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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CDC40 Cdc40p

PRP17, CDC40, SLU4, Cdc40p
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STEP, 9G8, PRP16, Prp19, CAN
Papers on PRP17
The spliceosomal PRP19 complex of trypanosomes.
Günzl et al., Farmington, United States. In Mol Microbiol, Mar 2015
We identified a complex that contained the core subunits PRP19, CDC5, PRL1, and SPF27, as well as PRP17, SKIP and PPIL1.
MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer.
Zhao et al., Changchun, China. In Iubmb Life, 2014
Bioinformatics analysis further deduced that CDC40 is a potential target of miR-378, and luciferase reporter assays confirmed the direct regulation of CDC40 by miR-378.
Context dependent splicing functions of Bud31/Ycr063w define its role in budding and cell cycle progression.
Vijayraghavan et al., Bengaluru, India. In Biochem Biophys Res Commun, 2012
Yeast PRP17, another NTC sub-complex member, is also required for G1-S and G2-M cell cycle transitions.
PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans.
Schedl et al., Saint Louis, United States. In Dev Dyn, 2010
PRP-17 is orthologous to the yeast and human pre-mRNA splicing factor PRP17/CDC40 and can rescue the temperature-sensitive lethality of yeast PRP17.
Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.
Půta et al., Praha, Czech Republic. In J Cell Biochem, 2009
Using a synthetic lethality screen, we found that prp45(1-169) genetically interacts with alleles of NTC members SYF1, CLF1/SYF3, NTC20, and CEF1, and 2nd step splicing factors SLU7, PRP17, PRP18, and PRP22.
The splicing factor Prp17 interacts with the U2, U5 and U6 snRNPs and associates with the spliceosome pre- and post-catalysis.
Vijayraghavan et al., Bengaluru, India. In Biochem J, 2009
Data show that Prp17 interacts with U2, U5 and U6 snRNPs (small nuclear ribonucleoproteins) but it is not a core component of any one snRNP.
A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.
Kupiec et al., Tel Aviv-Yafo, Israel. In Curr Genet, 2007
Mutants are hydroxyurea- and methylmethane sulfonate-sensitive due to their S-phase entry defect.
The Saccharomyces cerevisiae gene CDC40/PRP17 controls cell cycle progression through splicing of the ANC1 gene.
Kupiec et al., Tel Aviv-Yafo, Israel. In Nucleic Acids Res, 2003
Mutations in the CDC40/PRP17 gene cause cell cycle arrest at the G2/M stage.
Dependence of pre-mRNA introns on PRP17, a non-essential splicing factor: implications for efficient progression through cell cycle transitions.
Vijayraghavan et al., Bengaluru, India. In Nucleic Acids Res, 2003
Saccharomyces cerevisiae PRP17 (CDC40) encodes a second-step pre-mRNA splicing factor with a role in cell division.
Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.
Fu et al., San Diego, United States. In Rna, 2001
Here we report that SKY1, a SRPK family member in Saccharomyces cerevisiae, genetically interacts with PRP8 and PRP17/SLU4, both of which are involved in splice site selection during pre-mRNA splicing.
Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae.
Kupiec et al., Tel Aviv-Yafo, Israel. In Genetics, 2000
The PRP17/CDC40 gene of Saccharomyces cerevisiae functions in two different cellular processes: pre-mRNA splicing and cell cycle progression.
Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae.
Beggs et al., Edinburgh, United Kingdom. In Rna, 2000
Through a genetic screen to search for factors that interact with Prp17/Cdc40p, a protein involved in both cell cycle progression and pre-mRNA splicing, we identify three novel factors, which we call Syf1p, Syf2p, and Syf3 (SYnthetic lethal with cdc Forty).
The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.
Garcia-Blanco et al., Durham, United States. In Rna, 2000
Temperature-sensitive prp17 alleles with mutations of these four amino acids are defective for the second step of splicing and are synthetically lethal with a U5 snRNA loop I mutation, which is also required for the second step of splicing.
Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.
Kupiec et al., Tel Aviv-Yafo, Israel. In Genetics, 2000
It was found recently that PRP17 is identical to the cell division cycle CDC40 gene.
Single-strand scissions of nuclear yeast DNA occur without meiotic recombination.
Simchen et al., Jerusalem, Israel. In Curr Genet, 1980
Similar scissions in DNA are also found in a temperature-sensitive mutant (cdc40/cdc40), which does not undergo commitment to recombination at the restrictive temperature, and in vegetative wild type cells that were previously exposed to sporulation medium.
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