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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein S

proteins A, PROS1, PROS, a protein S
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: SP-A, SP-D, CAN, HAD, ACID
Papers on proteins A
Differentiation of Urine-Derived Human Induced Pluripotent Stem Cells to Alveolar Type II Epithelial Cells.
Chen et al., Beijing, China. In Cell Reprogram, Jan 2016
These cells have phenotypic properties similar to mature human AT II cells, such as outstretched and epithelium-like morphology and the specific expression markers of AT II cells (surfactant proteins A, B, and C).
Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms.
Calkovska et al., Bratislava, Slovakia. In Pediatr Res, Jan 2016
A possible role of lung collectins, surfactant proteins A and D, which can exert both pro- and anti-inflammatory reactions, is discussed.
Role of High-mobility Group Protein A Isoforms and Their Clinicopathologic Significance in Primary Retinoblastoma.
Kashyap et al., New Delhi, India. In Appl Immunohistochem Mol Morphol, Jan 2016
BACKGROUND: High-mobility group proteins A (HMGA) are more abundant in rapidly dividing and transformed cells.
The roles of TAM receptor tyrosine kinases in the mammalian testis and immunoprivileged sites.
Han et al., Beijing, China. In Front Biosci, Dec 2015
TAM receptors have two common ligands, namely, growth arrest specific gene 6 (Gas6) and protein S (ProS).
Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.
Kuwano et al., Maebashi, Japan. In Cancer Sci, Dec 2015
We therefore investigated the expression of the NKG2D receptor and its ligands MHC class I chain-related proteins A and B (MICA/B), unique long 16 binding protein (ULBP) 1, and ULBP2/5/6 in resected specimens from 82 patients with EHCC.
Homeodomain proteins: an update.
Affolter et al., Basel, Switzerland. In Chromosoma, Nov 2015
In animals, there are 16 major classes, ANTP, PRD, PRD-LIKE, POU, HNF, CUT (with four subclasses: ONECUT, CUX, SATB, and CMP), LIM, ZF, CERS, PROS, SIX/SO, plus the TALE superclass with the classes IRO, MKX, TGIF, PBC, and MEIS.
Alzheimer's Disease: A Heme-Aβ Perspective.
Ghosh Dey et al., Calcutta, India. In Acc Chem Res, Oct 2015
Redox active iron is utilized in biology for various electron transfer and catalytic reactions essential for life, yet this same chemistry mediates the formation of partially reduced oxygen species (PROS).
Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.
Beers et al., Ōita, Japan. In Am J Physiol Lung Cell Mol Physiol, Oct 2015
Drawing on data generated from a variety of model systems expressing disease-related surfactant component mutations [surfactant proteins A and C (SP-A and SP-C); the lipid transporter ABCA3], this review will examine the concept of epithelial dysfunction in fibrotic lung disease, provide an update on AT2 cell and surfactant biology, summarize cellular responses to mutant surfactant components [including endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and intrinsic apoptosis], and examine quality control pathways (unfolded protein response, the ubiquitin-proteasome system, macroautophagy) that can be utilized to restore AT2 homeostasis.
Genetic determinants of tissue factor pathway inhibitor plasma levels.
Gagnon et al., Toronto, Canada. In Thromb Haemost, Aug 2015
The narrative summary included 6 genes and genetic variants (P151L mutation in TFPI, PROS1, F5, APOE, GLA, and V617F mutation in JAK2) as well as a genome-wide linkage study, and suggested future research directions.
Three toxic gases meet in the mitochondria.
Collman et al., Dijon, France. In Front Physiol, 2014
This model contains all three redox-active components in CcO's active site, which are required to minimize the production of partially-reduced-oxygen-species (PROS): Fe-heme ("heme a3") in a myoglobin-like model fitted with a proximal imidazole ligand, and a distal tris-imidazole Copper ("CuB") complex, where one imidazole is cross-linked to a phenol (mimicking "Tyr244").
TAM receptor signaling in immune homeostasis.
Ghosh et al., In Annu Rev Immunol, 2014
The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation.
Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging.
Giles-Komar et al., Easton, United States. In Plos One, 2014
The agonistic impact of these antibodies on efferocytosis could be demonstrated without addition of either of the MerTK ligands, Gas6 or ProS.
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
Rothlin et al., New Haven, United States. In Immunity, 2013
T cells, once activated, produced Protein S (Pros1) that signaled through TAM receptor tyrosine kinases in DCs to limit the magnitude of DC activation.
Small and large PROS1 deletions but no other types of rearrangements detected in patients with protein S deficiency.
Halldén et al., Kristianstad, Sweden. In Thromb Haemost, 2012
mutation deletions but no other types of rearrangements detected in patients with protein S deficiency
Non-severe allergic asthma is associated with elevated plasma protein C and protein S.
Okumura et al., In Thromb Haemost, 2012
Letter: non-severe allergic asthma is associated with elevated plasma protein C and protein S.
PROS1 Heerlen polymorphism is associated with increased free plasma tissue factor pathway inhibitor levels.
Mulder et al., In Thromb Haemost, 2012
genetic polymorphism is associated with increased free plasma tissue factor pathway inhibitor levels
Platelet-mediated proteolytic down regulation of the anticoagulant activity of protein S in individuals with haematological malignancies.
Brinkman et al., Amsterdam, Netherlands. In Thromb Haemost, 2012
proteolytic cleavage is increased in patients with essential thrombocythaemia and reduced in patients with chemotherapy-induced thrombocytopenia
Genotype and laboratory and clinical phenotypes of protein s deficiency.
Spannagl et al., München, Germany. In Am J Clin Pathol, 2012
Persistently low protein S activity levels are highly indicative of a genetic alteration in PROS1.
Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers.
Wiseman et al., Vancouver, Canada. In J Clin Oncol, 2006
A review of the top 12 candidates revealed well known thyroid cancer markers such as MET, TFF3, SERPINA1, TIMP1, FN1, and TPO as well as relatively novel or uncharacterized genes such as TGFA, QPCT, CRABP1, FCGBP, EPS8 and PROS1.
Use of logic relationships to decipher protein network organization.
Yeates et al., Los Angeles, United States. In Science, 2005
For example, protein C may be present in a genome only if proteins A and B are both present.
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