Inhibitory effects of Antibiofilm compound 1 in Staphylococcus aureus biofilms.
Hiroshima, Japan. In Microbiol Immunol, Feb 2016
We demonstrated ABC-1 inhibits biofilm formation in these strains at micromolar concentrations regardless of the strains' dependence on Polysaccharide Intercellular Adhesin (PIA), cell wall-associated protein dependent or cell wall- associated extracellular DNA (eDNA).
Artificial affinity proteins as ligands of immunoglobulins.
Nantes, France. In Biomolecules, 2014
Some of them are widely used as reagents for detection or capture applications, such as Protein G and Protein A. However, these natural proteins have a defined spectrum of recognition that may not fit specific needs.
BRCA2: one small step for DNA repair, one giant protein purified.
New Haven, United States. In Yale J Biol Med, 2013
Many of the biochemical features that allow BRCA2 to choreograph the activities of RAD51 have been elucidated and include: targeting RAD51 to single-stranded DNA while inhibiting binding to dsDNA, reducing the ATPase activity of RAD51, and facilitating the displacement of the single-strand DNA binding protein, Replication Protein A. These reinforcing activities of BRCA2 culminate in the correct positioning of RAD51 onto a processed DNA double-strand break and initiate its faithful repair by homologous recombination.