GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
PRP19 Prp19p
Prp19, PSO4, Prp19p, SNEV
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008] (from
NCBI)
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Ubiquitin, STEP, CAN, ACID, V1a
Papers on
Prp19
SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA induced senescence in mouse skin.
New
Vienna, Austria. In Exp Dermatol, Jan 2016
SNEV(P) (rp19/) (PSO) (4) is a multifaceted protein, known to be involved in DNA damage repair and senescence, albeit only in vitro.
Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
New
Beijing, China. In Development, Dec 2015
BCAS2 (breast carcinoma amplified sequence 2), a core component of the PRP19 complex involved in pre-mRNA splicing, plays an important role in the DNA damage response through the RPA complex, a key regulator in the maintenance of genome integrity.
The spliceosomal PRP19 complex of trypanosomes.
New
Farmington, United States. In Mol Microbiol, Mar 2015
Here, we characterize the non-snRNP PRP19 complex of Trypanosoma brucei.
PRP19 upregulation inhibits cell proliferation in lung adenocarcinomas by p21-mediated induction of cell cycle arrest.
Dalian, China. In Biomed Pharmacother, 2014
Precursor messenger RNA processing factor 19 (PRP19) is known to be a critical component of the eukaryotic spliceosomal machinery and DNA damage repair system, the deregulation of which leads to many disease conditions.
The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR).
Hangzhou, China. In J Biol Chem, 2014
The PSO4 core complex is composed of PSO4/PRP19/SNEV, CDC5L, PLRG1, and BCAS2/SPF27.
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Boston, United States. In Mol Cell, 2014
PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR).
Splicing and beyond: the many faces of the Prp19 complex.
Review
Martinsried, Germany. In Biochim Biophys Acta, 2013
The conserved Prp19 complex (Prp19C) - also known as NineTeen Complex (NTC) - functions in several processes of paramount importance for cellular homeostasis.
RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery.
Barcelona, Spain. In Plos Genet, 2013
PRP-8 is a core component of the spliceosome and PRP-19 is the core component of the PRP19 complex, which interacts with RNAPII and is necessary for full transcriptional activity.
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.
Shanghai, China. In Biochim Biophys Acta, 2013
Subsequently, we utilized Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) to identify differentially expressed proteins in UCH37 over-expressing cells compared with the control cells, and found that PRP19, an essential RNA splicing factor, was up-regulated.
A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans.
Kōbe, Japan. In Mol Cell Biol, 2013
This leakage was also observed with the depletion of several splicing factors, including SF3b, IBP160, and PRP19, all of which genetically interacted with Y14.
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
GeneRIF
Vienna, Austria. In Aging (albany Ny), 2012
SNEV phosphorylation at S149 is essential for mediating the cytoprotective effect of SNEV upon DNA damage/oxidative stress and partially contributes to the life span extension caused by SNEV overexpression.
Structure of the mRNA splicing complex component Cwc2: insights into RNA recognition.
GeneRIF
Beijing, China. In Biochem J, 2012
we provide the first piece of evidence that the linker sequences outside the RNA recognition motif (RRM) - those connecting the ZnF domain and the RRM of the Prp19-associated complex - directly interact with RNA
Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA.
Vienna, Austria. In Plos One, 2011
Originally the novel protein Blom7α was identified as novel pre-mRNA splicing factor that interacts with SNEV(Prp19/Pso4), an essential protein involved in extension of human endothelial cell life span, DNA damage repair, the ubiquitin-proteasome system, and pre-mRNA splicing.
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.
GeneRIF
New York City, United States. In Genes Dev, 2011
U2AF65 binds directly to the phosphorylated C-terminal domain, and that this interaction results in increased recruitment of U2AF65 and PRP19C to the pre-mRNA
Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.
GeneRIF
Nashville, United States. In Plos One, 2010
New low abundance splicing factors connected to NTC (Nineteen Complex) function, provides evidence for distinct Prp19 containing complexes, and underscores the role of the Prp19 WD40 domain as a splicing scaffold.
Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia.
GeneRIF
Tokyo, Japan. In Exp Cell Res, 2010
hPRP19 interacts with PHD3 to suppress the cell death under hypoxic conditions by limiting the function of PHD3 which leads to caspase activation
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?
Review
Udine, Italy. In Mol Cell Biol, 2010
The new findings are as follows: (i) APE1 interacts with rRNA and ribosome processing protein NPM1 within the nucleolus; (ii) APE1 interacts with proteins involved in ribosome assembly (i.e., RLA0, RSSA) and RNA maturation (i.e., PRP19, MEP50) within the cytoplasm; (iii) APE1 cleaves abasic RNA; and (iv) APE1 cleaves a specific coding region of c-myc mRNA in vitro and influences c-myc mRNA level and half-life in cells.
Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae.
Review
Porto Alegre, Brazil. In Mutat Res, 2003
Of the seven DNA repair genes involved in induced mutagenesis three PSO loci [PSO1/REV3, PSO8/RAD6, PSO9/MEC3] were allelic to already known repair genes, whereas three, PSO2/SNM1, PSO3/RNR4, and PSO4/PRP19 represent new genes involved in DNA repair and nucleic acid metabolism in S. cerevisiae.
The Prp19p-associated complex in spliceosome activation.
Impact
Taiwan. In Science, 2003
During spliceosome activation, a large structural rearrangement occurs that involves the release of two small nuclear RNAs, U1 and U4, and the addition of a protein complex associated with Prp19p.
The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism.
Review
Frankfurt am Main, Germany. In Mutat Res, 2001
Four of these PSO loci were found allelic to already known repair genes, whereas two, PSO2 and PSO4, represent new genes involved in DNA repair and in repair/pre-mRNA processing in S. cerevisiae.
