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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Prion protein

PrP, caspase-1, ICE, Caspase
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, caspase-3, V1a, bcl-2, HAD
Papers using PrP antibodies
Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF)
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Blasiak Janusz et al., In Molecular Biology Reports, 2009
... ApoAlert Caspase Colorimetric Assay Kit was bought from Clontech Laboratories Inc (Palo Alto, ...
Subchronic oral toxicity of silver nanoparticles
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Su Hong-Lin et al., In International Journal of Nanomedicine, 2009
... The concentration of AgNP on NSP was determined by an atomic absorption spectrometer (iCE 3300; Thermo Scientific, Waltham, MA).
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
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Das Gobardhan, In PLoS ONE, 2008
... Caspase-Glo™ 3/7 assay kit was acquired from Promega Corporation, Madison, WI, USA ...
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
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Mukhopadhyay Partha, In PLoS ONE, 2007
... , NF-κB (p65), IκB-α, and caspase-1 antibodies (Abs) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis.
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Khoury Joseph El, In PLoS ONE, 2006
... PrP-specific monoclonal antibody 8H4 (against residues 145 to 180) was obtained from Abcam (Cambridge, MA, USA) and ...
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Papers on PrP
Structural Studies of Truncated Forms of the Prion Protein PrP.
New
Stubbs et al., Nashville, United States. In Biophys J, 24 Apr 2015
The insolubility and inherent disorder of prions have made their structures difficult to study, particularly in the case of the infectious form of the mammalian prion protein PrP.
Protein misfolding cyclic amplification (PMCA) induces the conversion of recombinant prion protein to PrP oligomers causing neuronal apoptosis.
New
Zhao et al., Beijing, China. In J Neurochem, 21 Apr 2015
UNASSIGNED: The formation of neurotoxic prion protein (PrP) oligomers is thought to be a key step in the development of prion diseases.
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
New
Impact
Broz et al., Basel, Switzerland. In Nat Immunol, 16 Apr 2015
UNASSIGNED: The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of the inflammatory cytokines interleukin 1β (IL-1β) and IL-18.
Inflammasome control of viral infection.
Review
New
Kanneganti et al., Memphis, United States. In Curr Opin Virol, 12 Apr 2015
UNASSIGNED: The inflammasome is a caspase-1 containing complex that activates the proinflammatory cytokines IL-1β and IL-18 and results in the proinflammatory cell death known as pyroptosis.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
New
Impact
Dixit et al., New Haven, United States. In Nat Med, 31 Mar 2015
BHB did not inhibit caspase-1 activation in response to pathogens that activate the NLR family, CARD domain containing 4 (NLRC4) or absent in melanoma 2 (AIM2) inflammasome and did not affect non-canonical caspase-11, inflammasome activation.
A RecA Protein Surface Required for Activation of DNA Polymerase V.
New
Cox et al., Bethesda, United States. In Plos Genet, 28 Feb 2015
The same RecA surface is not utilized in the RecA activation of the homologous and highly mutagenic RumA'2B polymerase encoded by the integrating-conjugative element (ICE) R391, indicating a lack of structural conservation between the two systems.
A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.
New
Impact
Ma et al., San Francisco, United States. In Immunity, 20 Feb 2015
In normal cells, A20 constitutively associates with caspase-1 and pro-IL-1β, and NLRP3 activation further promotes A20 recruitment to the inflammasome.
Molecular and genetic properties of tumors associated with local immune cytolytic activity.
New
Impact
Hacohen et al., Cambridge, United States. In Cell, 15 Feb 2015
We identified recurrently mutated genes that showed positive association with cytolytic activity, including beta-2-microglobulin (B2M), HLA-A, -B and -C and Caspase 8 (CASP8), highlighting loss of antigen presentation and blockade of extrinsic apoptosis as key strategies of resistance to cytolytic activity.
[Long noncoding RNA HOTAIR modulates the function of trophoblast cells in pre-eclampsia].
New
Sun et al., In Sichuan Da Xue Xue Bao Yi Xue Ban, Jan 2015
Western blot assay was applied to detect the expression level of apoptotic proteins Caspase-3 and BCL-2.
Inflammasome-Independent Regulation of IL-1-Family Cytokines.
New
Impact
Joosten et al., Nijmegen, Netherlands. In Annu Rev Immunol, Jan 2015
One such unique protease is caspase-1, which is activated by protein platforms called the inflammasomes.
Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.
