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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein phosphatase 2, catalytic subunit, beta isozyme

protein phosphatase 2A catalytic subunit, PPP2CB, PP2A beta, PP2A2
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: PP2A, Replication Protein C, ACID, CAN, V1a
Papers on protein phosphatase 2A catalytic subunit
The Association Between p38 MAPK-Mediated TNF-α/TNFR2 up-Regulation and 2-(4-Aminophenyl)-7-Methoxybenzothiazole-Induced Apoptosis in Human Leukemia U937 Cells.
New
Chang et al., Kao-hsiung, Taiwan. In J Cell Physiol, Jan 2016
Treatment with 7-OMe-APBT up-regulated protein phosphatase 2A catalytic subunit α (PP2Acα) expression via the p38 MAPK/c-Jun/ATF-2 pathway, which, in turn, promoted tristetraprolin (TTP) degradation.
Ppp2ca knockout in mice spermatogenesis.
New
Li et al., Nanjing, China. In Reproduction, Apr 2015
The homolog PPP2CA and PPP2CB can each function as the phosphatase catalytic subunit generally referred to as PP2AC.
A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.
Torres et al., Los Angeles, United States. In Cell Cycle, 2014
Leucine carboxyl methyltransferase-1 (LCMT1) and protein phosphatase methylesterase-1 (PME-1) are essential enzymes that regulate the methylation of the protein phosphatase 2A catalytic subunit (PP2AC).
Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells.
Chang et al., Kao-hsiung, Taiwan. In J Cell Physiol, 2014
p38 MAPK/JNK activation led to up-regulation of protein phosphatase 2A catalytic subunit α (PP2Acα) in amsacrine-treated U937 cells.
Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.
Too et al., Halifax, Canada. In Mol Cell Endocrinol, 2014
Mammalian α4 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PP2Ac) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible EDD E3 ubiquitin ligase.
[Down-regulated expression of PP2A catalytic subunit in pancreatic cancer cells promotes cell growth].
Xu et al., Suzhou, China. In Zhonghua Yi Xue Za Zhi, 2014
OBJECTIVE: To investigate the expression of protein phosphatase 2A catalytic subunit (PP2Ac) in pancreatic cancer and the regulation of this gene on JNK/c-Jun/AP-1 pathway and cell growth.
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.
Heim et al., In Carcinogenesis, 2014
Transgenic expression of HCV proteins in the mouse liver induces an overexpression of the protein phosphatase 2A catalytic subunit (PP2Ac).
Resolving tumor heterogeneity: genes involved in chordoma cell development identified by low-template analysis of morphologically distinct cells.
Rinner et al., Graz, Austria. In Plos One, 2013
The mannosyltransferase ALG11 (695-fold) and the phosphatase subunit PPP2CB (18.6-fold) were found to be up-regulated in large physaliferous MUG-Chor1 cells showing a similar trend in U-CH1 cells.
Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells.
Chang et al., Kao-hsiung, Taiwan. In Cell Signal, 2013
This study explores the signaling transduction cascade of ERK and p38 MAPK on regulating MAPK phosphatase-1 (MKP-1) and protein phosphatase 2A catalytic subunit α (PP2Acα) expression in caffeine-treated human leukemia U937 cells.
[Gene therapy using a dominant negative form of the protein phosphatase 2A catalytic subunit a driven by a hepatoma tissue-specific promoter achieves effective growth inhibition of hepatoma cells].
Chen et al., Suzhou, China. In Zhonghua Gan Zang Bing Za Zhi, 2013
OBJECTIVE: To generate a gene delivery plasmid carrying the dominant negative form of the protein phosphatase 2A catalytic subunit a (DN-PP2Aca) driven by a hepatocellular carcinoma (HCC) tissue-specific promoter and investigate its ability to inhibit growth of cultured hepatoma cells.
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
Le Marchand et al., Honolulu, United States. In Genes Chromosomes Cancer, 2013
Copy number loss at 8p, a CNA associated with adenocarcinoma and poor prognosis, was observed in >50% of the tumor samples and demonstrated a significant linear correlation for gene dosage and gene expression for two potential tumor suppressor genes, MTUS1 (8p22) and PPP2CB (8p12).
Protein phosphatase 2A catalytic subunit α plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance.
Chen et al., Chapel Hill, United States. In Cell Rep, 2013
Using quantitative proteomics to enumerate the inflammation-phenotypic constituents of the MyD88 interactome, we found that in endotoxin-tolerant macrophages, protein phosphatase 2A catalytic subunit α (PP2Ac) enhances its association with MyD88 and is constitutively activated.
Comparative proteomic analysis of the nucleus accumbens during extinction and reinstatement of morphine dependence.
Luo et al., Chongqing, China. In West Indian Med J, 2013
RESULTS: The proteins were classified as fatty acid-binding protein, serine/threonine protein phosphatase 2A catalytic subunit beta isoform, serine/threonine protein phosphatase 2A catalytic subunit alpha isoform, serine/threonine protein phosphatase 2A regulatory subunit B2 subunit gamma or heat shock protein 90 co-chaperone CDC37.
Whole genome sequencing identifies a deletion in protein phosphatase 2A that affects its stability and localization in Chlamydomonas reinhardtii.
Dutcher et al., Saint Louis, United States. In Plos Genet, 2012
A comparison of polymorphisms in the imp3 strain and the other 15 strains allowed us to identify a deletion of the last three amino acids, Y313F314L315, in a protein phosphatase 2A catalytic subunit (PP2A3) in the imp3 strain.
MARF1 regulates essential oogenic processes in mice.
Impact
Eppig et al., Bar Harbor, United States. In Science, 2012
Up-regulation of protein phosphatase 2 catalytic subunit (PPP2CB) is key to the meiotic arrest phenotype.
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
GeneRIF
Roeder et al., Palmerston North, New Zealand. In J Biol Chem, 2011
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
GeneRIF
Zhou et al., Xiamen, China. In Genes Dev, 2008
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.
GeneRIF
Iqbal et al., New York City, United States. In J Biol Chem, 2008
I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A
Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.
GeneRIF
Schulz et al., Düsseldorf, Germany. In Cancer Genomics Proteomics, 2008
These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors.
Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells.
GeneRIF
Kowluru et al., Detroit, United States. In Endocrine, 2007
a positive modulatory role for PP2Ac in signaling steps leading to glucose-stimulated insulin secretion
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