identified between two Saccharomyces cerevisiae yeast splicing factors, PRP9 and SPP91.
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