Application of RNAi to Genomic Drug Target Validation in Schistosomes.
London, United Kingdom. In Plos Negl Trop Dis, 31 May 2015
Knockdown of the atypical Protein Kinase C (Smp_096310) (Sm-aPKC) resulted in loss of viability in both schistosomula and adults and led us to focus our attention on other kinase genes that were identified in the above list and through whole organism screening of known kinase inhibitor sets followed by chemogenomic evaluation.
Regulation of the cardiac Na(+) channel NaV1.5 by post-translational modifications.
Nantes, France. In J Mol Cell Cardiol, 04 Apr 2015
In this review, we examine the recent literature demonstrating glycosylation, phosphorylation by Protein Kinases A and C, Ca(2+)/Calmodulin-dependent protein Kinase II, Phosphatidylinositol 3-Kinase, Serum- and Glucocorticoid-inducible Kinases, Fyn and Adenosine Monophosphate-activated Protein Kinase, methylation, acetylation, redox modifications, and ubiquitylation of NaV1.5.
Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer.
Maywood, United States. In Front Oncol, 2013
The compensatory Notch pathway maintains HER-induced downstream signals transmitted to pathways such as Mitogen Activated Protein Kinase and Phosphatidylinositol 3-Kinase (PI3K), thereby allowing cancer cells to survive molecular targeted therapies, undergo epithelial to mesenchymal transitioning, and increase cellular invasion.