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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein C

Protein C
vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, CAN, APC, AGE, thrombomodulin
Papers on Protein C
Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels.
New
Bowers et al., Santa Barbara, United States. In J Am Chem Soc, Feb 2016
In addition, we find that larger oligomers of these fragments may adopt β-barrel structures and that β-barrels can be formed by folding an out-of-register β-sheet, a common type of structure found in amyloid proteins.
Plasma Thrombin Generation and Sensitivity to Activated Protein C Among Patients With Myeloma and Monoclonal Gammopathy of Undetermined Significance.
New
Ní Áinle et al., Cork, Ireland. In Clin Appl Thromb Hemost, Feb 2016
In the presence of APC, endogenous thrombin potential was significantly lower in control plasma (228.6 ± 44.5 nmol/L × min) than in either myeloma (866.2 ± 241.3 nmol/L × min, P = .01)
Clinically Linked Mutations in the Central Domains of Cardiac Myosin-Binding Protein C with Distinct Phenotypes Show Differential Structural Effects.
New
Trewhella et al., Sydney, Australia. In Structure, Feb 2016
Bioinformatics and modeling were used to initially predict the expected structural impacts and assess the broader implications for function based on sequence conservation patterns.
Tissue Factor Pathway Inhibitor, Activated Protein C Resistance, and Risk of Coronary Heart Disease Due To Combined Estrogen Plus Progestin Therapy.
New
Rossouw et al., Seattle, United States. In Arterioscler Thromb Vasc Biol, Jan 2016
Baseline tissue factor pathway activity and APC resistance singly or jointly did not significantly modify the effect of estrogen plus progestin on CHD risk.
Protein C deficiency related obscure gastrointestinal bleeding treated by enteroscopy and anticoagulant therapy.
Review
New
Chung et al., Taipei, Taiwan. In World J Gastroenterol, Feb 2015
Computed tomography of the abdomen revealed multiple vascular tufts around the proximal jejunum but no evidence of cirrhosis, and a visible hypodense filling defect suggestive of thrombus was visible in the superior mesenteric vein.
Novel Functions of the Anticoagulant Activated Protein C in Maintaining Skin Barrier Integrity to Impact on Skin Disease.
Review
Jackson et al., Sydney, Australia. In Pathobiology, 2014
Activated protein C (APC) or its precursor, protein C, is abundantly expressed by skin epidermal keratinocytes and stimulates their proliferation and migration, and inhibits apoptosis and inflammation, leading to a healing phenotype.
Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Lee et al., South Korea. In Molecules, 2014
This SN-induced inhibition of adipogenic factors was shown to be due to the regulatory effect of SN on early adipogenic factors; SN downregulated the expression of Krueppel-like factor 4 (KLF4), KLF5, CCAAT-enhancer-binding protein β (C/EBPβ), C/EBPδ, and Protein C-ets-2 (ETS2), while KLF2, an anti-early adipogenic factor, was upregulated by SN.
Plasma biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis*.
Review
Groeneveld et al., Amsterdam, Netherlands. In Crit Care Med, 2014
Clinical outcomes included 1) diagnosis of acute respiratory distress syndrome in the at-risk population and 2) mortality in acute respiratory distress syndrome patients.
Traumatic coagulopathy--part 1: Pathophysiology and diagnosis.
Review
Martin et al., Auburn, United States. In J Vet Emerg Crit Care (san Antonio), 2014
Excessive activation of the thrombin-thrombomodulin activated Protein C pathway, catecholamine-induced endothelial damage as well as disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype are all hypotheses that have been proposed in attempts to explain the functional mechanism of ATC.
Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.
Review
Marston et al., London, United Kingdom. In Front Physiol, 2013
β-adrenergic stimulation of heart muscle cells leads to release of cyclic-AMP and the activation of protein kinase A which phosphorylates key proteins in the sarcolemma, sarcoplasmic reticulum and contractile apparatus.
Effect of protein C gene mutation on coagulation and inflammation in hemorrhagic shock.
GeneRIF
Cryer et al., Los Angeles, United States. In J Surg Res, 2012
mutated Protein C did not appear to alter the levels of NFkB or fibrinogen in our model of hemorrhagic shock and resuscitation.
Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
GeneRIF
Jackson et al., Sydney, Australia. In J Biol Chem, 2012
The aPC mechanism of action is complex, involving induction of Treg differentiation, inhibition of inflammation, and possibly direct cyto-protective effects on beta cells.
Activated protein C improves pial microcirculation in experimental endotoxemia in rats.
GeneRIF
Lehmann et al., Halifax, Canada. In Microvasc Res, 2012
APC treatment significantly improves pial microcirculation by reducing leukocyte adhesion and increasing functional capillary density
sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove.
GeneRIF
Hermida et al., Pamplona, Spain. In Blood, 2012
We conclude that activated protein C generation and function can be modulated by changes in phospholipid occupancy of its endothelial cell receptor.
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation.
GeneRIF
Danese et al., Milano, Italy. In Proc Natl Acad Sci U S A, 2012
Findings show that the protein C (PC) pathway is a unique system involved in controlling intestinal homeostasis and inflammation by regulating epithelial barrier function.
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.
Impact
Hogan et al., Durham, United States. In Cell Stem Cell, 2009
In the postnatal mouse lung, it has been proposed that bronchioalveolar stem cells (BASCs) which coexpress Scgb1a1 (Secretoglobin1a1) and SftpC (Surfactant Protein C), contribute descendants to both bronchioles and alveoli.
An economic evaluation of activated protein C treatment for severe sepsis.
Impact
Donaldson et al., Calgary, Canada. In N Engl J Med, 2002
A post hoc reanalysis by the Food and Drug Administration (FDA) of data from this study suggested that the reduction in mortality was restricted to patients with Acute Physiology and Chronic Health Evaluation (APACHE II) scores of 25 or more.
Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans.
Impact
Casey et al., Dublin, Ireland. In Lancet, 1997
After a test dose of protein-C concentrate, patients received a continuous infusion with the dose adjusted daily to keep the plasma concentration between 0.8 and 1.2 IU/mL.
Multiple organ dysfunction syndrome in bone marrow transplantation.
Impact
Kessinger et al., Omaha, United States. In Jama, 1995
OBJECTIVE: To define the frequency and outcome of organ dysfunction in bone marrow transplantation (BMT) and to determine if patients with organ dysfunction have lower levels of protein C (PC) and/or antithrombin III (ATIII) than those without organ dysfunction.
Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect.
Impact
Briët et al., Leiden, Netherlands. In Lancet, 1993
We found a significant difference in the thrombosis-free survival of the 77 heterozygotes and 84 normals: by age 45, 50% of heterozygotes and 10% of normal relatives can be expected to have had a manifestation of venous thromboembolism.
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