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Protein tyrosine phosphatase, non-receptor type 1

Protein-Tyrosine-Phosphatase, PTP1B
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, ACID, CAN, Pts, V1a
Papers using Protein-Tyrosine-Phosphatase antibodies
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study
Supplier
Beguinot Francesco et al., In Diabetes, 2007
... The PGC-1α, actin, IR, Pbx1, Syp, SHP1, PTP1B, G6Pase, and PEPCK antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Type 1 diabetes: pathogenesis and prevention
Supplier
Shivaprasad H. N. et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2005
... Human recombinant PTP1B (BIOMOL International LP (Plymouth Meeting, ...
Papers on Protein-Tyrosine-Phosphatase
Leptin signalling pathways in hypothalamic neurons.
Review
New
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
These include SOCS3, tyrosine phosphatase PTP1B, and inflammatory signaling pathways such as IKK-NFκB and JNK signaling, and ER stress-mitochondrial signaling.
Cipacinoids A-D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens.
New
Yue et al., Shanghai, China. In Org Lett, Feb 2016
Compound 1 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibition.
Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor.
New
Wozniak et al., Gdańsk, Poland. In Oncotarget, Feb 2016
Due to the fact that chicoric acid promotes phagocytic activity and was reported as an allosteric inhibitor of the PTP1B phosphatase, we examined the effect of CA on YopH phosphatase from pathogenic bacteria, which block phagocytic processes of a host cell.
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells.
New
Li et al., Hefei, China. In Toxicol Appl Pharmacol, Jan 2016
Protein tyrosine phosphatase 1B (PTP1B), a prototype of non-receptor protein tyrosine phosphatase, is proved to be a vital modulator in cardiac fibrogenesis.
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
New
Guo et al., Shanghai, China. In Bioorg Med Chem Lett, Jan 2016
Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated.
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Review
New
Li et al., Hefei, China. In Toxicology, Dec 2015
Protein tyrosine phosphatase 1B (PTP1B), a classical non-transmembrane tyrosine phosphatase, is a pivotal regulator and promising drug target in type 2 diabetes and obesity.
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Review
New
Tiganis et al., Indianapolis, United States. In Trends Pharmacol Sci, Oct 2015
In rodents, this has been attributed partly to the increased expression of the tyrosine phosphatases Protein Tyrosine Phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP), which attenuate leptin and insulin signaling.
Potential Bioactive Compounds from Seaweed for Diabetes Management.
Review
New
Phang et al., Kuala Lumpur, Malaysia. In Mar Drugs, Aug 2015
In this review, we discussed the diversity of seaweed composition and bioactive compounds which are potentially useful in preventing or managing T2DM by targeting various pharmacologically relevant routes including inhibition of enzymes such as α-glucosidase, α-amylase, lipase, aldose reductase, protein tyrosine phosphatase 1B (PTP1B) and dipeptidyl-peptidase-4 (DPP-4).
Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
Review
New
Bharti et al., Bilāspur, India. In Eur J Med Chem, Apr 2015
Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-γ, DPP-4, α-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
New
Impact
Tiganis et al., Australia. In Cell, Feb 2015
Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure.
Hypoglycemic Activity of Polysaccharide from Fruiting Bodies of the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes), on Mice Induced by Alloxan and Its Potential Mechanism.
Zhang et al., Shanghai, China. In Int J Med Mushrooms, 2014
The data on mice spleen lymphocyte proliferation and protein tyrosine phosphatase 1B (PTP1B)-inhibiting activity of fractions indicate that the hypoglycemic activity of CC60 is possibly activated through immune stimulation, not PTP1B inhibition.
PTP1B is an effector of activin signaling and regulates neural specification of embryonic stem cells.
Impact
Sun et al., Brno, Czech Republic. In Cell Stem Cell, 2014
In this study, we report a role for protein tyrosine phosphatase 1B (PTP1B) in Activin-mediated early fate decisions during ESC differentiation and show that PTP1B acts as an effector of the Activin pathway to specify mesendodermal or neural fate.
Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases.
Impact
Loria et al., New Haven, United States. In Science, 2013
The PTPs, YopH and PTP1B, have very different catalytic rates; however, we find in both that the active-site loop closes to its catalytically competent position at rates that mirror the phosphotyrosine cleavage kinetics.
The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.
GeneRIF
Hengge et al., Logan, United States. In Arch Biochem Biophys, 2012
molecular details associated with loop movement in PTPs from different organisms
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
GeneRIF
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that PTP1B is important component in regulation of energy balance by pro-opiomelanocortin-positive neurons in the hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin (or appetite depressants) to the hindbrain.
Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.
GeneRIF
Bence et al., Philadelphia, United States. In Endocrinology, 2012
Data suggest that PTP1B independent of leptin signaling may also contribute to energy balance in mice.
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Impact
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
Here, we demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex, thereby suppressing HGF-dependent MET phosphorylation and tumor cell migration.
Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.
GeneRIF
Bastiaens et al., Boston, United States. In Plos One, 2011
Studies using PTP1B mutants show that the endoplasmic reticulum anchor plays an important role in restricting its interactions with plasma membrane substrates mainly to regions of cell-cell contact.
ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface.
GeneRIF
Arregui et al., Buenos Aires, Argentina. In Plos One, 2011
ER-bound PTP1B dynamically interacts with the negative regulatory site at the C-terminus of Src at random puncta in the plasma membrane/substrate interface, likely leading to Src activation and recruitment to adhesion complexes.
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Impact
Tiganis et al., Australia. In Cell Metab, 2011
Increased expression of protein tyrosine phosphatase 1B (PTP1B) has been associated with the attenuation of leptin signaling and development of cellular leptin resistance.
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