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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Serpin peptidase inhibitor, clade A

protein Z-dependent protease inhibitor, PZI, PZ-dependent protease inhibitor, rasp-1
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: PZ, ACID, CAN, AGE, Insulin
Papers on protein Z-dependent protease inhibitor
The plasma levels of protein Z-dependent protease inhibitor increase after gynecological surgery independently of estrogen.
Ichinose et al., Yamagata, Japan. In Thromb Res, Nov 2015
INTRODUCTION: Protein Z (PZ)-dependent protease inhibitor (ZPI) is a serine protease inhibitor that efficiently inhibits activated factor X when ZPI is in complex with PZ.
Protein Z G79A polymorphism and puerperal cerebral venous thrombosis.
Christopher et al., Bengaluru, India. In Clin Appl Thromb Hemost, Nov 2015
Protein Z (PZ), a cofactor for PZ-dependent protease inhibitor, is known to play an important role in inhibiting the coagulation cascade.
Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.
Olson et al., Shanghai, China. In J Biol Chem, May 2015
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), circulates in blood as a tight complex with its cofactor, protein Z (PZ), enabling it to function as a rapid inhibitor of membrane-associated factor Xa. Here, we show that N,N'-dimethyl-N-(acetyl)-N'-(7-nitrobenz-3-oxa-1,3-diazol-4-yl)ethylenediamine (NBD)-fluorophore-labeled K239C ZPI is a sensitive, moderately perturbing reporter of the ZPI-PZ interaction and utilize the labeled ZPI to characterize in-depth the thermodynamics and kinetics of wild-type and variant ZPI-PZ interactions.
Prominent protein Z-induced thrombin inhibition in cirrhosis: a new functional assay for hypercoagulability assessment.
Kim et al., Seoul, South Korea. In J Gastroenterol Hepatol, Apr 2015
BACKGROUND AND AIMS: Protein Z (PZ) is an anticoagulant that accelerates the inhibitory effect of PZ-dependent protease inhibitor (ZPI) on coagulation factor Xa. We assessed functional status of PZ system in 158 patients with liver cirrhosis and 59 healthy controls.
Identification of vinculin as a potential plasma marker for age-related macular degeneration.
Lee et al., Seoul, South Korea. In Invest Ophthalmol Vis Sci, 2014
RESULTS: Out of 320 proteins identified, vinculin, protein S100A9, triosephosphate isomerase, protein S100A8, protein Z-dependent protease inhibitor, C-X-C motif chemokine 7, and tenascin X showed significantly differential expression in AMD patient plasma compared to control plasma.
Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z.
Rezaie et al., Saint Louis, United States. In Biochim Biophys Acta, 2014
BACKGROUND: Protein Z (PZ) has been reported to promote the inactivation of factor Xa (FXa) by PZ-dependent protease inhibitor (ZPI) by about three orders of magnitude.
Protein Z/protein Z-dependent protease inhibitor system in loco in human gastric cancer.
Kisiel et al., Białystok, Poland. In Ann Hematol, 2014
The protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) complex inhibits factor Xa proteolytic activity.
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction.
Vollmar et al., Rostock, Germany. In Crit Care Med, 2013
SUBJECTS, INTERVENTIONS, AND MEASUREMENTS: Using intravital fluorescence microscopy in protein Z-dependent protease inhibitor deficient (ZPI) and protein Z deficient (PZ) mice, as well as their wild-type littermates (ZPI, PZ), kinetics of light/dye-induced thrombus formation and microhemodynamics were assessed in randomly chosen venules.
Structural analysis of protein Z gene variants in patients with foetal losses.
Grandone et al., San Giovanni Rotondo, Italy. In Thromb Haemost, 2013
Crystal structures of PZ in complex with the PZ-dependent inhibitor (PZI) have been recently obtained.
Protein Z, an anticoagulant protein with expanding role in reproductive biology.
Almawi et al., Manama, Bahrain. In Reproduction, 2013
Instead, PZ acts as a cofactor for the inhibition of factor Xa through the serpin PZ-dependent protease inhibitor (ZPI).
Residues of the 39-loop restrict the plasma inhibitor specificity of factor IXa.
Rezaie et al., Saint Louis, United States. In J Biol Chem, 2013
The two plasma inhibitors, protein Z-dependent protease inhibitor (ZPI) and tissue factor pathway inhibitor (TFPI), effectively inhibit the activity of activated factor X (FXa); however, neither inhibitor exhibits any reactivity with the homologous protease activated factor IX (FIXa).
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Olson et al., Chicago, United States. In Blood, 2012
The study shows by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are crucial hot spots for PZ binding.
Characterization of the heparin-binding site of the protein z-dependent protease inhibitor.
Rezaie et al., Saint Louis, United States. In Biochemistry, 2012
heparin-binding site of ZPI was mapped: basic residues of both helices C and D of ZPI interact with heparin to modulate the inhibitory function of the serpin.
Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor.
Harper et al., Auckland, New Zealand. In Thromb Haemost, 2012
Report two missense mutations identified in venous thrombosis patients impair the inhibitory function of the ZPI were not convincingly associted with thrombosis risk.
Co-localization of Protein Z, Protein Z-Dependent protease inhibitor and coagulation factor X in human colon cancer tissue: implications for coagulation regulation on tumor cells.
Kisiel et al., Białystok, Poland. In Thromb Res, 2012
localization of PZ/ZPI and FX in colon cancer cells indicates that PZ/ZPI may contribute to anticoagulant events at the tumor site.
Increase in the plasma levels of protein Z-dependent protease inhibitor in normal pregnancies but not in non-pregnant patients with unexplained recurrent miscarriage.
Ichinose et al., Yamagata, Japan. In Thromb Haemost, 2012
Plasma ZPI levels were unchanged in non-pregnant recurrent miscarriage women, while the plasma PZ level was slightly reduced, a finding consistent with existing reports.
The protein Z/protein Z-dependent protease inhibitor complex. Systemic or local control of coagulation?
Vasse, Rouen, France. In Hamostaseologie, 2011
It is a cofactor of a serpin, the protein Z-dependent protease inhibitor (ZPI), and the complex PZ/ZPI inhibits activated factor X on phospholipid surfaces.
Protein Z, a protein seeking a pathology.
Vasse, Rouen, France. In Thromb Haemost, 2008
In contrast to these factors, PZ does not possess any enzymatic activity but is involved as a cofactor in the down-regulation of coagulation by forming a complex with the protein Z-dependent protease inhibitor (ZPI).
Serpins in thrombosis, hemostasis and fibrinolysis.
Church et al., Chapel Hill, United States. In J Thromb Haemost, 2007
This review describes key serpins important in the regulation of these pathways: antithrombin, heparin cofactor II, protein Z-dependent protease inhibitor, alpha(1)-protease inhibitor, protein C inhibitor, alpha(2)-antiplasmin and plasminogen activator inhibitor-1.
Determinants of specificity of factor xa interaction with its physiological inhibitors.
Rezaie, Saint Louis, United States. In Mini Rev Med Chem, 2006
The proteolytic activity of fXa in plasma is primarily regulated by three physiological inhibitors, antithrombin (AT), protein Z-dependent protease inhibitor (ZPI) and tissue factor pathway inhibitor (TFPI).
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