Review
New
Fransén et al., Örebro, Sweden. In Mediators Inflamm, Dec 2014
The multimeric NLRP3 complex results in the caspase-1 activation and the release of potent inflammatory cytokines, like IL-1β.
Biochemical insight into the prion protein family.
Review
New
Rezaei et al., Jouy-le-Moutier, France. In Front Cell Dev Biol, Dec 2014
Finally, we questioned if prion protein family have conserved the PrP structural bistability, which should be at the origin of Prion phenomenon and if Prion pathology is not, ultimately, an exaptation of the physiological propensity of PrP to undergo a structural switch and polymerize.
Hepatocyte- Specific Deletion of ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) Results in Altered Fibrotic Gene Expression in the Thioacetamide Model of Liver Injury.
New
Gunton et al., Sydney, Australia. In Plos One, Dec 2014
There was no significant difference in hepatocyte apoptosis or proliferation, as assessed by cleaved Caspase-3 and Ki67 respectively.
Gut-liver axis: role of inflammasomes.
Review
Saraswat et al., India. In J Clin Exp Hepatol, 2013
They are involved in recognizing diverse microbial (bacteria, viruses, fungi and parasites), stress and damage signals, which result in direct activation of caspase-1, leading to secretion of potent pro-inflammatory cytokines and pyroptosis.
Cutting Edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor.
GeneRIF
Ohno et al., Japan. In J Immunol, 2012
orally infected B. abortus invades the host through M cells by using PrP(C) on the apical surface of M cells as an uptake receptor
The association between prion proteins and Aβ₁₋₄₂ oligomers in cytotoxicity and apoptosis.
GeneRIF
Kim et al., South Korea. In Biochem Biophys Res Commun, 2012
cells with abundant PrPC expression seemed to be more susceptible to Abeta(1-42) oligomer toxicity, suggesting the importance of the level of PrPC expression in the induction of apoptosis.
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions.
GeneRIF
Supattapone et al., United States. In Proc Natl Acad Sci U S A, 2012
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions
[A redox process of ethanethiol group increases formation of beta-sheet structure and amyloid fibrils of wild type human prion protein].
GeneRIF
Dong et al., Beijing, China. In Bing Du Xue Bao, 2012
the formation of the disulfide bridge induces the alteration of the secondary structure and enhances the progresses of aggregation and fibrillization of PrP protein.
Neuregulin-1 exerts protective effects against neurotoxicities induced by C-terminal fragments of APP via ErbB4 receptor.
GeneRIF
Woo et al., Seoul, South Korea. In J Pharmacol Sci, 2011
NRG1 attenuated the neurotoxicities induced by the expression of APP-CTs in neuronal cells.
Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin.
Review
Iigo et al., Nagoya, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
The mechanisms are wide-spectrum, including elevation of caspase-1 and IL-18 in the small intestine, enhancement of the cell killing activity of cytotoxic T and natural killer (NK) cells, and anti-inflammatory and anti-angiogenic effects.
More papers using PrP antibodies
Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells
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Teixeira Natércia A et al., In BMC Cell Biology, 2006
... Caspase-GloTM -3/7 luminometric assay was from Promega Corporation (Madison, WI, USA) and ...
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.
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Wölfl Stefan, In PLoS ONE, 2006
... Caspase substrate N-acteyl-Asp-Glu-Val-Asp-7-amino-4-methyl-coumarin (Ac-DEVD-AMC) and the pan-caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem (St ...
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway
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Rothwell Nancy J et al., In European Journal of Immunology, 2006
... The anti-mouse p10 caspase-1 antibody was from Santa Cruz Biotechnology.
COPs and POPs: modulators of inflammasome activity
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Magun Bruce et al., In Toxins, 2006
... MA), anti-ASC was purchased from Enzo Life Sciences (Lausen, Switzerland), and anti-p38, anti-cryopyrin (H-66)/NALP3, and anti-caspase-1 (M-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein.
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Westaway David, In PLoS Pathogens, 2006
... Insertion of the coding sequence of murine PrP containing a 3F4 epitope tag into pIRESneo (Clontech-Takara Bio Europe) and generation ...
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity
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Moore Darren J et al., In Molecular Neurodegeneration, 2006
... Adult hemizygous PrP-A53T-αSyn transgenic mice [ ...
The inflammasome: first line of the immune response to cell stress
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Ishibashi Hiromi et al., In Arthritis Research & Therapy, 2005
... Polyclonal anti-IL-1β, pro-IL-1β and anti-cleaved caspase-1 (D57A2) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Thymidylate synthase: a critical target in cancer therapy?
