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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Prion protein

PrP, caspase-1, ICE, Caspase
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, caspase-3, V1a, bcl-2, HAD
Papers using PrP antibodies
Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF)
Supplier
Blasiak Janusz et al., In Molecular Biology Reports, 2009
... ApoAlert Caspase Colorimetric Assay Kit was bought from Clontech Laboratories Inc (Palo Alto, ...
Subchronic oral toxicity of silver nanoparticles
Supplier
Su Hong-Lin et al., In International Journal of Nanomedicine, 2009
... The concentration of AgNP on NSP was determined by an atomic absorption spectrometer (iCE 3300; Thermo Scientific, Waltham, MA).
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
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Das Gobardhan, In PLoS ONE, 2008
... Caspase-Glo™ 3/7 assay kit was acquired from Promega Corporation, Madison, WI, USA ...
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
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Mukhopadhyay Partha, In PLoS ONE, 2007
... , NF-κB (p65), IκB-α, and caspase-1 antibodies (Abs) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis.
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Khoury Joseph El, In PLoS ONE, 2006
... PrP-specific monoclonal antibody 8H4 (against residues 145 to 180) was obtained from Abcam (Cambridge, MA, USA) and ...
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Papers on PrP
Inflammasome-Independent Regulation of IL-1-Family Cytokines.
New
Impact
Joosten et al., Nijmegen, Netherlands. In Annu Rev Immunol, 10 Jan 2015
One such unique protease is caspase-1, which is activated by protein platforms called the inflammasomes.
Cadmium induced embryopathy: Nitric Oxide rescues teratogenic effects of Cadmium.
New
Chatterjee et al., Chennai, India. In Toxicol Sci, 08 Jan 2015
Cd also caused the down-regulation of FOXO1, and up-regulation of FOXO3a and Caspase 3 mediated apoptosis.
Recombinant Adeno-associated Virus-Delivered Hypoxia-inducible Stanniocalcin-1 Expression Effectively Inhibits Hypoxia-induced Cell Apoptosis in Cardiomyocytes.
New
Qin et al., Zhengzhou, China. In J Cardiovasc Pharmacol, 31 Dec 2014
Moreover, the proapoptotic protein Caspase-3 and anti-apoptotic protein Bcl-2, which were dysregulated by hypoxia, were reversed by AAV-HRE-STC-1 infection.
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
New
Impact
Ambati et al., Lexington, United States. In Science, 21 Dec 2014
Multiple approved and clinically relevant NRTIs prevented caspase-1 activation, the effector of the NLRP3 inflammasome, induced by Alu RNA.
The Inflammasome and Autoinflammatory Syndromes.
New
Impact
Latz et al., San Diego, United States. In Annu Rev Pathol, 19 Dec 2014
We discuss our understanding of how inflammasomes assemble to trigger caspase-1 activation and subsequent cytokine release, describe how genetic mutations in inflammasome-related genes lead to autoinflammatory syndromes, and review the contribution of inflammasome activation to various pathologies arising from metabolic dysfunction.
A clear and present danger: inflammasomes DAMPing down disorders of pregnancy.
Review
New
Hay et al., Derby, United Kingdom. In Hum Reprod Update, 17 Dec 2014
Inflammasomes are unique, intracellular, multiprotein assemblies that enable caspase-1 mediated proteolytic processing of the proinflammatory cytokine interleukin-1β, levels of which are elevated in some forms of preterm birth and maternal metabolic disorders.
Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens.
Review
New
Shenoy et al., London, United Kingdom. In Curr Opin Microbiol, 13 Dec 2014
UNLABELLED: Inflammasomes - molecular platforms for caspase-1 activation - have emerged as common hubs for a number of pathways that detect and respond to bacterial pathogens.
iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging.
New
Impact
Tessier-Lavigne et al., New York City, United States. In Cell, 06 Dec 2014
It also permitted imaging of single degenerating axons in adult brain and the first visualization of cleaved Caspase-3 in degenerating embryonic sensory axons in vivo, even single axons.
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair.
New
Impact
Chan et al., Worcester, United States. In Immunity, 16 Nov 2014
These effects were caused by impaired NF-κB subunit RelB and p50 activation and by impaired caspase 1-mediated processing of interleukin-1β (IL-1β).
Role of inflammasome activation in development and exacerbation of asthma.
Review
New
Park et al., Puch'ŏn, South Korea. In Asia Pac Allergy, Oct 2014
In addition to caspase-1 activation, proteinase 3 and other protease from activated neutrophils directly cleave pro-IL-1β and pro-IL-18 to IL-1β and IL-18, which contribute to the phenotype of subsequent adaptive immune responses without inflammasome activation.
Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model.
New
Serfaty et al., Bordeaux, France. In Muscles Ligaments Tendons J, Jul 2014
PURPOSE: the aim of our study was to assess the potential of combined intratendinous injection of an anti-angiogenic drug: bevacizumab (AA) and Platelet Rich Plasma (PRP) to treat tendinopathy in a murine model of patellar and Achilles tendinopathy, and to evaluate its local toxicity.
CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome.
New
Schmitt-Ulms et al., Toronto, Canada. In Plos One, Dec 2013
UNLABELLED: The molecular function of the cellular prion protein (PrPC) and the mechanism by which it may contribute to neurotoxicity in prion diseases and Alzheimer's disease are only partially understood.
To develop with or without the prion protein.
Review
New
Béringue et al., Jouy-le-Moutier, France. In Front Cell Dev Biol, Dec 2013
The deletion of the cellular form of the prion protein (PrP(C)) in mouse, goat, and cattle has no drastic phenotypic consequence.
Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells.
New
Lee et al., Pusan, South Korea. In Plos One, Dec 2013
UNLABELLED: Anticancer properties and mechanisms of mimulone (MML), C-geranylflavonoid isolated from the Paulownia tomentosa fruits, were firstly elucidated in this study.
Prions in Variably Protease-Sensitive Prionopathy: An Update.
Review
Pirisinu et al., Cleveland, United States. In Pathogens, 2012
UNLABELLED: Human prion diseases, including sporadic, familial, and acquired forms such as Creutzfeldt-Jakob disease (CJD), are caused by prions in which an abnormal prion protein (PrPSc) derived from its normal cellular isoform (PrPC) is the only known component.
Cutting Edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor.
GeneRIF
Ohno et al., Japan. In J Immunol, 2012
orally infected B. abortus invades the host through M cells by using PrP(C) on the apical surface of M cells as an uptake receptor
The association between prion proteins and Aβ₁₋₄₂ oligomers in cytotoxicity and apoptosis.
GeneRIF
Kim et al., South Korea. In Biochem Biophys Res Commun, 2012
cells with abundant PrPC expression seemed to be more susceptible to Abeta(1-42) oligomer toxicity, suggesting the importance of the level of PrPC expression in the induction of apoptosis.
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions.
GeneRIF
Supattapone et al., United States. In Proc Natl Acad Sci U S A, 2012
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions
[A redox process of ethanethiol group increases formation of beta-sheet structure and amyloid fibrils of wild type human prion protein].
GeneRIF
Dong et al., Beijing, China. In Bing Du Xue Bao, 2012
the formation of the disulfide bridge induces the alteration of the secondary structure and enhances the progresses of aggregation and fibrillization of PrP protein.
Neuregulin-1 exerts protective effects against neurotoxicities induced by C-terminal fragments of APP via ErbB4 receptor.
GeneRIF
Woo et al., Seoul, South Korea. In J Pharmacol Sci, 2011
NRG1 attenuated the neurotoxicities induced by the expression of APP-CTs in neuronal cells.
More papers using PrP antibodies
Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells
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Teixeira Natércia A et al., In BMC Cell Biology, 2006
... Caspase-GloTM -3/7 luminometric assay was from Promega Corporation (Madison, WI, USA) and ...
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.
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Wölfl Stefan, In PLoS ONE, 2006
... Caspase substrate N-acteyl-Asp-Glu-Val-Asp-7-amino-4-methyl-coumarin (Ac-DEVD-AMC) and the pan-caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem (St ...
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway
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Rothwell Nancy J et al., In European Journal of Immunology, 2006
... The anti-mouse p10 caspase-1 antibody was from Santa Cruz Biotechnology.
COPs and POPs: modulators of inflammasome activity
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Magun Bruce et al., In Toxins, 2006
... MA), anti-ASC was purchased from Enzo Life Sciences (Lausen, Switzerland), and anti-p38, anti-cryopyrin (H-66)/NALP3, and anti-caspase-1 (M-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein.
Supplier
Westaway David, In PLoS Pathogens, 2006
... Insertion of the coding sequence of murine PrP containing a 3F4 epitope tag into pIRESneo (Clontech-Takara Bio Europe) and generation ...
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity
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Moore Darren J et al., In Molecular Neurodegeneration, 2006
... Adult hemizygous PrP-A53T-αSyn transgenic mice [ ...
The inflammasome: first line of the immune response to cell stress
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Ishibashi Hiromi et al., In Arthritis Research & Therapy, 2005
... Polyclonal anti-IL-1β, pro-IL-1β and anti-cleaved caspase-1 (D57A2) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Thymidylate synthase: a critical target in cancer therapy?
