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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Prion protein

PrP, caspase-1, ICE, Caspase
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, caspase-3, V1a, IL-18, bcl-2
Papers using PrP antibodies
Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF)
Supplier
Blasiak Janusz et al., In Molecular Biology Reports, 2009
... ApoAlert Caspase Colorimetric Assay Kit was bought from Clontech Laboratories Inc (Palo Alto, ...
Subchronic oral toxicity of silver nanoparticles
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Su Hong-Lin et al., In International Journal of Nanomedicine, 2009
... The concentration of AgNP on NSP was determined by an atomic absorption spectrometer (iCE 3300; Thermo Scientific, Waltham, MA).
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Supplier
Das Gobardhan, In PLoS ONE, 2008
... Caspase-Glo™ 3/7 assay kit was acquired from Promega Corporation, Madison, WI, USA ...
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
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Mukhopadhyay Partha, In PLoS ONE, 2007
... , NF-κB (p65), IκB-α, and caspase-1 antibodies (Abs) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis.
Supplier
Khoury Joseph El, In PLoS ONE, 2006
... PrP-specific monoclonal antibody 8H4 (against residues 145 to 180) was obtained from Abcam (Cambridge, MA, USA) and ...
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Papers on PrP
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
New
Impact
Stehlik et al., Chicago, United States. In Nat Immunol, 30 Apr 2014
Subsequently, recruitment of the inflammasome adaptor ASC links ALRs to the activation of caspase-1.
Parameters that Affect Macromolecular Self-Assembly of Prion Protein.
New
Ryou et al., Lexington, United States. In Protein J, 27 Apr 2014
UNLABELLED: Amyloidogenesis of prion protein (PrP) is closely associated with the pathobiology of prion diseases.
Tuberculosis antigen-induced expression of IFN-α in tuberculosis patients inhibits production of IL-1β
New
Wu et al., Shiqi, China. In Faseb J, 27 Apr 2014
Notably, we showed that IFN-α inhibited production of IL-1β through 2 distinct mechanisms: IFN-α signaling, via the STAT1 transcription factor, suppressed caspase-1-dependent IL-1β maturation, and IFN-α induced the production of IL-10 in a STAT1-dependent manner in which IL-10 reduced the abundance of IL-1β.
Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.
Review
New
Horng, Boston, United States. In Trends Immunol, 16 Apr 2014
UNLABELLED: The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in sentinel cells of the innate immune system.
Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation.
New
Impact
Chen et al., Dallas, United States. In Cell, 13 Apr 2014
Furthermore, fibers of recombinant PYRIN can convert ASC into functional polymers capable of activating caspase-1.
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes.
New
Impact
Egelman et al., Boston, United States. In Cell, 13 Apr 2014
Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death.
A80: Skeletal Features of Neonatal-Onset Multisystem Inflammatory Disease (NOMID) on Anakinra Treatment: Long-Term Follow-up.
New
Hill et al., Bethesda, United States. In Arthritis Rheumatol, 31 Mar 2014
About 50% of patients with NOMID have de novo missense mutations in NLRP3/CIAS1, leading to constitutive inflammasome activation and IL-1 production in monocytes, and caspase-1 mediated persistence of osteoblast progenitor cells that are also found in other fibroblastoid tumors ().
Inflammasomes in the CNS.
Review
New
Impact
Power et al., Edmonton, Canada. In Nat Rev Neurosci, 28 Feb 2014
Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1β and interleukin-18, as well as pyroptotic cell death.
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
New
Impact
Greene et al., San Francisco, United States. In Nature, 23 Feb 2014
The remaining over 95% of quiescent lymphoid CD4 T cells die by caspase-1-mediated pyroptosis triggered by abortive viral infection.
The Impact of Autophagy on Cell Death Modalities.
Review
New
Choi et al., Boston, United States. In Int J Cell Biol, Dec 2013
Recent advances suggest that autophagy can dampen inflammatory responses, including inflammasome-dependent caspase-1 activation and maturation of proinflammatory cytokines.
Hijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearance.
Review
New
Mouillet-Richard et al., Paris, France. In Front Aging Neurosci, Dec 2013
The cellular prion protein PrP(c) is the normal counterpart of the scrapie prion protein PrP (Sc), the main component of the infectious agent of transmissible spongiform encephalopathies.
