gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Histidine triad nucleotide binding protein 1

protein kinase C inhibitor
Sponsored links
Top mentioned proteins: V1a, HAD, ACID, CAN, MAPK
Papers using protein kinase C inhibitor antibodies
Identification of new nerve growth factor-responsive immediate-early genes.
Supplier
Chu Charleen T., In PLoS ONE, 2008
... Bisindolylmaleimide I, a protein kinase C inhibitor, was purchase from Cayman chemical (Ann Arbor, MI, ...
Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cells
Supplier
Roman Gregg, In PLoS ONE, 2005
... Bisindolylmaleimide I (BIM), a protein kinase C inhibitor, was purchased from Cayman Chemical (Ann Arbor, MI, ...
Role of intracellular calcium in regulation of phospholipase A2 in fMet-Leu-Phe-challenged human polymorph neutrophils
Supplier
Anderson Ronald et al., In Journal of Inflammation (London, England), 1994
... The highly selective protein kinase C inhibitor, GF10903X, was purchased from Tocris Cookson Ltd, UK ...
Papers on protein kinase C inhibitor
Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate.
New
Lee et al., South Korea. In Metabolism, Feb 2016
As a probable mechanism, we found that sDPP-4 caused dose-dependent increases in the expression levels of toll-like receptor 4 (TLR4) and TLR2 in RAW264.7 cells, and that these alterations were inhibited by vildagliptin, M6P, or bisindolylmaleimide II, a protein kinase C inhibitor.
The angiotensin II receptor antagonist, losartan, enhances regulator of G protein signaling 2 mRNA expression in vascular smooth muscle cells of Wistar rats.
New
Uehara et al., Shijiazhuang, China. In Hypertens Res, Feb 2016
Treatment with a protein kinase C inhibitor partially decreased losartan-mediated RGS2 mRNA expression.
Mechanisms Involved in Thromboxane A2 -induced Vasoconstriction of Rat Intracavernous Small Penile Arteries.
New
Simonsen et al., Århus, Denmark. In Basic Clin Pharmacol Toxicol, Jan 2016
Y27632 induced less relaxation in mesenteric arteries, H1152P induced equipotent relaxations, and a protein kinase C inhibitor, Ro-318220, failed to relax intracavernous penile arteries, but induced full relaxation in rat mesenteric arteries.
The Protein Kinase C Inhibitor: Ruboxistaurin.
Review
New
Lang et al., In Dev Ophthalmol, Dec 2015
The isozyme protein kinase C (PKC) β is involved in several processes that are deregulated in different retinal cell types by hyperglycemia.
Fucoxanthin Induced Suicidal Death of Human Erythrocytes.
Lang et al., In Cell Physiol Biochem, 2014
The effect of fucoxanthin on annexin-V-binding was significantly blunted, but not abolished by removal of extracellular Ca2+, and was insensitive to p38 kinase inhibitor skepinone (2 µM) and to protein kinase C inhibitor calphostin (100 nM).
Triggering of Suicidal Erythrocyte Death by Zosuquidar.
Lang et al., In Cell Physiol Biochem, 2014
The up-regulation of annexin-V-binding following zosuquidar (4 µg/ml) treatment was significantly blunted by removal of extracellular Ca2+, by presence of p38 kinase inhibitor SB203580 (2 µM) and by presence of protein kinase C inhibitor calphostin (100 nM).
Effect of tyramine on the production of interstitial adenosine during perfusion with adenosine 5'-monophosphate in rat hearts in vivo.
Review
Miyashita et al., Yokkaichi, Japan. In Eur J Pharmacol, 2013
Tyramine (1mM) increased the adenosine concentration measured in the presence of 100 μM adenosine 5'-monophosphate, an increase which was inhibited by antagonist of the α(1)-adrenoceptors (prazosin, 50 μM) or of a protein kinase C inhibitor (chlerythrine, 10 μM), and in reserpinized rats, tyramine failed to increase the adenosine 5'-monophosphate-primed dialysate adenosine concentration.
Diabetic neuropathy and oxidative stress: therapeutic perspectives.
Review
Abdollahi et al., Tehrān, Iran. In Oxid Med Cell Longev, 2012
With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril).
Renal-sparing regimens employing new agents.
Review
Klintmalm et al., Fort Worth, United States. In Curr Opin Organ Transplant, 2012
In a phase 2 multicenter study, sotrastaurin, a protein kinase C inhibitor, has shown promise in preserving renal graft function but lacks potency as an immunosuppressive agent.
A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 Å resolution.
GeneRIF
Nawrot et al., Łódź, Poland. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the human HINT1-adenosine 5'-monophosphate (AMP) complex at 1.38 A resolution obtained from a new monoclinic crystal form is reported
Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.
GeneRIF
Guo et al., Jupiter, United States. In J Phys Chem B, 2012
The results reveal the structural basis for the remarkable adenylate surveillance activity of Hint1, to potentially control Ap(4)A levels in the cell.
The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells.
GeneRIF
Sgambato et al., New York City, United States. In Cell Cycle, 2012
The tumor suppressor activity of HINT1 gene in melanoma cells by promoting the formation of non-functional complexes with oncogenic transcription factors, like MITF and beta-catenin, known to be involved in melanoma development and progression.
Differential expression of HINT1 in schizophrenia brain tissue.
GeneRIF
Martins-de-Souza et al., München, Germany. In Eur Arch Psychiatry Clin Neurosci, 2012
This study demonistrated that HINT1 is found to be downregulated in the dorsolateral prefrontal cortex and upregulated in the thalamus.
Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins.
GeneRIF
Wagner et al., Minneapolis, United States. In Bioorg Med Chem Lett, 2012
evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins
Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling.
Review
Li et al., Mainz, Germany. In Br J Pharmacol, 2011
These include the protein kinase C inhibitor midostaurin, the pentacyclic triterpenoids ursolic acid and betulinic acid, the eNOS enhancing compounds AVE9488 and AVE3085, and the polyphenolic phytoalexin trans-resveratrol.
Chemoradiotherapy in malignant glioma: standard of care and future directions.
Review
Impact
Chakravarti et al., Lausanne, Switzerland. In J Clin Oncol, 2007
The addition of tyrosine kinase inhibitors vatalanib (PTK787) and vandetinib (ZD6474), the integrin inhibitor cilengitide, the monoclonal antibodies bevacizumab and cetuximab, the mammalian target of rapamycin inhibitors temsirolimus and everolimus, and the protein kinase C inhibitor enzastaurin, among other agents, are in clinical investigation, building on the established chemoradiotherapy regimen for newly diagnosed glioblastoma.
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
Impact
Schwartz et al., New York City, United States. In J Clin Oncol, 2005
PURPOSE: Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN-01) potentiates the cytotoxic effects of fluorouracil (FU).
Vimentin is secreted by activated macrophages.
Impact
Markovitz et al., Ann Arbor, United States. In Nat Cell Biol, 2003
We show that secretion of vimentin, which is phosphorylated at serine and threonine residues, is enhanced by the phosphatase inhibitor okadaic acid and blocked by the specific protein kinase C inhibitor GO6983.
Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.
Impact
Twelves et al., Glasgow, United Kingdom. In J Clin Oncol, 2001
PURPOSE: N-Benzoyl staurosporine (PKC412) is a protein kinase C inhibitor with antitumor activity in laboratory models.
Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons.
Impact
Satin et al., Richmond, United States. In Science, 1997
The Mg2+ blockade was partially restored by increased extracellular Mg2+ concentration or by pretreatment with the protein kinase C inhibitor calphostin C.
share on facebooktweetadd +1mail to friends