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Morawiec-Sztandera Alina et al., In Molecular Biology Reports, 2003
... ApoAlert Caspase Colorimetric Assay Kit was bought from Clontech Laboratories Inc (Palo Alto, ...
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis
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Nicotera Pierluigi et al., In The Journal of Cell Biology, 2002
... Caspase inhibitors zVAD-fmk, Ac-YVAD-chloromethylketone, and zD-cbk were obtained from Bachem.
Equine estrogens differentially prevent cell death induced by glutamate
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Bhavnani Bhagu R et al., In BMC Neuroscience, 2002
... Caspase inhibitors, Z-Val-Ala-DL-Asp (OMe)-fluoromethylketone (Z-VAD-fmk) and Z-Asp (OMe)-Glu (OMe)-Val-DL-Asp (OMe)- fluoromethylketone (Z-DEVD-fmk) were purchased from Bachem Bioscience Inc (King of ...
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing
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Nukina Nobuyuki et al., In The Journal of Cell Biology, 2001
... The following antibodies were used: anti-APP (22C11), anti-BACE1, and anti–Thy-1.1 (Millipore); anti-PrP (SAF-32; Cayman Chemical); anticalnexin, anti-GM130, anti-X11, ...
The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c
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Martin Seamus J. et al., In The Journal of Experimental Medicine, 1999
... anti–X-linked inhibitor of apoptosis protein (XIAP), anti-BRUCE, and anti-gelsolin antibodies were purchased from BD Biosciences; anti–caspase-1 rabbit polyclonal antibody was purchased from Santa Cruz Biotechnology, Inc.; anti–caspase-6 and anti–caspase-9 ...
Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro.
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Valdivia Raphael H., In PLoS Pathogens, 1998
... Caspase 1 inhibitors, YVAD and WEHD were purchased from Biovision and R&D systems, respectively ...
Gene expression during ER stress–induced apoptosis in neurons
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Prehn Jochen H.M. et al., In The Journal of Cell Biology, 1997
... Caspase substrate acetyl-DEVD-7-amido-4-methylcoumarin (Ac-DEVD-AMC) and the broad-spectrum caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem.
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
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Claesson Mogens H. et al., In The Journal of Cell Biology, 1996
... Ac-Y-V-A-D-chloromethylketone ICE inhibitor (N-1330) was from Bachem Bioscience (Heidelberg, Germany) ...
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
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Simon Hans-Uwe et al., In The Journal of Experimental Medicine, 1996
... The IL-1 converting enzyme (ICE) inhibitor II (N-acetyl-Tyr-Val-Ala-Asp-chloromethylketone; Ac-YVAD-cmk) was obtained from Bachem (Bubendorf, Switzerland) ...
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
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Kroemer Guido et al., In The Journal of Experimental Medicine, 1996
... (500 ng/ml; Immunotech, Marseille, France) in the presence or absence of the membrane-permeant–specific inhibitor of ICE, Ac-YVAD.cmk
Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins
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Zurzolo Chiara et al., In The Journal of Cell Biology, 1993
... αPLAP was purchased from Rockland; αGH was purchased from Biotrend GMBH; α-cmyc and α-SAF 32 αPrP were purchased from Cayman Chemical; and biotin, HRP-linked ...
Nitric oxide as a secretory product of mammalian cells
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Zeiher Andreas M. et al., In The Journal of Experimental Medicine, 1991
... ICE- and CPP32-substrates and inhibitors were delivered by Bachem (Heidelberg, Germany).
The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis.
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Lasmezas Corinne Ida, In PLoS ONE, 1990
These mice express human PrP under the regulation of the murine promoter sequences, and survive for the same lifespan as non-transgenic mice of ...
Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice
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Schubert David et al., In The Journal of Cell Biology, 1990
... Ac-YVAD-cmk, also known as ICE inhibitor II, was from both Calbiochem (La Jolla, CA) and Bachem California (Torrance, CA).
Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors
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Weissmann Charles, In PLoS Biology, 1989
... The corresponding EGFP-PrP constructs were engineered through conventional cloning procedures, by inserting leader cDNAs into the NheI/AgeI; and core and/or GPI-anchor cDNAs into the BglII/EcoRI sites of pEGFP-C1 (BD Biosciences Clontech) ...
Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1).
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Badley Andrew D., In PLoS ONE, 1988
... The CellTiter-Blue cell viability and the Caspase-Glo 3/7, 8 or 9 assays were purchased from Promega Corporation (Madison, WI, USA) ...
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