Inflammasome control of viral infection.
Memphis, United States. In Curr Opin Virol, 12 Apr 2015
UNASSIGNED: The inflammasome is a caspase-1 containing complex that activates the proinflammatory cytokines IL-1β and IL-18 and results in the proinflammatory cell death known as pyroptosis.
[NLRP3 inflammasome and diabetes].
In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, Dec 2014
NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome can recognize the metabolic stress signals, and cause caspase-1 activation and interleukin-lp (IL-1p) production, and is closely related to diabetes development.
Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis.
Messina, Italy. In Mediators Inflamm, Dec 2014
The expression of p-JNK, p-ERK, TNF-α, HMGB-1, NF-κB, Ras, Rho, Caspase 3, Bcl-2, and Bax was evaluated in lung and liver samples; SP600125 improved survival, reduced CLP induced activation of JNK, NF-κB, TNF-α, and HMGB-1, inhibited proapoptotic pathway, preserved Bcl-2 expression, and reduced histologic damage in both lung and liver of septic mice.
Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer.
Kagoshima, Japan. In Peerj, Dec 2014
The survival rate was determined using the Kaplan-Meier survival test, and cell viability was assessed using cell viability imaging kit and the MTT assay, and activation of the cell apoptosis pathway (Phosphorylated adenosine monophosphate activated protein kinase (p-AMPK), Apoptosis-inducing factor (AIF) and Caspase 3) were characterized by western blots.
Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin.
More papers using
Nagoya, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
The mechanisms are wide-spectrum, including elevation of caspase-1 and IL-18 in the small intestine, enhancement of the cell killing activity of cytotoxic T and natural killer (NK) cells, and anti-inflammatory and anti-angiogenic effects.