Regulation of the cardiac Na(+) channel NaV1.5 by post-translational modifications.
Nantes, France. In J Mol Cell Cardiol, 04 Apr 2015
In this review, we examine the recent literature demonstrating glycosylation, phosphorylation by Protein Kinases A and C, Ca(2+)/Calmodulin-dependent protein Kinase II, Phosphatidylinositol 3-Kinase, Serum- and Glucocorticoid-inducible Kinases, Fyn and Adenosine Monophosphate-activated Protein Kinase, methylation, acetylation, redox modifications, and ubiquitylation of NaV1.5.
The two faces of receptor interacting protein kinase-1.
Memphis, United States. In Mol Cell, Dec 2014
Receptor Interacting Protein Kinase-1 (RIPK1), a key player in inflammation and cell death, assumes opposite functions depending on the cellular context and its posttranslational modifications.
Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer.
Maywood, United States. In Front Oncol, 2013
The compensatory Notch pathway maintains HER-induced downstream signals transmitted to pathways such as Mitogen Activated Protein Kinase and Phosphatidylinositol 3-Kinase (PI3K), thereby allowing cancer cells to survive molecular targeted therapies, undergo epithelial to mesenchymal transitioning, and increase cellular invasion.