Decompensation of β -Cells in Diabetes: When Pancreatic β -Cells Are on ICE(R).
Review
New
Abderrahmani et al., Lille, France. In J Diabetes Res, Dec 2013
UNLABELLED: Insulin production and secretion are temporally regulated.
Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein.
New
Nishida et al., Nagasaki, Japan. In Sci Rep, Dec 2013
Prion diseases are neurodegenerative disorders characterized by the aggregation of abnormally folded prion protein (PrP(Sc)).
Modes of Retinal Cell Death in Diabetic Retinopathy.
New
Mohr et al., East Lansing, United States. In J Clin Exp Ophthalmol, Nov 2013
Diabetes leads to significant Müller cell loss at 7 months duration of diabetes in retinas of diabetic mice compared to non-diabetic, which is prevented by the inhibition of the caspase-1/IL-1β (interleukin-1beta) pathway using the IL-1 receptor knockout mouse.
Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function.
Review
New
Thenet et al., Paris, France. In Tissue Barriers, May 2013
UNLABELLED: The cellular prion protein was historically characterized owing to its misfolding in prion disease.
Cutting Edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor.
GeneRIF
Ohno et al., Japan. In J Immunol, 2012
orally infected B. abortus invades the host through M cells by using PrP(C) on the apical surface of M cells as an uptake receptor
The association between prion proteins and Aβ₁₋₄₂ oligomers in cytotoxicity and apoptosis.
GeneRIF
Kim et al., South Korea. In Biochem Biophys Res Commun, 2012
cells with abundant PrPC expression seemed to be more susceptible to Abeta(1-42) oligomer toxicity, suggesting the importance of the level of PrPC expression in the induction of apoptosis.
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions.
GeneRIF
Supattapone et al., United States. In Proc Natl Acad Sci U S A, 2012
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions
[A redox process of ethanethiol group increases formation of beta-sheet structure and amyloid fibrils of wild type human prion protein].
GeneRIF
Dong et al., Beijing, China. In Bing Du Xue Bao, 2012
the formation of the disulfide bridge induces the alteration of the secondary structure and enhances the progresses of aggregation and fibrillization of PrP protein.
Neuregulin-1 exerts protective effects against neurotoxicities induced by C-terminal fragments of APP via ErbB4 receptor.
GeneRIF
Woo et al., Seoul, South Korea. In J Pharmacol Sci, 2011
NRG1 attenuated the neurotoxicities induced by the expression of APP-CTs in neuronal cells.
More papers using PrP antibodies
Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells
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Teixeira Natércia A et al., In BMC Cell Biology, 2006
... Caspase-GloTM -3/7 luminometric assay was from Promega Corporation (Madison, WI, USA) and ...
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.
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Wölfl Stefan, In PLoS ONE, 2006
... Caspase substrate N-acteyl-Asp-Glu-Val-Asp-7-amino-4-methyl-coumarin (Ac-DEVD-AMC) and the pan-caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem (St ...
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway
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Rothwell Nancy J et al., In European Journal of Immunology, 2006
... The anti-mouse p10 caspase-1 antibody was from Santa Cruz Biotechnology.
COPs and POPs: modulators of inflammasome activity
Supplier
Magun Bruce et al., In Toxins, 2006
... MA), anti-ASC was purchased from Enzo Life Sciences (Lausen, Switzerland), and anti-p38, anti-cryopyrin (H-66)/NALP3, and anti-caspase-1 (M-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein.
Supplier
Westaway David, In PLoS Pathogens, 2006
... Insertion of the coding sequence of murine PrP containing a 3F4 epitope tag into pIRESneo (Clontech-Takara Bio Europe) and generation ...
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity
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Moore Darren J et al., In Molecular Neurodegeneration, 2006
... Adult hemizygous PrP-A53T-αSyn transgenic mice [ ...
The inflammasome: first line of the immune response to cell stress
Supplier
Ishibashi Hiromi et al., In Arthritis Research & Therapy, 2005
... Polyclonal anti-IL-1β, pro-IL-1β and anti-cleaved caspase-1 (D57A2) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Thymidylate synthase: a critical target in cancer therapy?
Supplier
Morawiec-Sztandera Alina et al., In Molecular Biology Reports, 2003
... ApoAlert Caspase Colorimetric Assay Kit was bought from Clontech Laboratories Inc (Palo Alto, ...
