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Serpin peptidase inhibitor, clade A

protein Z-dependent protease inhibitor, PZI, PZ-dependent protease inhibitor, rasp-1
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010] (from NCBI)
Papers on protein Z-dependent protease inhibitor
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Olson et al., Chicago, United States. In Blood, 2012
The study shows by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are crucial hot spots for PZ binding.
Characterization of the heparin-binding site of the protein z-dependent protease inhibitor.
Rezaie et al., Saint Louis, United States. In Biochemistry, 2012
heparin-binding site of ZPI was mapped: basic residues of both helices C and D of ZPI interact with heparin to modulate the inhibitory function of the serpin.
Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor.
Harper et al., Auckland, New Zealand. In Thromb Haemost, 2012
Report two missense mutations identified in venous thrombosis patients impair the inhibitory function of the ZPI were not convincingly associted with thrombosis risk.
Co-localization of Protein Z, Protein Z-Dependent protease inhibitor and coagulation factor X in human colon cancer tissue: implications for coagulation regulation on tumor cells.
Kisiel et al., BiaƂystok, Poland. In Thromb Res, 2012
localization of PZ/ZPI and FX in colon cancer cells indicates that PZ/ZPI may contribute to anticoagulant events at the tumor site.
Increase in the plasma levels of protein Z-dependent protease inhibitor in normal pregnancies but not in non-pregnant patients with unexplained recurrent miscarriage.
Ichinose et al., Yamagata, Japan. In Thromb Haemost, 2012
Plasma ZPI levels were unchanged in non-pregnant recurrent miscarriage women, while the plasma PZ level was slightly reduced, a finding consistent with existing reports.
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