Metabolism of activated T lymphocytes.
Saskatoon, Canada. In Curr Opin Immunol, 17 Mar 2014
In contrast, T regulatory (Treg) cells are generated when AMP-Activating Protein Kinase signaling is activated and mTOR activation is suppressed.
Systemic medical management of diabetic retinopathy.
Singapore, Singapore. In Middle East Afr J Ophthalmol, Oct 2013
Other drugs being tried are the Protein Kinase C (PKC) inhibitors, other peroxisome proliferator-activated receptors (PPAR) agonists, Forsoklin (which binds GLUT 1 receptor), minocycline (for its anti inflammatory effect), and Celecoxib (Cox-2 inhibitor).
Regulation of miRNA biogenesis as an integrated component of growth factor signaling.
San Francisco, United States. In Curr Opin Cell Biol, Apr 2013
In this article we use well-characterized growth-factor signaling pathways such as transforming growth factor-β (TGF-β), Protein Kinase B (PKB, also known as Akt) and extracellular-signal-regulated kinase (ERK) to illustrate how basic cell signaling pathways modulate the activities of these components of the miRNA biogenesis pathway to achieve optimal miRNA expression patterns.