protein phosphatase 1
Genome-wide association study reveals sex-specific selection signals against autosomal nucleotide variants.
Seoul, South Korea. In J Hum Genet, Feb 2016
Further analysis with an independent data set confirmed two intragenic association signals in the genes encoding protein phosphatase 1, regulatory subunit 12B (PPP1R12B, intron 12, rs1819043) and dynein, axonemal, heavy chain 11 (DNAH11, intron 61, rs10255013), which are directly involved in the reproductive system.
Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.
Heidelberg, Germany. In Cell, Dec 2015
Post-transcriptional Wnt signaling impacts spermatozoa through GSK3 by (1) reducing global protein poly-ubiquitination to maintain protein homeostasis; (2) inhibiting septin 4 phosphorylation to establish a membrane diffusion barrier in the sperm tail; and (3) inhibiting protein phosphatase 1 to initiate sperm motility.
Kinetochore components are required for central spindle assembly.
Paris, France. In Nat Cell Biol, May 2015
Specifically, central spindle microtubule assembly is dependent on kinetochore recruitment of the scaffold protein KNL-1, as well as downstream partners BUB-1, HCP-1/2(CENP-F) and CLS-2(CLASP); and is negatively regulated by kinetochore-associated protein phosphatase 1 activity.
Myocardial glycogen dynamics: new perspectives on disease mechanisms.
Melbourne, Australia. In Clin Exp Pharmacol Physiol, Apr 2015
Signalling pathways appear to converge on glycogen regulatory enzymes via insulin (glycogen synthase kinase 3β, protein phosphatase 1, allosteric action of glucose-6-phosphate), β-adrenergic (phosphorylase kinase protein phosphatase 1 inhibitor), and 5' adenosine monophosphate-activated protein kinase (allosteric action of glucose-6-phosphate, direct glycogen binding, insulin receptor).
A PP1-PP2A phosphatase relay controls mitotic progression.
Manchester, United Kingdom. In Nature, 2015
Although Cdc14 phosphatase drives this reversal in budding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) activities have each been independently linked to mitotic exit control in other eukaryotes.