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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inactivation no afterpotential C

Protein Kinase C, inaC
may play a critical role in fluid and electrolyte homeostasis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, CAN, ACID, HAD, Akt
Papers using Protein Kinase C antibodies
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
Supplier
Nurminsky Dmitry I., In PLoS ONE, 2002
... (Abcam, ab15309), IGFR (Cell Signaling, 111A9), EGFR, (Santacruz, sc 03, 1005), Glucose-6-P dehydrogenase (Abcam, ab34436), Protein Kinase C-zeta (Cell signaling, ab51157), P-PKC-zeta (Abcam, ab76129), ...
IgG antibodies do not bind to band 3 in intact erythrocytes; enzymatic treatment of cells is required for IgG binding
Supplier
Zingde Surekha et al., In Anemia, 1983
... Antibodies to cathepsin G; band 3 (polyclonal); protein kinase C (PKC) βII were from Abcam plc, UK (ab50845); Abnova, ...
Papers on Protein Kinase C
cPKCβ-mediated phosphorylation inhibits CRMP2 proteolysis and alleviates ischemic injury in cultured cortical neurons and ischemic stroke-induced mice.
New
Li et al., Beijing, China. In J Neurochem, Feb 2016
UNASSIGNED: We previously reported that conventional protein kinase C (cPKC)β participated in hypoxic preconditioning (HPC)-induced neuroprotection against cerebral ischemic injury, and collapsin response-mediated protein 2 (CRMP2) was identified as a cPKCβ-interacting protein.
Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-κB.
New
Gong et al., Wenzhou, China. In High Alt Med Biol, Feb 2016
Hypoxia exposure increased protein kinase C activity and promoted pulmonary artery smooth muscle cell proliferation in vitro.
Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95).
New
Wu et al., Taipei, Taiwan. In Mol Neurobiol, Feb 2016
We further demonstrated that protein kinase A (PKA) and protein kinase C isoform ε were the protein kinases responsible for phosphorylation and regulation of GAD67 and GAD65, respectively.
The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice.
New
Ryu et al., Seoul, South Korea. In Pharmacol Biochem Behav, Feb 2016
The administration of erucic acid increased the phosphorylation levels of phosphatidylinositide 3-kinase (PI3K), protein kinase C zeta (PKCζ), extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and additional protein kinase B (Akt) in the hippocampus.
Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota.
Review
New
Ghosh et al., Vellore, India. In Metabolism, Jan 2016
However, there is one common mechanism i.e. formation of esterified lipids (long chain fatty acyl CoAs) and the activation of protein kinase C δ (PKC δ) involved in all these organs.
A perspective on NETosis in diabetes and cardiometabolic disorders.
Review
New
Avogaro et al., Padova, Italy. In Nutr Metab Cardiovasc Dis, Jan 2016
Protein kinase C (PKC) and NADPH oxidase (NOX) are two important targets to counter NETosis in the setting of diabetes.
Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes.
New
Impact
Samakovlis et al., Stockholm, Sweden. In Nat Cell Biol, Dec 2015
A dynamic transverse enrichment of atypical protein kinase C (aPKC) shifts the balance and transiently targets activated small GTPase RhoA, myosin phosphorylation and Rab11 vesicle trafficking to longitudinal junctions.
Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
New
Kim et al., South Korea. In J Neuroinflammation, Dec 2015
METHODS: We examined changes in mitogen-activated protein kinases (MAPKs), mitochondrial function [i.e., mitochondrial membrane potential, intramitochondrial Ca(2+) accumulation, mitochondrial oxidative burdens, mitochondrial superoxide dismutase expression, and mitochondrial translocation of the cleaved form of protein kinase C delta type (cleaved PKCδ)], microglial activity, and pro-apoptotic changes [i.e., cytosolic cytochrome c release, cleaved caspase 3, and terminal deoxynucleotidyl transferase dUDP nick-end labeling (TUNEL) positive populations] after a neurotoxic dose of MA in the striatum of mice to achieve a better understanding of the effects of apocynin, a non-specific PHOX inhibitor, or genetic inhibition of p47phox (by using p47phox knockout mice or p47phox antisense oligonucleotide) against MA-induced dopaminergic neurotoxicity.
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
New
Impact
McCormick et al., San Francisco, United States. In Cell, Dec 2015
Interrupting K-Ras-calmodulin binding using genetic means or by treatment with an orally active protein kinase C (PKC)-activator, prostratin, represses tumorigenesis in K-Ras mutant pancreatic cancer cells.
[Atp6ap2/ (Pro) renin Receptor is Required for Laminar Formation during Retinal Development in Mice].
Review
New
Kanda, In Nihon Ganka Gakkai Zasshi, Nov 2015
Among these molecules, co-immunoprecipitation using retinal homogenates and Atp6ap2/(P) RR-transfected cells showed that Atp6ap2/(P) RR interacted with partitioning defective 3 homolog (Par3) protein, known to play a pivotal role in planar cell polarity in the Par-atypical protein kinase C system.
Transcriptional regulation of hepatic lipogenesis.
Review
New
Impact
Sul et al., Berkeley, United States. In Nat Rev Mol Cell Biol, Nov 2015
After feeding, high blood glucose and insulin levels activate lipogenic genes through several pathways, including the DNA-dependent protein kinase (DNA-PK), atypical protein kinase C (aPKC) and AKT-mTOR pathways.
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.
New
Impact
Scherer et al., Dallas, United States. In Cell Metab, Sep 2015
Induction of ceramidase activity in either tissue promotes a lowering of hepatic ceramides and reduced activation of the ceramide-activated protein kinase C isoform PKCζ, though the induction of ceramidase activity in the adipocyte prompts more rapid resolution of hepatic steatosis than overexpression of the enzyme directly in the liver.
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
New
Impact
Baselga et al., New York City, United States. In Cancer Cell, May 2015
AXL dimerizes with and phosphorylates epidermal growth factor receptor (EGFR), resulting in activation of phospholipase Cγ (PLCγ)-protein kinase C (PKC), which, in turn, activates mTOR.
Mobile Phone Radiation: Physiological & Pathophysiologcal Considerations.
Review
New
K Sri, In Indian J Physiol Pharmacol, Apr 2015
Pathophysiological mechanisms of interaction of EMR at plasma membrane are calcium efflux from cell membranes, increased expression of stress proteins, influence on channels/gap junctions in cell membrane, overproduction of reactive oxygen species, ornithine decarboxylase activation, reduction in melatonin levels, decrease in protein kinase C activity, damage to DNA and change in gene expression in brain cells and altered blood-brain barrier.
The Receptor for Activated C Kinase in Plant Signaling: Tale of a Promiscuous Little Molecule.
Review
Villanueva et al., Ecatepec, Mexico. In Front Plant Sci, 2014
Although RACK1 proteins maintain conserved Protein Kinase C binding sites, the lack of a bona fide PKC adds complexity and enigma to the nature of the ligand partners with which RACK1 interacts in plants.
A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC).
GeneRIF
Gründer et al., Aachen, Germany. In J Biol Chem, 2010
rBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel.
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.
GeneRIF
Kumar et al., Oxford, United Kingdom. In J Biol Chem, 2002
regulation by N4WBP5A
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