Regulation of miRNA biogenesis as an integrated component of growth factor signaling.
San Francisco, United States. In Curr Opin Cell Biol, Apr 2013
In this article we use well-characterized growth-factor signaling pathways such as transforming growth factor-β (TGF-β), Protein Kinase B (PKB, also known as Akt) and extracellular-signal-regulated kinase (ERK) to illustrate how basic cell signaling pathways modulate the activities of these components of the miRNA biogenesis pathway to achieve optimal miRNA expression patterns.
Protein kinase C-theta inhibitors: a novel therapy for inflammatory disorders.
Patiāla, India. In Curr Pharm Des, 2011
PKC-θ is a serine/threonine specific protein kinase and its activation depends upon the concentration of diacylglycerol (DAG) and phospholipids (phosphatidylserine). PKC-θ phosphorylates a variety of proteins that are known to be involved in the diverse cellular signaling pathways.