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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prothymosin, alpha

Prothymosin alpha, Thymosin alpha 1
Top mentioned proteins: Alpha-1, ACID, CAN, HAD, Interleukin-2
Papers on Prothymosin alpha
Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion.
Maeda et al., Nagasaki, Japan. In Neuroscience, Feb 2016
UNASSIGNED: Prothymosin alpha (ProTα) has robustness roles against brain and retinal ischemia or serum-starvation stress.
Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively.
Sun et al., Qingdao, China. In Dev Comp Immunol, Nov 2015
Prothymosin alpha (ProTα) is a small protein that in mammals is known to participate in diverse biological processes including immunomodulation.
Prothymosin alpha expression and localization during the spermatogenesis of Danio rerio.
Minucci et al., Napoli, Italy. In Zygote, Nov 2015
UNASSIGNED: Prothymosin α (PTMA) is a highly acidic, intrinsically disordered protein, which is widely expressed and conserved throughout evolution; its uncommon features are reflected by its involvement in a variety of processes, including chromatin remodelling, transcriptional regulation, cell proliferation and death, immunity.
A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects.
Zheng et al., Nanjing, China. In Apoptosis, Oct 2015
Thymosin alpha 1 (Tα1) is commonly used for treating several diseases; however its usage has been limited because of poor penetration of the target tissue, such as tumor cells.
Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway.
Liu et al., Xi'an, China. In Apoptosis, Aug 2015
Thymosin alpha 1 (Tα1), an immunoactive peptide, has been shown to inhibit cell proliferation and induce apoptosis in human leukemia, non-small cell lung cancer, melanoma, and other human cancers.
Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.).
Guo et al., Wuhan, China. In Dev Comp Immunol, May 2015
Prothymosin alpha (ProTα) and thymosin beta (Tβ) belong to thymosin family, which consists of a series of highly conserved peptides involved in stimulating immune responses.
Thymosin alpha1 based immunomodulatory therapy for sepsis: a systematic review and meta-analysis.
Jin et al., Xi'an, China. In Int J Infect Dis, Apr 2015
OBJECTIVES: Thymosin alpha1 (Tα1) is considered a promising immunomodulatory drug.
Expression of prothymosin alpha predicts early recurrence and poor prognosis of hepatocellular carcinoma.
Park et al., Seoul, South Korea. In Hepatobiliary Pancreat Dis Int, Apr 2015
BACKGROUND: Prothymosin alpha (PTMA) is a nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation.
Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis.
Chao et al., Anyang, China. In Biochem Pharmacol, 2015
Prothymosin alpha (PTMA) is overexpressed in various human tumors, including hepatocellular carcinoma (HCC).
Specific in vitro binding of a new (99m)Tc-radiolabeled derivative of the C-terminal decapeptide of prothymosin alpha on human neutrophils.
Livaniou et al., Athens, Greece. In Int J Pharm, 2014
Prothymosin alpha (ProTα) is a conserved mammalian polypeptide with intracellular functions associated with cell proliferation and apoptosis and an extracellular role associated with immunopotentiation.
Preliminary methylation analysis of prothymosin α genomic sequences.
Gómez-Márquez et al., Santiago de Compostela, Spain. In Biochem Cell Biol, 2012
The decrease of ProTalpha mRNA during differentiation was not accompanied by changes in the methylation status
Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy.
Tsitsilonis et al., Athens, Greece. In Cancer Immunol Immunother, 2012
The thymus is a central lymphoid organ with crucial role in generating T cells and maintaining homeostasis of the immune system.
Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.
Wang et al., United States. In J Biol Chem, 2012
when added to cultured cells expressing mHtt, the purified recombinant ProTalpha protein not only entered the cells but it also significantly suppressed the mHtt-caused cytotoxicity.
[Prothymosin alpha interacts with C-terminal domain of histone H1 and dissociates p53-histone H1 complex].
Efstaf'eva et al., In Mol Biol (mosk), 2011
These results are consistent with the model that ProTa may enhance p53 transcription activity by displacement of histone H1 from p53-H1 repressive complex.
MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells.
Lin et al., Taipei, Taiwan. In J Biomed Sci, 2010
The prothymosin alpha is one of miR-1 target genes which involve in miR-1 inducing apoptosis
Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response.
Choy et al., London, Canada. In Plos One, 2010
Findings suggest that the binding of prothymosin alpha (ProTalpha) and Neh2 to Keap1 occurs synergistically via preformed structural elements.
Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma.
Thymosin Melanoma Investigation Group et al., Siena, Italy. In J Clin Oncol, 2010
PURPOSE: Thymosin alpha 1 (Talpha1) is an immunomodulatory polypeptide that enhances effector T-cell responses.
Preclinical studies with IRX-2 and thymosin alpha1 in combination therapy.
Hadden et al., United States. In Ann N Y Acad Sci, 2010
Thymosin alpha1 (Talpha1) is a 28 amino acid biologically active protein with pleiotropic immune enhancing activity.
Thymosin alpha1 to harness immunity to pathogens after haploidentical hematopoietic transplantation.
Velardi et al., Perugia, Italy. In Ann N Y Acad Sci, 2010
We designed a phase I/II clinical study to determine safety and efficacy of thymosin alpha1 (Talpha1) administration in recipients of one HLA haplotype (haploidentical) stem cell transplants for hematologic malignancies.
Thymosin alpha 1 for treatment of hepatitis C virus: promise and proof.
Sherman, Cincinnati, United States. In Ann N Y Acad Sci, 2010
Thymosin alpha 1 (Talpha1; TA-1) is an immunomodulatory peptide with intrinsic activities that might improve treatment outcomes for HCV by incorporation of this agent in current treatment paradigms.
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