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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Proteinase 3

proteinase 3, PR3, Myeloblastin, c-ANCA
Top mentioned proteins: myeloperoxidase, HAD, CAN, elastase, AGE
Papers using proteinase 3 antibodies
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.
Supplier
Gasset Maria, In PLoS ONE, 1986
... Human neutrophil elastase (HNE) (EC 3.4.21.37), was obtained from Biocentrum (Krakow, Poland), human proteinase 3 (Pr3) (EC 3.4.21.76) was from Athens Research and Technology (Athens, USA) and cathepsin ...
Papers on proteinase 3
Homo- and Heterodinuclear Ir and Rh Imine-functionalized Protic NHC Complexes: Synthetic, Structural Studies, and Tautomerization/Metallotropism Insights.
New
Braunstein et al., Strasbourg, France. In Chemistry, Feb 2016
Addition of PR3 to complex 3 a(+) [PF6 ](-) afforded the eighteen-valence-electron complexes [Ir(cod)(PR3 ){C3 H3 N2 (DippNCMe)-κ(2) (C2,Nimine )}](+) [PF6 ](-) (7 a(+) [PF6 ](-) (R=Ph) and 7 b(+) [PF6 ](-) (R=Me)).
IgA- and SIgA anti-PR3 antibodies in serum versus organ involvement and disease activity in PR3-ANCA associated vasculitis.
New
Kastbom et al., Linköping, Sweden. In Clin Exp Immunol, Feb 2016
UNASSIGNED: Circulating IgA class anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) have been reported in ANCA-associated vasculitis (AAV) with mucosal involvement.
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines.
New
Martin et al., Dublin, Ireland. In Cell Rep, Feb 2016
Here, we show that IL-36α, IL-36β, and IL-36γ are activated differentially by the neutrophil granule-derived proteases cathepsin G, elastase, and proteinase-3, increasing their biological activity ∼500-fold.
Biocontrol potential of Trichoderma harzianum isolate T-aloe against Sclerotinia sclerotiorum in soybean.
New
Li et al., China. In Plant Physiol Biochem, Feb 2016
The defense-related genes PR1, PR2, and PR3 were expressed in the leaves of T-aloe-treated plants.
Usefulness of antineutrophil cytoplasmic autoantibodies in diagnosing and managing systemic vasculitis.
Review
New
Kallenberg, Groningen, Netherlands. In Curr Opin Rheumatol, Jan 2016
ANCA testing should be done in the right clinical context as positive results for PR3-ANCA and MPO-ANCA do occur in other conditions than vasculitis as well.
Group 11 complexes with amino acid derivatives: Synthesis and antitumoral studies.
New
Gimeno et al., Zaragoza, Spain. In J Inorg Biochem, Jan 2016
The amino acid esters have been modified by introducing an aromatic amine as pyridine that coordinates metal fragments through the nitrogen atom, giving complexes of the type [M(L)(PR3)](+) or [AuCl3(L)] (L=l-valine-N-(4-pyridylcarbonyl) methyl ester (L1), l-alanine-N-(4-pyridylcarbonyl) methyl ester (L2), l-phenylalanine-N-(4-pyridylcarbonyl) methyl-ester) (L3); M=Au(I), Ag(I), Cu(I), PR3=PPh3, PPh2py).
Nickel and iron pincer complexes as catalysts for the reduction of carbonyl compounds.
New
Impact
Guan et al., Cincinnati, United States. In Acc Chem Res, Aug 2015
Cyclometalation of bis(phosphinite)-based pincer ligands with low-valent iron species "Fe(PR3)4" results in diamagnetic Fe(II) hydride complexes, which are active catalysts for the hydrosilylation of aldehydes and ketones.
Diiron azadithiolates as models for the [FeFe]-hydrogenase active site and paradigm for the role of the second coordination sphere.
New
Impact
Rauchfuss, Urbana, United States. In Acc Chem Res, Aug 2015
Weak acids protonate Fe2(adt(R))(CO)2(PR3)4 to give terminal hydrido (term-H) complexes.
Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial.
New
Impact
Mason et al., Montréal, Canada. In J Clin Oncol, Aug 2015
PURPOSE: The NCIC CTG PR3/MRC PR07 randomized phase III trial compared androgen-deprivation therapy (ADT) alone versus ADT with radiotherapy (RT) for patients with locally advanced prostate cancer.
Pathogenesis and treatment of ANCA-associated vasculitides.
Review
New
Kallenberg, Groningen, Netherlands. In Clin Exp Rheumatol, Jul 2015
In particular, the B-cell depleting antibody rituximab has been shown non-inferior to cyclophosphamide for induction of remission, and even superior in patients with relapsing disease being positive for PR3-ANCA.
Granulomatosis with polyangiitis in pregnancy - clinical implications and treatment possibilities.
Review
New
Puszczewicz et al., Poznań, Poland. In Eur Rev Med Pharmacol Sci, Jul 2015
Autoantibody c-ANCA may be used as a marker of disease activity and individual follow-up.
Epigenetics and Vasculitis: a Comprehensive Review.
Review
New
Sawalha et al., Ann Arbor, United States. In Clin Rev Allergy Immunol, Jul 2015
Histone modifications in the PR3 and MPO gene loci might be mechanistically involved in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
Recent pathogenetic advances in ANCA-associated vasculitis.
Review
New
Nachman et al., Chapel Hill, United States. In Presse Med, Jun 2015
A European genome-wide association study (GWAS) revealed the importance of the genetic contribution of proteinase 3 (PR3) and its endogenous inhibitor, alpha (1)-antitrypsin as well as HLA risk.
Dietary modulation of the microbiome affects autoinflammatory disease.
Impact
Kanneganti et al., Memphis, United States. In Nature, 2015
We further demonstrate that combined deletion of caspases 1 and 8 was required for protection against IL-1β-dependent inflammatory bone disease, whereas the deletion of either caspase alone or of elastase or neutrophil proteinase 3 failed to prevent inflammatory disease.
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
GeneRIF
Witko-Sarsat et al., Paris, France. In J Immunol, 2012
Phagocytosis of apoptotic PR3-expressing cells potentiates proinflammatory cytokines in vivo by resident murine peritoneal macrophages.
Genetically distinct subsets within ANCA-associated vasculitis.
Impact
Smith et al., Cambridge, United Kingdom. In N Engl J Med, 2012
Anti-proteinase 3 ANCA was associated with HLA-DP and the genes encoding α(1)-antitrypsin (SERPINA1) and proteinase 3 (PRTN3) (P=6.2×10(-89),
Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity.
GeneRIF
Kim et al., Seoul, South Korea. In J Biol Chem, 2012
the dual functions (activation/termination) of PR3 in IL-33 biological activity.
Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.
GeneRIF
Newman et al., Milwaukee, United States. In J Immunol, 2012
PR3 expression and activity are significantly increased on transmigrating neutrophils; PR3 and NB1/CD177 interactions may play a role in aiding neutrophil transmigration.
KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma.
GeneRIF
Weder et al., Zürich, Switzerland. In Cancer Genomics Proteomics, 2012
the activity of myeloblastin was significantly altered in the lung adenocarcinoma biopsies harboring a KRAS gene mutation.
Early plasma exchange improves outcome in PR3-ANCA-positive renal vasculitis.
GeneRIF
Ivarsen et al., Århus, Denmark. In Clin Exp Rheumatol, 2012
Early plasma exchange in addition to cyclophosphamide/glucocorticoid treatment improves outcome in PR3-ANCA-positive renal vasculitis.
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