Inflammasomes in the CNS.
Edmonton, Canada. In Nat Rev Neurosci, Feb 2014
Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1β and interleukin-18, as well as pyroptotic cell death.
The impact of autophagy on cell death modalities.
Boston, United States. In Int J Cell Biol, Dec 2013
Recent advances suggest that autophagy can dampen inflammatory responses, including inflammasome-dependent caspase-1 activation and maturation of proinflammatory cytokines.
Modes of Retinal Cell Death in Diabetic Retinopathy.
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East Lansing, United States. In J Clin Exp Ophthalmol, Nov 2013
Diabetes leads to significant Müller cell loss at 7 months duration of diabetes in retinas of diabetic mice compared to non-diabetic, which is prevented by the inhibition of the caspase-1/IL-1β (interleukin-1beta) pathway using the IL-1 receptor knockout mouse.