Papers on
Prp19
Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA.Grillari et al., Vienna, Austria. In Plos One, 2011
Originally the novel protein Blom7α was identified as novel pre-mRNA splicing factor that interacts with SNEV(Prp19/Pso4), an essential protein involved in extension of human endothelial cell life span, DNA damage repair, the ubiquitin-proteasome system, and pre-mRNA splicing.
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Lee et al., Udine, Italy. In Mol Cell Biol, 2010
The new findings are as follows: (i) APE1 interacts with rRNA and ribosome processing protein NPM1 within the nucleolus; (ii) APE1 interacts with proteins involved in ribosome assembly (i.e., RLA0, RSSA) and RNA maturation (i.e., PRP19, MEP50) within the cytoplasm; (iii) APE1 cleaves abasic RNA; and (iv) APE1 cleaves a specific coding region of c-myc mRNA in vitro and influences c-myc mRNA level and half-life in cells.
Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae.Henriques et al., Porto Alegre, Brazil. In Mutat Res, 2003
Of the seven DNA repair genes involved in induced mutagenesis three PSO loci [PSO1/REV3, PSO8/RAD6, PSO9/MEC3] were allelic to already known repair genes, whereas three, PSO2/SNM1, PSO3/RNR4, and PSO4/PRP19 represent new genes involved in DNA repair and nucleic acid metabolism in S. cerevisiae.
The Prp19p-associated complex in spliceosome activation.Cheng et al., Taiwan. In Science, 2003
During spliceosome activation, a large structural rearrangement occurs that involves the release of two small nuclear RNAs, U1 and U4, and the addition of a protein complex associated with Prp19p.