GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
PrP, caspase-1, ICE, Caspase
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from
Fernandez-Borja et al., Amsterdam, Netherlands. In Bioarchitecture, Feb 2016
Here, we present our recent discovery concerning the novel role of the GPI-AP prion protein (PrP) in the regulation of β1 integrin-mediated monocyte adhesion, migration and shape polarization in the context of existing literature on GPI-AP-dependent regulation of integrins.
Aragno et al., Torino, Italy. In Oxid Med Cell Longev, Dec 2015
These effects were associated with an exacerbated overexpression of Nlrp3 inflammasome, resulting in marked caspase-1 activation and a compromised activation of the cardioprotective RISK/HIF-2α pathways.
Müller et al., Zürich, Switzerland. In Gut Microbes, Dec 2015
The ability of H. pylori to activate the inflammasome and caspase-1 in antigen-presenting and other cells, and the resulting processing and release of caspase-1-dependent cytokines, impacts both the immunomodulatory and pathogenic activities of H. pylori.
Kopitar-Jerala, Ljubljana, Slovenia. In Front Cell Neurosci, 2014
The increased caspase-11 gene expression and better pro- inflammatory caspase-1 and -11 activation determined in stefin B deficient bone marrow-derived macrophages resulted in enhanced non-canonical inflammasome activation.
... Caspase substrate N-acteyl-Asp-Glu-Val-Asp-7-amino-4-methyl-coumarin (Ac-DEVD-AMC) and the pan-caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem (St ...
... MA), anti-ASC was purchased from Enzo Life Sciences (Lausen, Switzerland), and anti-p38, anti-cryopyrin (H-66)/NALP3, and anti-caspase-1 (M-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Martin Seamus J. et al., In The Journal of Experimental Medicine, 1999
... anti–X-linked inhibitor of apoptosis protein (XIAP), anti-BRUCE, and anti-gelsolin antibodies were purchased from BD Biosciences; anti–caspase-1 rabbit polyclonal antibody was purchased from Santa Cruz Biotechnology, Inc.; anti–caspase-6 and anti–caspase-9 ...
... The corresponding EGFP-PrP constructs were engineered through conventional cloning procedures, by inserting leader cDNAs into the NheI/AgeI; and core and/or GPI-anchor cDNAs into the BglII/EcoRI sites of pEGFP-C1 (BD Biosciences Clontech) ...