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Morawiec-Sztandera Alina et al., In Molecular Biology Reports, 2003
... ApoAlert Caspase Colorimetric Assay Kit was bought from Clontech Laboratories Inc (Palo Alto, ...
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis
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Nicotera Pierluigi et al., In The Journal of Cell Biology, 2002
... Caspase inhibitors zVAD-fmk, Ac-YVAD-chloromethylketone, and zD-cbk were obtained from Bachem.
Equine estrogens differentially prevent cell death induced by glutamate
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Bhavnani Bhagu R et al., In BMC Neuroscience, 2002
... Caspase inhibitors, Z-Val-Ala-DL-Asp (OMe)-fluoromethylketone (Z-VAD-fmk) and Z-Asp (OMe)-Glu (OMe)-Val-DL-Asp (OMe)- fluoromethylketone (Z-DEVD-fmk) were purchased from Bachem Bioscience Inc (King of ...
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing
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Nukina Nobuyuki et al., In The Journal of Cell Biology, 2001
... The following antibodies were used: anti-APP (22C11), anti-BACE1, and anti–Thy-1.1 (Millipore); anti-PrP (SAF-32; Cayman Chemical); anticalnexin, anti-GM130, anti-X11, ...
The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c
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Martin Seamus J. et al., In The Journal of Experimental Medicine, 1999
... anti–X-linked inhibitor of apoptosis protein (XIAP), anti-BRUCE, and anti-gelsolin antibodies were purchased from BD Biosciences; anti–caspase-1 rabbit polyclonal antibody was purchased from Santa Cruz Biotechnology, Inc.; anti–caspase-6 and anti–caspase-9 ...
Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro.
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Valdivia Raphael H., In PLoS Pathogens, 1998
... Caspase 1 inhibitors, YVAD and WEHD were purchased from Biovision and R&D systems, respectively ...
Gene expression during ER stress–induced apoptosis in neurons
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Prehn Jochen H.M. et al., In The Journal of Cell Biology, 1997
... Caspase substrate acetyl-DEVD-7-amido-4-methylcoumarin (Ac-DEVD-AMC) and the broad-spectrum caspase inhibitor Z-Val-Ala-Asp(O-methyl)-fluoromethylketone (zVAD-fmk) were obtained from Bachem.
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
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Claesson Mogens H. et al., In The Journal of Cell Biology, 1996
... Ac-Y-V-A-D-chloromethylketone ICE inhibitor (N-1330) was from Bachem Bioscience (Heidelberg, Germany) ...
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
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Simon Hans-Uwe et al., In The Journal of Experimental Medicine, 1996
... The IL-1 converting enzyme (ICE) inhibitor II (N-acetyl-Tyr-Val-Ala-Asp-chloromethylketone; Ac-YVAD-cmk) was obtained from Bachem (Bubendorf, Switzerland) ...
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
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Kroemer Guido et al., In The Journal of Experimental Medicine, 1996
... (500 ng/ml; Immunotech, Marseille, France) in the presence or absence of the membrane-permeant–specific inhibitor of ICE, Ac-YVAD.cmk
Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins
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Zurzolo Chiara et al., In The Journal of Cell Biology, 1993
... αPLAP was purchased from Rockland; αGH was purchased from Biotrend GMBH; α-cmyc and α-SAF 32 αPrP were purchased from Cayman Chemical; and biotin, HRP-linked ...
Nitric oxide as a secretory product of mammalian cells
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Zeiher Andreas M. et al., In The Journal of Experimental Medicine, 1991
... ICE- and CPP32-substrates and inhibitors were delivered by Bachem (Heidelberg, Germany).
The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis.
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Lasmezas Corinne Ida, In PLoS ONE, 1990
These mice express human PrP under the regulation of the murine promoter sequences, and survive for the same lifespan as non-transgenic mice of ...
Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice
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Schubert David et al., In The Journal of Cell Biology, 1990
... Ac-YVAD-cmk, also known as ICE inhibitor II, was from both Calbiochem (La Jolla, CA) and Bachem California (Torrance, CA).
Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors
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Weissmann Charles, In PLoS Biology, 1989
... The corresponding EGFP-PrP constructs were engineered through conventional cloning procedures, by inserting leader cDNAs into the NheI/AgeI; and core and/or GPI-anchor cDNAs into the BglII/EcoRI sites of pEGFP-C1 (BD Biosciences Clontech) ...
Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1).
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Badley Andrew D., In PLoS ONE, 1988
... The CellTiter-Blue cell viability and the Caspase-Glo 3/7, 8 or 9 assays were purchased from Promega Corporation (Madison, WI, USA) ...
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