Protein Kinase C-epsilon
Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.
Santa Barbara, United States. In Addict Biol, Feb 2016
As the molecular bases for cocaine-related vmPFC deregulation remain elusive, the present study assayed the consequences of extended access to intravenous cocaine (6 hours/day; 0.25 mg/infusion for 10 day) on the activational state of protein kinase C epsilon (PKCε), an enzyme highly implicated in drug-induced neuroplasticity.