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Cadherin-related family member 2

protocadherin LKC
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: Protocadherin, Protocadherins, RhoC, POLYMERASE, MAST205
Papers on protocadherin LKC
Protocadherin of the liver, kidney, and colon associates with detergent-resistant membranes during cellular differentiation.
Naim et al., Hannover, Germany. In J Biol Chem, 2010
Protocadherin LKC (PLKC) is a member of the heterogeneous subgroup of protocadherins that was identified and described as a potential tumor-suppressor gene involved in contact inhibition (Okazaki, N., Takahashi, N., Kojima, S., Masuho, Y., and Koga, H. (2002) Carcinogenesis 23, 1139-1148 and Ose, R., Yanagawa, T., Ikeda, S., Ohara, O., and Koga, H. (2009) Mol.
Identification of gene expression profiling in hepatocellular carcinoma using cDNA microarrays.
Yang et al., Changsha, China. In Dig Dis Sci, 2009
The mRNA expression levels of RhoC and protocadherin LKC detected by reverse transcription polymerase chain reaction (RT-PCR) were consistent with the microarray experiment.
PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling.
GeneRIF
Koga et al., Kisarazu, Japan. In Mol Oncol, 2009
suppression of beta-catenin signaling by PCDH24 leads to contact inhibition
Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.
Huang et al., Changsha, China. In World J Gastroenterol, 2005
In addition, the expression of RhoC and protocadherin LKC was also detected with the reverse transcriptase polymerase chain reaction (RT-PCR) method.
Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
Koga et al., Kisarazu, Japan. In Carcinogenesis, 2002
The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.
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