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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Acid phosphatase 1, soluble

Protein Tyrosine Phosphatase, ACP1, red cell acid phosphatase, LMW-PTP
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, Phosphoglucomutase, ESD, Lactoylglutathione Lyase, CAN
Papers using Protein Tyrosine Phosphatase antibodies
The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors
Supplier
Linden Rafael, In PLoS ONE, 2005
... LMW-PTP (ACP1) antibody was obtained from Abcam.
Papers on Protein Tyrosine Phosphatase
Acute Morphine, Chronic Morphine, and Morphine Withdrawal Differently Affect Pleiotrophin, Midkine, and Receptor Protein Tyrosine Phosphatase β/ζ Regulation in the Ventral Tegmental Area.
New
Milanés et al., Murcia, Spain. In Mol Neurobiol, Feb 2016
PTN or MK, signaling through receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ), lead to the activation of extracellular signal-regulated kinases (ERKs) and thymoma viral proto-oncogene (Akt), which induce morphological changes and modulate addictive behaviors.
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
New
Li et al., Vienna, Austria. In Behav Brain Res, Jan 2016
In addition, our analysis showed protein kinases WNK1, LYN, VRK1, ABL1, CDK4, CDKL3, SgK223 and ADCK1, and protein phosphatases PTPRF, ACP1, DNAJC6, SSH2 and UBASH3B that have not been directly linked to fear memory processes so far.
Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma.
New
Liu et al., China. In Pathol Oncol Res, Jan 2016
UNASSIGNED: Protein Tyrosine Phosphatase Receptor J (PTPRJ) has been reported to be a tumor suppressor in various human cancers.
Reactions of 1,3-Diketones with a Dipeptide Isothiazolidin-3-one: Toward Agents That Covalently Capture Oxidized Protein Tyrosine Phosphatase 1B.
New
Gates et al., Columbia, United States. In J Org Chem, Jan 2016
Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for the treatment of type 2 diabetes; however, the enzyme has been classified by some as an "undruggable target".
Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina.
New
Valverde et al., Madrid, Spain. In Invest Ophthalmol Vis Sci, Jan 2016
Protein tyrosine phosphatase 1B (PTP1B) negatively modulates IGF-IR signaling, but its involvement in inflammation during DR remains unknown.
The extended human PTPome: A growing tyrosine phosphatase family.
Review
New
Pulido et al., Valladolid, Spain. In Febs J, Dec 2015
This activity is found in several structurally diverse protein families, including Protein Tyrosine Phosphatase (PTP), Arsenate Reductase, Rhodanese, Haloacid Dehalogenase (HAD), and Histidine Phosphatase (HP) families.
Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
New
Johnson et al., Logan, United States. In Biochemistry, Nov 2015
Catalysis in protein tyrosine phosphatases (PTPs) involves movement of a protein loop called the WPD loop that brings a conserved aspartic acid into the active site to function as a general acid.
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Review
New
Tiganis et al., Indianapolis, United States. In Trends Pharmacol Sci, Oct 2015
In rodents, this has been attributed partly to the increased expression of the tyrosine phosphatases Protein Tyrosine Phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP), which attenuate leptin and insulin signaling.
Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.
New
Impact
Reizis et al., New York City, United States. In Immunity, Sep 2015
We report that within the human immune system, receptor protein tyrosine phosphatase sigma (PTPRS) is expressed specifically on pDCs.
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Review
Wang et al., China. In Asian Pac J Cancer Prev, 2014
Receptor-type protein tyrosine phosphatase O (PTPRO) as one member of the PTPs family has also been identified to have some roles in tumor development.
Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.
Luo et al., Baoding, China. In Sci Rep, 2014
Shp2 is a ubiquitously expressed protein tyrosine phosphatase (PTP) related to adult acute myelogenous leukemia and human solid tumors.
Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism.
Review
Chiariello et al., Roma, Italy. In World J Cardiol, 2014
In the present note we have studied the effect of p53 codon 72, acid phosphatse locus 1 (ACP1) and adenosine deaminase (ADA) genetic polymorphism on the strength of association between PTPN22 and CAD.
Allosteric Small Molecule Inhibitors of LMPTP
Review
Bottini et al., Bethesda, United States. In Unknown Journal, 2014
The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, represents an attractive target in this family.
Lack of association of ACP1 gene with inflammatory bowel disease: a case-control study.
GeneRIF
Martin et al., Granada, Spain. In Tissue Antigens, 2012
lack of association with inflammatory bowel disease in Spanish patients
Acid phosphatase locus 1 genetic polymorphism and cancer grading.
GeneRIF
Bottini et al., Roma, Italy. In Am J Med Sci, 2012
There is a significant association between acid phosphatase locus 1 (ACP(1) and cancer grade, mainly due to ACP(1) genotypes carrying the *C allele that are much less represented in patients with low grade when compared with those with high grade.
Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus.
GeneRIF
Martin et al., Granada, Spain. In Hum Immunol, 2012
Data indicate that ACP1 rs11553742*T with increased susceptibility in systemic lupus erythematosus (SLE) patients.
Array comparative genomic hybridization analysis identifies recurrent gain of chromosome 2p25.3 involving the ACP1 and MYCN genes in chronic lymphocytic leukemia.
GeneRIF
Luthra et al., Houston, United States. In Clin Lymphoma Myeloma Leuk, 2011
Gain of the telomeric region 2p25.3 harboring the ACP1 gene is common in CLL (25%, 44 of 178 cases).
Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients.
GeneRIF
Martin et al., Granada, Spain. In Arthritis Res Ther, 2010
the ACP1*C allele influences the risk of cardiovascular disease events in patients with rheumatoid arthritis.
Redox-dependent downregulation of Rho by Rac.
Impact
Bar-Sagi et al., Stony Brook, United States. In Nat Cell Biol, 2003
The pathway linking generation of ROS to downregulation of Rho involves inhibition of the low-molecular-weight protein tyrosine phosphatase (LMW-PTP) and then an increase in the tyrosine phosphorylation and activation of its target, p190Rho-GAP.
ACID PHOSPHATASES OF HUMAN RED CELLS: PREDICTED PHENOTYPE CONFORMS TO A GENETIC HYPOTHESIS.
Impact
STEINBERG et al., In Science, 1964
Analysis of data from 80 families and 369 unrelated individuals confirms the hypothesis that human red cell acid phosphatase phenotypes are determined by three codominant alleles at a single autosomal locus.
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