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Protein kinase, cAMP-dependent, catalytic, alpha

protein kinase A catalytic subunit, PKA Calpha, PRKACA
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, PRKACB
Papers on protein kinase A catalytic subunit
Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology.
Review
New
Scott et al., Seattle, United States. In Gene, Mar 2016
This article focuses on the discovery, structure, cellular location and physiological effects of the catalytic subunit alpha of protein kinase A (encoded by the gene PRKACA).
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Review
New
Assie et al., Paris, France. In Eur J Endocrinol, Feb 2016
Exome sequencing identified new major drivers in all tumor types, including KCNJ5, ATP1A1, ATP2B3 and CACNA1D mutations in aldosterone producing adenomas (APA), PRKACA mutations in cortisol producing adenomas (CPA), ARMC5 mutations in primary bilateral macronodular adrenocortical hyperplasia (PBMAH), and ZNRF3 mutations in adrenocortical carcinomas (ACC).
GNAS mutations in adrenal aldosterone-producing adenomas.
New
Yamada et al., Maebashi, Japan. In Endocr J, Feb 2016
Mutations have also recently been reported in adrenal cortisol-producing adenomas (CPAs), in addition to those in the PRKACA gene.
Genealogical correspondence of a forebrain centre implies an executive brain in the protostome-deuterostome bilaterian ancestor.
New
Strausfeld et al., Tucson, United States. In Philos Trans R Soc Lond B Biol Sci, Feb 2016
These proteins include cAMP-dependent protein kinase A catalytic subunit (PKA-Cα) and phosphorylated Ca(2+)/calmodulin-dependent protein kinase II (pCaMKII), both required for long-term memory formation which is enriched in rodent hippocampus and insect mushroom bodies, both implicated in allocentric memory and both possessing corresponding neuronal architectures.
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
New
Fassnacht et al., Milano, Italy. In Eur J Endocrinol, Jan 2016
Recently, mutations affecting the USP8 and PRKACA gene have been reported in ACTH-secreting pituitary adenomas and cortisol-secreting adrenocortical adenomas, respectively.
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
New
Simon et al., New York City, United States. In Proc Natl Acad Sci U S A, Dec 2015
Fibrolamellar hepatocellular carcinoma (FLHCC) tumors all carry a deletion of ∼400 kb in chromosome 19, resulting in a fusion of the genes for the heat shock protein, DNAJ (Hsp40) homolog, subfamily B, member 1, DNAJB1, and the catalytic subunit of protein kinase A, PRKACA.
cAMP signaling in cortisol-producing adrenal adenoma.
Review
New
Beuschlein et al., Würzburg, Germany. In Eur J Endocrinol, Oct 2015
During the last year, a report by our group and three additional independent groups showed that somatic mutations of PRKACA, the gene coding for the catalytic subunit α of PKA, are a common genetic alteration in patients with Cushing's syndrome due to adrenal adenomas, occurring in 35-65% of the patients.
Carney complex: an update.
Review
New
Stratakis et al., Bethesda, United States. In Eur J Endocrinol, Oct 2015
Most recently, components of the complex have been associated with defects of other PKA subunits, such as the catalytic subunits PRKACA (adrenal hyperplasia) and PRKACB (pigmented spots, myxomas, pituitary adenomas).
Genomic spectra of biliary tract cancer.
New
Impact
Shibata et al., Tokyo, Japan. In Nat Genet, Sep 2015
Gene fusions involving FGFR2 and PRKACA or PRKACB preferentially occurred in ICC and ECC, respectively, and the subtype-associated prevalence of actionable growth factor-mediated signals was noteworthy.
Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells.
Reid et al., Chapel Hill, United States. In Nat Commun, 2014
RNA-seq analysis confirms the presence of a fusion transcript (DNAJB1-PRKACA) characteristic of hFL-HCC tumours.
Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors.
Review
Ragazzon et al., Paris, France. In Front Endocrinol (lausanne), 2014
Among these are somatic mutations of PKA catalytic subunit alpha gene (PRKACA) in ACA, germline, and somatic mutations of armadillo repeat containing 5 gene (ARMC5) in primary bilateral macronodular adrenal hyperplasia and somatic alterations of the E3 ubiquitin ligase gene ZNRF3 in ACC.
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.
Impact
Lifton et al., New Haven, United States. In Nat Genet, 2014
Six others had somatic mutations in PRKACA (protein kinase A (PKA) catalytic subunit) resulting in a p.Leu206Arg substitution.
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
Impact
Ogawa et al., Kyoto, Japan. In Science, 2014
We report a hotspot mutation (L206R) in PRKACA, which encodes the catalytic subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), in more than 50% of cases with adrenocortical adenomas associated with corticotropin-independent Cushing's syndrome.
Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome.
Impact
Ning et al., Shanghai, China. In Science, 2014
We identified a hotspot in the PRKACA gene with a L205R mutation in 69.2% (27 out of 39) of ACAs and validated in 65.5% of a total of 87 ACAs.
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.
Impact
Simon et al., New York City, United States. In Science, 2014
The chimeric RNA is predicted to code for a protein containing the amino-terminal domain of DNAJB1, a homolog of the molecular chaperone DNAJ, fused in frame with PRKACA, the catalytic domain of protein kinase A. Immunoprecipitation and Western blot analyses confirmed that the chimeric protein is expressed in tumor tissue, and a cell culture assay indicated that it retains kinase activity.
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
GeneRIF
Zaccolo et al., Glasgow, United Kingdom. In J Cell Biol, 2012
PKA-phosphodiesterase(PDE)4D3-A kinase anchor protein (AKAP)9 complex generates spatial compartmentalization of cyclic adenosine monophosphate (cAMP) signaling at the centrosome.
Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression.
GeneRIF
Roussa et al., Freiburg, Germany. In Int J Biochem Cell Biol, 2012
Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression.
Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages.
GeneRIF
Chong et al., Seoul, South Korea. In Exp Neurol, 2012
The effect of norepinephrine on amyloid beta(1-42) peptide-induced responses in migroglia-like THP-1 cells is contingent on cyclic AMP/PKA pathways and cAMP responsive element binding protein (CREB) activation.
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
GeneRIF
Chini et al., Rochester, United States. In J Biol Chem, 2012
Data indicate that an increase in cAMP/PKA activity resulted in the dissociation of SIRT1 and DBC1 in an AMP-activated protein kinase (AMPK)-dependent manner.
Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells.
GeneRIF
Liu et al., Blacksburg, United States. In Endocrinology, 2012
genistein may play a beneficial role in vascular function through targeting the PKA/CREB/eNOS/NO signaling pathway
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