Lack of Evidence for PKM2 Protein Kinase Activity.
Cambridge, United States. In Mol Cell, 19 Sep 2015
A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a detailed biochemical characterization of this activity is lacking.
Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
Nantes, France. In J Mol Cell Cardiol, May 2015
In this review, we examine the recent literature demonstrating glycosylation, phosphorylation by Protein Kinases A and C, Ca(2+)/Calmodulin-dependent protein Kinase II, Phosphatidylinositol 3-Kinase, Serum- and Glucocorticoid-inducible Kinases, Fyn and Adenosine Monophosphate-activated Protein Kinase, methylation, acetylation, redox modifications, and ubiquitylation of Na(V)1.5.