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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Protein A
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, STEP, ACID, HAD, fibrillin-1
Papers on Protein A
Inhibitory effects of Antibiofilm compound 1 in Staphylococcus aureus biofilms.
Sugai et al., Hiroshima, Japan. In Microbiol Immunol, Feb 2016
We demonstrated ABC-1 inhibits biofilm formation in these strains at micromolar concentrations regardless of the strains' dependence on Polysaccharide Intercellular Adhesin (PIA), cell wall-associated protein dependent or cell wall- associated extracellular DNA (eDNA).
Multimodal charge-induction chromatography for antibody purification.
Yao et al., Hangzhou, China. In J Chromatogr A, Feb 2016
High affinity to IgG was found with the saturated adsorption capacity of 70.4mg/ml at pH 7, and the flow rate of mobile phase showed little impact on the dynamic binding capacity.
Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein AP2.
Stamme et al., Germany. In Am J Respir Cell Mol Biol, Feb 2016
Kinetic studies employing confocal microscopy, Western analysis, and immunomagnetic sorting revealed that SP-A transiently enhances the basal protein expression of CHC and α-adaptin depending on early activation of protein kinase CK2 and Akt1 in primary AMs from rats, SP-A+/+, and SP-A-/- mice as well as in vivo when intratracheally administered to SP-A+/+ mice.
Outer Membrane Protein A Plays a Role in Pathogenesis of Acinetobacter nosocomialis.
Lee et al., Taegu, South Korea. In Virulence, Feb 2016
Cytotoxicity was not significantly different between the wild-type strain and the ΔompA mutant when A549 cells were infected with bacteria or treated with outer membrane vesicles (OMVs).
Advance chromatin extraction improves capture performance of protein A affinity chromatography.
Gagnon et al., Singapore, Singapore. In J Chromatogr A, Jan 2016
Two protein A media with IgG capacities in excess of 50g/L were loaded with chromatin-extracted harvest, washed with 2.0M NaCl before elution, and the eluted IgG fraction titrated to pH 5.5 before microfiltration.
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response.
Zou et al., United States. In Cell Res, 2015
The RPA-ssDNA platform also constitutes a key physiological signal which activates the master ATR kinase to protect and repair stalled or collapsed replication forks during replication stress.
Artificial affinity proteins as ligands of immunoglobulins.
Pecorari et al., Nantes, France. In Biomolecules, 2014
Some of them are widely used as reagents for detection or capture applications, such as Protein G and Protein A. However, these natural proteins have a defined spectrum of recognition that may not fit specific needs.
A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.
Lerner et al., Los Angeles, United States. In Science, 2014
Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the κ and λ light chains.
BRCA2: one small step for DNA repair, one giant protein purified.
Jensen, New Haven, United States. In Yale J Biol Med, 2013
Many of the biochemical features that allow BRCA2 to choreograph the activities of RAD51 have been elucidated and include: targeting RAD51 to single-stranded DNA while inhibiting binding to dsDNA, reducing the ATPase activity of RAD51, and facilitating the displacement of the single-strand DNA binding protein, Replication Protein A. These reinforcing activities of BRCA2 culminate in the correct positioning of RAD51 onto a processed DNA double-strand break and initiate its faithful repair by homologous recombination.
Ligands and receptors of lung surfactant proteins SP-A and SP-D.
Sim et al., Oxford, United Kingdom. In Front Biosci, 2012
The aim of this review is to provide an overview of the current knowledge of ligands and receptors that are known to interact with SP-A and SP-D.
The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells.
Ma et al., Shanghai, China. In Biochem J, 2012
PSAP is a novel TFPI-2-interacting protein and that the binding sites are the KD2 of TFPI-2 and the C-terminus of PSAP.
Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL.
Carrodeguas et al., Zaragoza, Spain. In Febs Lett, 2011
Data suggest that the transmembrane domain of Bcl-XL could be involved in protein oligomerization, shown here with presenilin-1 associated protein.
Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery.
Pandey et al., Bengaluru, India. In Cancer Biol Ther, 2011
novel esophageal squamous cell carcinoma marker PSAP was identified by mass spectrometry and immunohistochemical analysis
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
PSAP is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
A play in four acts: Staphylococcus aureus abscess formation.
Missiakas et al., Chicago, United States. In Trends Microbiol, 2011
In support of this model, only live S. aureus is able to form abscesses, requiring genes that act at one or more of four discrete stages during the development of these infectious lesions.
Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells.
Yuan et al., Jinan, China. In J Cell Biochem, 2011
saposin C caused stimulation of androgen receptor expression and activity by associations with Src kinases
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.
Rudolph et al., Hannover, Germany. In Cell, 2007
Exo1 deletion impaired upstream induction of DNA damage responses by reducing ssDNA formation and the recruitment of Replication Protein A (RPA) and ATR at DNA breaks.
A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium.
Malawista et al., New Brunswick, United States. In N Engl J Med, 1998
METHODS: For this double-blind trial, 10,305 subjects 18 years of age or older were recruited at 14 sites in areas of the United States where Lyme disease was endemic; the subjects were randomly assigned to receive either placebo (5149 subjects) or 30 microg of OspA vaccine (5156 subjects).
Design, synthesis, and application of a protein A mimetic.
Lowe et al., Cambridge, United Kingdom. In Nat Biotechnol, 1998
One of the ligands binds IgG competitively with SpA in solution and when immobilized on agarose beads, with an affinity constant of 10(5)-10(6) M-1.
Light activatable antibodies: models for remotely activatable proteins.
Thompson et al., Newcastle upon Tyne, United Kingdom. In Nat Med, 1996
This is based on our demonstration that relatively large amounts of the a-methyl substituted 2-nitrobenzyl alcohol, namely, 1-(2-nitrophenyl)ethanol (NPE) can be coupled to proteins using diphosgene.
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