The pathogenic role of the inflammasome in neurodegenerative diseases.
Chapel Hill, United States. In J Neurochem, 27 Jul 2015
UNASSIGNED: The inflammasome is a large macromolecular complex that contains multiple copies of a receptor or sensor of pathogen-derived or damage-derived molecular patterns, pro-caspase-1 and an adaptor called ASC (apoptotic speck containing protein with a CARD), which results in caspase-1 maturation.
Inflammasome activation and function in liver disease.
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Worcester, United States. In Nat Rev Gastroenterol Hepatol, 09 Jul 2015
Inflammasomes are multiprotein complexes that can sense danger signals from damaged cells and pathogens and assemble to mediate caspase-1 activation, which proteolytically activates the cytokines IL-1β and IL-18.