Structural Mechanisms of Inflammasome Assembly.
Cambridge, United States. In Febs J, 29 Nov 2014
UNLABELLED: Inflammasomes are supramolecular signaling complexes that activate a subset of caspases known as inflammatory caspases such as caspase-1.
Structural mechanisms in NLR inflammasome signaling.
Los Angeles, United States. In Curr Opin Struct Biol, 05 Oct 2014
Once formed, oligomers of the NLR proteins NLRP3 or NLRC4 'recruit' the adaptor protein ASC and the effector caspase-1, whereby NLRC4 can also directly interact with caspase-1.
A test for Creutzfeldt-Jakob disease using nasal brushings.
Hamilton, United States. In N Engl J Med, 07 Sep 2014
A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease.
Alzheimer's disease and prion protein.
More papers using
Boston, United States. In Intractable Rare Dis Res, May 2013
The cellular prion protein (PrP(C)) has newly been identified as a cell surface receptor for Aβ oligomers.