CYLD-Mediated Signaling and Diseases.
Columbia, United States. In Curr Drug Targets, 24 Nov 2014
It directly regulates multiple key signaling cascades, such as the Nuclear Factor kappa B [NF-kB] and the Mitogen-Activated Protein Kinase (MAPK) pathways, by its catalytic activity on polyubiquitinated key intermediates.
Necroptosis, in vivo detection in experimental disease models.
Gent, Belgium. In Semin Cell Dev Biol, 23 Sep 2014
Initially, Receptor-Interacting Protein Kinase 1 (RIPK1) and RIPK3 kinase activity were uniquely associated with induction of necroptosis, however recent evidence suggests pleiotropic functions in cell death, inflammation and survival, obscuring a clear picture.
Metabolism of activated T lymphocytes.
Saskatoon, Canada. In Curr Opin Immunol, Apr 2014
In contrast, T regulatory (Treg) cells are generated when AMP-Activating Protein Kinase signaling is activated and mTOR activation is suppressed.
Systemic medical management of diabetic retinopathy.
Singapore, Singapore. In Middle East Afr J Ophthalmol, Oct 2013
Other drugs being tried are the Protein Kinase C (PKC) inhibitors, other peroxisome proliferator-activated receptors (PPAR) agonists, Forsoklin (which binds GLUT 1 receptor), minocycline (for its anti inflammatory effect), and Celecoxib (Cox-2 inhibitor).