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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protocadherin 1

Protocadherin, protocadherin-1, PCDH1, E-cadherin-like, Cadherin-like, PC42
This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherins, PCDH17, PCDH10, PAPC, CAN
Papers on Protocadherin
Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Honig et al., New York City, United States. In Cell, Nov 2015
Self-avoidance, a process preventing interactions of axons and dendrites from the same neuron during development, is mediated in vertebrates through the stochastic single-neuron expression of clustered protocadherin protein isoforms.
Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription.
Nawijn et al., Groningen, Netherlands. In Am J Physiol Lung Cell Mol Physiol, Nov 2015
Genetic studies have identified Protocadherin-1 (PCDH1) and Mothers against decapentaplegic homolog-3 (SMAD3) as susceptibility genes for asthma.
Characterizing PCDH19 in human induced pluripotent stem cells (iPSCs) and iPSC-derived developing neurons: emerging role of a protein involved in controlling polarity during neurogenesis.
Terracciano et al., Roma, Italy. In Oncotarget, Oct 2015
PCDH19 (Protocadherin 19), a member of the cadherin superfamily, is involved in the pathogenic mechanism of an X-linked model of neurological disease.
Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency.
Gecz et al., Adelaide, Australia. In Hum Mol Genet, Oct 2015
Protocadherin 19 (PCDH19) female limited epilepsy (PCDH19-FE; also known as epilepsy and mental retardation limited to females, EFMR; MIM300088) is an infantile onset epilepsy syndrome with or without intellectual disability (ID) and autism.
Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization.
Weiner et al., Iowa City, United States. In J Biol Chem, Sep 2015
The γ-protocadherins (γ-Pcdhs) are a family of 22 adhesion molecules with multiple critical developmental functions, including the proper formation of dendritic arbors by forebrain neurons.
Novel mutation located in EC7 domain of protocadherin-15 uncovered by targeted massively parallel sequencing in a family segregating non-syndromic deafness DFNB23.
Jiang et al., Guangzhou, China. In Int J Pediatr Otorhinolaryngol, Jul 2015
The in-frame mutation c.2367_2369delTGT is located in the evolutionarily conserved EC7 domain of Protocadherin-15 and was predicted to be pathogenic.
Emerging roles of protocadherins: from self-avoidance to enhancement of motility.
Takeichi et al., Kōbe, Japan. In J Cell Sci, May 2015
Combinatorial expression of clustered protocadherin isoforms creates a great diversity of adhesive specificity for cells, and this process is likely to underlie the dendritic self-avoidance.
Epigenetic-Mediated Downregulation of μ-Protocadherin in Colorectal Tumours.
Siedlecki et al., Warsaw, Poland. In Gastroenterol Res Pract, 2014
Mucin-like protocadherin is implicated in intercellular adhesion and its expression was found decreased in colorectal cancer (CRC).
NF-Protocadherin Regulates Retinal Ganglion Cell Axon Behaviour in the Developing Visual System.
Piper et al., Cambridge, United Kingdom. In Plos One, 2014
NF-protocadherin (NFPC), a member of the non-clustered protocadherin family, has been shown to regulate retinal ganglion cell (RGC) axon and dendrite initiation, as well as influencing axonal navigation within the mid-optic tract.
Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function.
Sanes et al., Cambridge, United States. In Elife, 2014
Dendritic and axonal arbors of many neuronal types exhibit self-avoidance, in which branches repel each other.
Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function.
Hashimoto et al., Tokyo, Japan. In Bmc Pulm Med, 2014
We investigated the influence of protocadherin-1 (PCDH1), a susceptibility gene for bronchial hyperresponsiveness, on airway epithelial barrier function.
Genetic testing of epileptic encephalopathies of infancy: an approach.
Prasad et al., New Delhi, India. In Can J Neurol Sci, 2013
The recently described genes include; Cyclin-Dependent Kinase-Like 5 gene (CDKL5), Protocadherin 19 (PCDH19), Sodium channel neuronal type 1a subunit gene (SCN1A), Aristaless-Related Homeobox Gene (ARX), and Syntaxin binding protein 1 gene (STXBP1), amongst others.
Delta-protocadherins in health and disease.
van Roy et al., Gent, Belgium. In Prog Mol Biol Transl Sci, 2012
They can be subdivided phylogenetically into δ0-protocadherins (protocadherin-20), δ1-protocadherins (protocadherin-1, -7, -9, and -11X/Y), and δ2-protocadherins (protocadherin-8, -10, -17, -18, and -19).
Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts.
Koppelman et al., Groningen, Netherlands. In Pediatr Allergy Immunol, 2012
PCDH1 gene variant IVS3-116 associates with eczema in two independent birth cohorts in Netherlands.
Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.
Koppelman et al., Groningen, Netherlands. In Faseb J, 2012
PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains; enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells.
Non-clustered protocadherin.
Kim et al., Seoul, South Korea. In Cell Adh Migr, 2011
The phylogenetic analysis with full sequences of non-clustered PCDHs enabled them to be further classified into three subgroups: δ1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), δ2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and ε (PCDH15, PCDH16, PCDH21 and MUCDHL).
Pediatric genitourinary tumors.
Buckley et al., Winston-Salem, United States. In Curr Opin Oncol, 2010
Protocadherin gene clusters on chromosome 5q31 may act as tumor suppressors.
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
Postma et al., Groningen, Netherlands. In Am J Respir Crit Care Med, 2009
PCDH1 is a novel gene for BHR in adults and children. Its identification as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium and contributes to the development of BHR.
Expression of protocadherin-1 (Pcdh1) during mouse development.
Van Roy et al., Jena, Germany. In Dev Dyn, 2008
The tight spatial and temporal regulation of Pcdh1 expression suggests that this protocadherin plays multiple roles not only during development but also in mature tissues and organs in the mouse.
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