GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
PrP, caspase-1, ICE, Caspase
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from
Tang et al., Loma Linda, United States. In Ann Neurol, 23 Dec 2013
UNLABELLED: Objective: The NLRP3 (NALP3, Cryopyrin) inflammasome, a key component of the innate immune system, facilitates caspase-1 and Interleukin (IL)-1β processing, which amplifies the inflammatory response.
Vacca et al., Novara, Italy. In Liver Transpl, 23 Dec 2013
Portal vein blood flow was measured and blood samples were taken for transaminases, thiobarbituric acid reactive substances (TBARS) and gluthatione (GSH) determination, whereas liver biopsy samples were used for Bax, Caspase 9, Akt and endothelial NOS (eNOS) activation through Western blot.
Matikainen et al., Helsinki, Finland. In Hum Immunol, 20 Dec 2013
The inflammasome complex detects pathogens and different danger signals, and triggers cysteine protease caspase-1-dependent processing of pro-inflammatory cytokines IL-1β and IL-18 in dendritic cells and macrophages.
Dixit et al., Baton Rouge, United States. In Cell Metab, 01 Nov 2013
Consistent with the hypothesis that systemic low-grade inflammation promotes age-related degenerative changes, the deficient Nlrp3 inflammasome-mediated caspase-1 activity improved glycemic control and attenuated bone loss and thymic demise.
Schneider et al., Paris, France. In Nat Med, Sep 2013
α-secretase-mediated cleavage of amyloid precursor protein (APP) precludes formation of neurotoxic amyloid-β (Aβ) peptides, and α-cleavage of cellular prion protein (PrP(C)) prevents its conversion into misfolded, pathogenic prions (PrP(Sc)).
Mehal et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
The acute inflammatory response to biomaterials requires nucleotide-binding domain and leucine-rich repeat-containing 3 (Nlrp3), apoptosis-associated speck-like protein containing CARD (Asc), and caspase-1.
Tredici et al., Milano, Italy. In Muscle Nerve, 2011
The nerves of the PrP(C)-treated rats show typical cobalamin-deficient lesions, significantly decreased abnormal maximum nerve conduction velocity values, and significantly increased tumor necrosis factor-alpha levels.
Han et al., Beijing, China. In World J Gastroenterol, 2011
PrPc expression is associated with histological types and differentiation of gastric cancer cells, and might be a valuable marker in predicting the efficacy of chemotherapy and the prognosis of gastric cancer patients receiving chemotherapy.
... Caspase substrate N-acteyl-Asp-Glu-Val-Asp-7-amino-4-methyl-coumarin (Ac-DEVD-AMC) and the pan-caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem (St ...
... MA), anti-ASC was purchased from Enzo Life Sciences (Lausen, Switzerland), and anti-p38, anti-cryopyrin (H-66)/NALP3, and anti-caspase-1 (M-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Martin Seamus J. et al., In The Journal of Experimental Medicine, 1999
... anti–X-linked inhibitor of apoptosis protein (XIAP), anti-BRUCE, and anti-gelsolin antibodies were purchased from BD Biosciences; anti–caspase-1 rabbit polyclonal antibody was purchased from Santa Cruz Biotechnology, Inc.; anti–caspase-6 and anti–caspase-9 ...
... The corresponding EGFP-PrP constructs were engineered through conventional cloning procedures, by inserting leader cDNAs into the NheI/AgeI; and core and/or GPI-anchor cDNAs into the BglII/EcoRI sites of pEGFP-C1 (BD Biosciences Clontech) ...