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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 May 2015.

Casein kinase 1, delta

Protein Kinase
Top mentioned proteins: CAN, MAPK, V1a, Akt, ACID
Papers on Protein Kinase
The Potential of Enzastaurin to Enhance Platelet Aggregation and Growth Factor Secretion: Implications for Cancer Cell Survival.
New
Jurasz et al., Edmonton, Canada. In J Thromb Haemost, 20 Jun 2015
BACKGROUND: Enzastaurin is a Protein Kinase-Cβ (PKCβ) inhibitor with anti-proliferative and pro-apoptotic effects that was in clinical development for the treatment of a variety of cancers.
Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.
New
Hagiwara et al., Kyoto, Japan. In Mol Pharmacol, 20 Jun 2015
Our previous studies using SRPIN340, a small molecule inhibitor of SRPK1 (Serine-Arginine Protein Kinase 1), demonstrated that SRPK1 is a potential target for development of anti-angiogenic drug.
Nesfatin-1 Suppresses Cardiac L-type Ca Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway.
New
Zhang et al., Beijing, China. In Cell Physiol Biochem, 18 Jun 2015
METHODS: Using patch clamp, protein kinase assays, and western blot analysis, we studied the effect of NF-1 on L-type Ca(2+) currents (ICa,L) and to explore the regulatory mechanisms of this effect in adult ventricular myocytes.
Application of RNAi to Genomic Drug Target Validation in Schistosomes.
New
Bickle et al., London, United Kingdom. In Plos Negl Trop Dis, 31 May 2015
Knockdown of the atypical Protein Kinase C (Smp_096310) (Sm-aPKC) resulted in loss of viability in both schistosomula and adults and led us to focus our attention on other kinase genes that were identified in the above list and through whole organism screening of known kinase inhibitor sets followed by chemogenomic evaluation.
Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3.
New
Ding et al., Beijing, China. In Structure, 29 May 2015
By interacting with the mitogen-activated protein kinase MEKK3, CCM2 either mediates the activation of MEKK3 signaling in response to osmotic stress or negatively regulates MEKK3 signaling, which is important for normal cardiovascular development.
Pin1: Intimate Involvement with the Regulatory Protein Kinase Networks in the Global Phosphorylation Landscape.
Review
New
Gyenis et al., London, Canada. In Biochim Biophys Acta, 09 Apr 2015
MAJOR CONCLUSIONS: The relationship between Pin1 and the regulatory protein kinase networks is not restricted simply to the recognition of proteins that are substrates for proline-directed kinases.
Regulation of the cardiac Na(+) channel NaV1.5 by post-translational modifications.
Review
New
Abriel et al., Nantes, France. In J Mol Cell Cardiol, 04 Apr 2015
In this review, we examine the recent literature demonstrating glycosylation, phosphorylation by Protein Kinases A and C, Ca(2+)/Calmodulin-dependent protein Kinase II, Phosphatidylinositol 3-Kinase, Serum- and Glucocorticoid-inducible Kinases, Fyn and Adenosine Monophosphate-activated Protein Kinase, methylation, acetylation, redox modifications, and ubiquitylation of NaV1.5.
Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells.
Review
New
Isales et al., Athens, United States. In Mol Cell Endocrinol, Feb 2015
Using mouse BMMSCs, we examined the effects of the oxidized amino acids di-tyrosine and kynurenine on proliferation, differentiation and Mitogen-Activated Protein Kinase (MAPK) pathway.
TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation.
Review
New
Chang et al., Taipei, Taiwan. In Biomed Res Int, Dec 2014
UNASSIGNED: Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin.
Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer.
Review
Osipo et al., Maywood, United States. In Front Oncol, 2013
The compensatory Notch pathway maintains HER-induced downstream signals transmitted to pathways such as Mitogen Activated Protein Kinase and Phosphatidylinositol 3-Kinase (PI3K), thereby allowing cancer cells to survive molecular targeted therapies, undergo epithelial to mesenchymal transitioning, and increase cellular invasion.
3D-QSAR Analysis on ATR Protein Kinase Inhibitors Using CoMFA and CoMSIA.
Lin et al., Chongqing, China. In Curr Comput Aided Drug Des, 2013
Ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase is an attractive anticancer target.
Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.
GeneRIF
Price et al., Kansas City, United States. In Genetics, 2009
The results demonstrate a high degree of evolutionary conservation of fly and vertebrate CKIdelta and of the functions affected by their period-shortening mutations.
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction.
Impact
Tomlinson et al., New York City, United States. In Nat Cell Biol, 2005
Together, Protein Kinase A, Casein Kinase 1 and Glycogen Synthase Kinase 3 silence the pathway in the absence of ligand by phosphorylating Ci at a defined cluster of sites, thereby promoting its proteolytic conversion to a transcriptional repressor (Ci-75).
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.
Impact
Kalderon et al., New York City, United States. In Cell, 2002
Ci-155 proteolysis depends on phosphorylation at three sites by Protein Kinase A (PKA).
Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network.
Impact
Malhotra et al., San Diego, United States. In Cell, 2001
When a kinase inactive form of Protein Kinase D (PKD-K618N) was expressed in HeLa cells, it localized to the trans-Golgi network (TGN) and caused extensive tubulation.
Analogs of cyclic adenosine monophosphate: correlation of inhibition of Purkinje Neurons with Protein Kinase Activation.
Impact
Henriksen et al., In Science, 1975
with their reported potency in activating cyclic AMP-dependent protein kinase.
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