A clear and present danger: inflammasomes DAMPing down disorders of pregnancy.
Derby, United Kingdom. In Hum Reprod Update, 17 Dec 2014
Inflammasomes are unique, intracellular, multiprotein assemblies that enable caspase-1 mediated proteolytic processing of the proinflammatory cytokine interleukin-1β, levels of which are elevated in some forms of preterm birth and maternal metabolic disorders.
Role of inflammasome activation in development and exacerbation of asthma.
Puch'ŏn, South Korea. In Asia Pac Allergy, 31 Oct 2014
In addition to caspase-1 activation, proteinase 3 and other protease from activated neutrophils directly cleave pro-IL-1β and pro-IL-18 to IL-1β and IL-18, which contribute to the phenotype of subsequent adaptive immune responses without inflammasome activation.
To develop with or without the prion protein.
More papers using
Jouy-le-Moutier, France. In Front Cell Dev Biol, Dec 2013
The deletion of the cellular form of the prion protein (PrP(C)) in mouse, goat, and cattle has no drastic phenotypic consequence.