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Protocadherin 11 X-linked

Protocadherins, PCDHX, PCDH11X, PCDHY, Protocadherin-PC, PCDH11Y, Protocadherin X
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with variable cytoplasmic domains. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, CAN, HAD, ACID, PAPC
Papers on Protocadherins
Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.
New
Jazin et al., Uppsala, Sweden. In Biol Sex Differ, Dec 2015
PCDH11Y and NLGN4Y are of special interest because they belong to gene families involved in cell fate determination and formation of dendrites and axon.
Protocadherins control the modular assembly of neuronal columns in the zebrafish optic tectum.
New
Jontes et al., Madison, United States. In J Cell Biol, Dec 2015
δ-Protocadherins comprise a family of neural adhesion molecules that are differentially expressed and have been implicated in a range of neurodevelopmental disorders.
Cyclostomes Lack Clustered Protocadherins.
New
Venkatesh et al., Singapore, Singapore. In Mol Biol Evol, Dec 2015
In jawed vertebrates, clustered protocadherins provide the molecular basis for this neuronal diversity, through stochastic and combinatorial expression of their various isoforms in individual neurons.
Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.
New
Gaudet et al., Cambridge, United States. In Structure, Dec 2015
Clustered protocadherin (Pcdh) proteins mediate dendritic self-avoidance in neurons via specific homophilic interactions in their extracellular cadherin (EC) domains.
DDX3Y, a Male-Specific Region of Y Chromosome Gene, May Modulate Neuronal Differentiation.
New
Salekdeh et al., Tehrān, Iran. In J Proteome Res, Oct 2015
The expression level of 12 Y-linked genes significantly increased over neural differentiation, including RBMY1, EIF1AY, DDX3Y, HSFY1, BPY2, PCDH11Y, UTY, RPS4Y1, USP9Y, SRY, PRY, and ZFY.
Protocadherins and hypothalamic development: do they play an unappreciated role?
Review
New
Kurrasch et al., Calgary, Canada. In J Neuroendocrinol, Jun 2015
In the present review, we focus on protocadherins, which form the largest subfamily of the cadherin superfamily and mediate homophilic cell-cell adhesion in the developing brain.
Emerging roles of protocadherins: from self-avoidance to enhancement of motility.
Review
New
Takeichi et al., Kōbe, Japan. In J Cell Sci, May 2015
Protocadherins are a group of transmembrane proteins belonging to the cadherin superfamily that are subgrouped into 'clustered' and 'non-clustered' protocadherins.
Protocadherins branch out: Multiple roles in dendrite development.
Review
Weiner et al., Iowa City, United States. In Cell Adh Migr, 2014
Protocadherins (Pcdhs) make up the largest group within this superfamily, encompassing over 80 genes, including the ∼60 genes of the α-, β-, and γ-Pcdh gene clusters and the non-clustered δ-Pcdh genes.
Detection of Selection Signatures on the X Chromosome in Three Sheep Breeds.
Du et al., Beijing, China. In Int J Mol Sci, 2014
We also identified some selection regions harboring genes that had human orthologs, including BKT, CENPI, GUCY2F, MSN, PCDH11X, PLP1, VSIG4, PAK3, WAS, PCDH19, PDHA1, and SRPX2.
Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
Shen et al., Changsha, China. In Plos One, 2014
Risk SNPs included rs9331888 (CLU), rs6691117 (CR1), rs4938933 (MS4A), rs9349407 (CD2AP), rs1160985 (TOMM40), rs4945261 (GAB2) and rs5984894 (PCDH11X); Protective SNPs consisted of rs744373 (BIN1), rs1562990 (MS4A), rs597668 (EXOC3L2), rs9271192 (HLA-DRB5/DRB1), rs157581 and rs11556505 (TOMM40).
Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.
Burlacu et al., Romania. In Toxicol Lett, 2014
The up-regulation of CD97 gene and the down-regulation of tumour suppressor genes (DKK-1, PCDH11X and TC531386) demonstrates the carcinogenic potential of ZEA.
Protocadherins in neurological diseases.
Review
Yagi et al., In Adv Neurobiol, 2013
Cadherins were originally isolated as calcium-dependent cell adhesion molecules and are characterized by their cadherin motifs in the extracellular domain.
Delta-protocadherins in health and disease.
Review
van Roy et al., Gent, Belgium. In Prog Mol Biol Transl Sci, 2012
The nonclustered genes encode mainly δ-protocadherins, which deviate markedly from classical cadherins.
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.
Impact
Sanes et al., Cambridge, United States. In Nature, 2012
Here we demonstrate roles for the clustered protocadherins (Pcdhs) in dendritic self-avoidance and self/non-self discrimination.
Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.
GeneRIF
Coto et al., Oviedo, Spain. In Brain Res, 2011
Our data...extended the lack of association of late-onset Alzheimer's disease to common PCDH11Y variants.
PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility.
GeneRIF
Pericak-Vance et al., Miami, United States. In Psychiatr Genet, 2010
An association between late-onset Alzheimer disease and the PCDH11X polymorphisms, was not detected.
Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population.
GeneRIF
Tan et al., Qingdao, China. In Brain Res, 2010
PCDH11X gene polymorphism does not play a major role in the genetic predisposition to late-onset Alzheimer disease in this Han Chinese population.
Quantitative analysis of alternative transcripts of human PCDH11X/Y genes.
GeneRIF
Kim et al., Pusan, South Korea. In Am J Med Genet B Neuropsychiatr Genet, 2010
The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes.
Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
GeneRIF
Franceschi et al., London, United Kingdom. In J Alzheimers Dis, 2009
association not found for rs5984894 polymorphism in PCDH11X in Alzheimer's disease in Italy
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
Impact
GeneRIF
Younkin et al., Jacksonville, United States. In Nat Genet, 2009
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
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