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis
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Nicotera Pierluigi et al., In The Journal of Cell Biology, 2002
... Caspase inhibitors zVAD-fmk, Ac-YVAD-chloromethylketone, and zD-cbk were obtained from Bachem.
Equine estrogens differentially prevent cell death induced by glutamate
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Bhavnani Bhagu R et al., In BMC Neuroscience, 2002
... Caspase inhibitors, Z-Val-Ala-DL-Asp (OMe)-fluoromethylketone (Z-VAD-fmk) and Z-Asp (OMe)-Glu (OMe)-Val-DL-Asp (OMe)- fluoromethylketone (Z-DEVD-fmk) were purchased from Bachem Bioscience Inc (King of ...
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing
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Nukina Nobuyuki et al., In The Journal of Cell Biology, 2001
... The following antibodies were used: anti-APP (22C11), anti-BACE1, and anti–Thy-1.1 (Millipore); anti-PrP (SAF-32; Cayman Chemical); anticalnexin, anti-GM130, anti-X11, ...
The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c
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Martin Seamus J. et al., In The Journal of Experimental Medicine, 1999
... anti–X-linked inhibitor of apoptosis protein (XIAP), anti-BRUCE, and anti-gelsolin antibodies were purchased from BD Biosciences; anti–caspase-1 rabbit polyclonal antibody was purchased from Santa Cruz Biotechnology, Inc.; anti–caspase-6 and anti–caspase-9 ...
Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro.
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Valdivia Raphael H., In PLoS Pathogens, 1998
... Caspase 1 inhibitors, YVAD and WEHD were purchased from Biovision and R&D systems, respectively ...
Gene expression during ER stress–induced apoptosis in neurons
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Prehn Jochen H.M. et al., In The Journal of Cell Biology, 1997
... Caspase substrate acetyl-DEVD-7-amido-4-methylcoumarin (Ac-DEVD-AMC) and the broad-spectrum caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem.
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
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Claesson Mogens H. et al., In The Journal of Cell Biology, 1996
... Ac-Y-V-A-D-chloromethylketone ICE inhibitor (N-1330) was from Bachem Bioscience (Heidelberg, Germany) ...
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
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Simon Hans-Uwe et al., In The Journal of Experimental Medicine, 1996
... The IL-1 converting enzyme (ICE) inhibitor II (N-acetyl-Tyr-Val-Ala-Asp-chloromethylketone; Ac-YVAD-cmk) was obtained from Bachem (Bubendorf, Switzerland) ...
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
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Kroemer Guido et al., In The Journal of Experimental Medicine, 1996
... (500 ng/ml; Immunotech, Marseille, France) in the presence or absence of the membrane-permeant–specific inhibitor of ICE, Ac-YVAD.cmk
Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins
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Zurzolo Chiara et al., In The Journal of Cell Biology, 1993
... αPLAP was purchased from Rockland; αGH was purchased from Biotrend GMBH; α-cmyc and α-SAF 32 αPrP were purchased from Cayman Chemical; and biotin, HRP-linked ...
Nitric oxide as a secretory product of mammalian cells
Supplier
Zeiher Andreas M. et al., In The Journal of Experimental Medicine, 1991
... ICE- and CPP32-substrates and inhibitors were delivered by Bachem (Heidelberg, Germany).
The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis.
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Lasmezas Corinne Ida, In PLoS ONE, 1990
These mice express human PrP under the regulation of the murine promoter sequences, and survive for the same lifespan as non-transgenic mice of ...
Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice
Supplier
Schubert David et al., In The Journal of Cell Biology, 1990
... Ac-YVAD-cmk, also known as ICE inhibitor II, was from both Calbiochem (La Jolla, CA) and Bachem California (Torrance, CA).
Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors
Supplier
Weissmann Charles, In PLoS Biology, 1989
... The corresponding EGFP-PrP constructs were engineered through conventional cloning procedures, by inserting leader cDNAs into the NheI/AgeI; and core and/or GPI-anchor cDNAs into the BglII/EcoRI sites of pEGFP-C1 (BD Biosciences Clontech) ...
Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1).
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Badley Andrew D., In PLoS ONE, 1988
... The CellTiter-Blue cell viability and the Caspase-Glo 3/7, 8 or 9 assays were purchased from Promega Corporation (Madison, WI, USA) ...
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